Volume 5 of Contemporary Nephrology summarizes major advances in 15 different areas of nephrology. As in previous volumes the different chapters constitute up of the discipline contributed by individuals dates in both basic and clinical aspects with in-depth expertise in their respective areas. We are grateful to the authors for their outstanding contributions to this fifth volume. Drs. Reuss and Cotton review in Chapter 1 new advances in our understanding of water transport in epithelial tissues responsive to antidiuretic hormone. In Chap ters 2 and 3 Dr. Knox and Dr. Schoolwerth and their…mehr
Volume 5 of Contemporary Nephrology summarizes major advances in 15 different areas of nephrology. As in previous volumes the different chapters constitute up of the discipline contributed by individuals dates in both basic and clinical aspects with in-depth expertise in their respective areas. We are grateful to the authors for their outstanding contributions to this fifth volume. Drs. Reuss and Cotton review in Chapter 1 new advances in our understanding of water transport in epithelial tissues responsive to antidiuretic hormone. In Chap ters 2 and 3 Dr. Knox and Dr. Schoolwerth and their associates summarize respec tively new information in the areas of renal hemodynamics and electrolyte excre tion, and renal metabolism. Chapter 4, written by Drs. Laski and Kurtzman, updates recent developments in the regulation of acid-base balance in health and disease. Chapter 5, contributed by Drs. Sutton and Cameron, provides the reader with a detailed account of progress in the area of mineral metabolism. In Chapter 6, Dr. Campese examines the contribution of sodium, calcium, and neurogenic factors in the pathogenesis of essential hypertension. The immunological aspects of renal disease are clearly discussed by Dr. Couser in Chapter 7. New developments in this field are emphasized and should provide the reader with a clear understanding of the direction in which this field is moving. Drs. Humes and Messana (Chapter 8) discuss selected areas in which new developments have occurred in our understand ing of acute renal failure and toxic nephropathy.
1:Water Transport across ADH-Sensitive Epithelia.- 1. Introduction.- 2. A Working Hypothesis.- 3. Biochemical Aspects of the Mechanism of Action of ADH.- 4. Biophysics of Osmotic Water Flow.- 5. Experimental Bases for the Pore Hypothesis of Water Permeation.- 6. Role of the Cytoskeleton and Modulation of the Hydrosmotic Effect of ADH.- 7. Other Barriers to Osmotic Water Flow.- 8. Remaining Questions and Future Directions.- References.- 2:Renal Hemodynamics and Sodium Chloride Excretion.- 1. Renal Hemodynamics.- 2. Sodium Chloride Excretion and Regulation.- 3. Function of Discrete Nephron Segments.- 3:Renal Metabolism.- 1. Introduction.- 2. Renal Substrate Utilization.- 3. Effects of Acidosis on Renal Gene Expression.- 4. Adenosine in the Kidney.- 4:Acid-Base Physiology and Pathophysiology.- 1. Introduction.- 2. The Proximal Tubule.- 3. Bicarbonate Reabsorption in the Proximal Tubule.- 4. LoopofHenle.- 5. The Distal Nephron.- 6. Respiratory Acidosis.- 7. Effects of Acidosis.- 8. Ammonia and Urea.- 9. Lactic Acidosis.- 10. Miscellaneous or Global Studies of Acidification.- 11. Clinical Acid-Base Physiology.- 5:Mineral Metabolism.- 1. Inorganic Phosphate.- 2. Calcium.- 3. Vitamin D.- 4. Magnesium.- References.- 6:Sodium, Calcium, and Neurogenic Factors in the Pathogenesis of Essential Hypertension.- 1. Introduction.- 2. Salt and Hypertension.- 3. Calcium and Hypertension.- 4. Relation between Abnormalities of Sodium and Calcium Metabolism in Hypertension.- References.- 7:Immunologic Aspects of Renal Disease.- 1. Introduction.- 2. Mechanisms of Immune Glomerular Injury.- 3. Clinical Aspects of Immune Renal Disease.- 4. Diseases That Commonly Present as Nephrotic Syndrome.- 5. Glomerular Involvement in Systemic Diseases.- 8:Acute Renal Failure and Toxic Nephropathy.- 1. General Aspects.- 2. Cyclosporine.- 3. Aminoglycosides.- 4. Radiocontrast Agent Nephrotoxicity.- 5. Ischemic Acute Renal Failure.- 6. Role of Reactive Oxygen Species in Postischemic Renal Injury.- References.- 9:The Kidney in Systemic Disease.- 1. Introduction.- 2. Disorders of the Renal Microvasculature.- 3. Renal Consequences of Tumors.- References.- 10:Congenital Disorders of the Kidneys and Tumors: Alport's Syndrome and Electrolyte and Metabolism Disorders in Apudomas.- 1. Alport's Syndrome.- 2. Electrolyte and Metabolic Disorders in Apudomas.- 11:The Uremic Syndrome.- 1. Introduction.- 2. Uremic Toxins.- 3. Progression of Renal Dysfunction.- 4. The Skin.- 5. The Muscles and Joints.- 6. The Gastrointestinal System.- 7. Pulmonary System.- 8. The Cardiovascular System.- 9. The Hematopoietic System.- 10. The Immune System.- 11. The Nervous System.- 12. The Endocrine System.- 12:Nutrition in Renal Disease.- 1. Introduction.- 2. Progression of Renal Disease.- 3. Metabolism in Chronic Renal Failure.- 4. Nutritional Management of CRF Patients.- 5. Nephrotic Syndrome.- 6. Vitamins and Trace Elements.- 7. Nutrition and Renal Transplantation.- 8. Acute Renal Failure.- References.- 13:Dialysis.- 1. Erythropoietin.- 2. New Middle Molecules.- 3. Biocompatibility of Synthetic Membranes.- 4. Peritoneal Dialysis.- 5. Hemodynamic Response to Dialysis.- 6. Shortening Treatment Time.- 7. Filtration Modalities.- 8. Access.- References.- 14:Renal Transplantation.- 1. Introduction.- 2. Immunosuppression.- 3. Cellular Basis of Allograft Rejection.- 4. Tomorrow's Shangri-la?.- References.- 15:Drugs and the Kidney.- 1. Introduction.- 2. Pharmacologic Principles and the Effects of Renal Disease.- 3. Drug Effects on Renal Function.- 4. Prescribing for Patients with Renal Dysfunction.- 5.Removal of Drugs by Extracorporeal Means and Peritoneal Dialysis.- 6. Aspects of Specific Drugs in Patients with Renal Disease.- 7. Drug Nephrotoxicity.
1:Water Transport across ADH-Sensitive Epithelia.- 1. Introduction.- 2. A Working Hypothesis.- 3. Biochemical Aspects of the Mechanism of Action of ADH.- 4. Biophysics of Osmotic Water Flow.- 5. Experimental Bases for the Pore Hypothesis of Water Permeation.- 6. Role of the Cytoskeleton and Modulation of the Hydrosmotic Effect of ADH.- 7. Other Barriers to Osmotic Water Flow.- 8. Remaining Questions and Future Directions.- References.- 2:Renal Hemodynamics and Sodium Chloride Excretion.- 1. Renal Hemodynamics.- 2. Sodium Chloride Excretion and Regulation.- 3. Function of Discrete Nephron Segments.- 3:Renal Metabolism.- 1. Introduction.- 2. Renal Substrate Utilization.- 3. Effects of Acidosis on Renal Gene Expression.- 4. Adenosine in the Kidney.- 4:Acid-Base Physiology and Pathophysiology.- 1. Introduction.- 2. The Proximal Tubule.- 3. Bicarbonate Reabsorption in the Proximal Tubule.- 4. LoopofHenle.- 5. The Distal Nephron.- 6. Respiratory Acidosis.- 7. Effects of Acidosis.- 8. Ammonia and Urea.- 9. Lactic Acidosis.- 10. Miscellaneous or Global Studies of Acidification.- 11. Clinical Acid-Base Physiology.- 5:Mineral Metabolism.- 1. Inorganic Phosphate.- 2. Calcium.- 3. Vitamin D.- 4. Magnesium.- References.- 6:Sodium, Calcium, and Neurogenic Factors in the Pathogenesis of Essential Hypertension.- 1. Introduction.- 2. Salt and Hypertension.- 3. Calcium and Hypertension.- 4. Relation between Abnormalities of Sodium and Calcium Metabolism in Hypertension.- References.- 7:Immunologic Aspects of Renal Disease.- 1. Introduction.- 2. Mechanisms of Immune Glomerular Injury.- 3. Clinical Aspects of Immune Renal Disease.- 4. Diseases That Commonly Present as Nephrotic Syndrome.- 5. Glomerular Involvement in Systemic Diseases.- 8:Acute Renal Failure and Toxic Nephropathy.- 1. General Aspects.- 2. Cyclosporine.- 3. Aminoglycosides.- 4. Radiocontrast Agent Nephrotoxicity.- 5. Ischemic Acute Renal Failure.- 6. Role of Reactive Oxygen Species in Postischemic Renal Injury.- References.- 9:The Kidney in Systemic Disease.- 1. Introduction.- 2. Disorders of the Renal Microvasculature.- 3. Renal Consequences of Tumors.- References.- 10:Congenital Disorders of the Kidneys and Tumors: Alport's Syndrome and Electrolyte and Metabolism Disorders in Apudomas.- 1. Alport's Syndrome.- 2. Electrolyte and Metabolic Disorders in Apudomas.- 11:The Uremic Syndrome.- 1. Introduction.- 2. Uremic Toxins.- 3. Progression of Renal Dysfunction.- 4. The Skin.- 5. The Muscles and Joints.- 6. The Gastrointestinal System.- 7. Pulmonary System.- 8. The Cardiovascular System.- 9. The Hematopoietic System.- 10. The Immune System.- 11. The Nervous System.- 12. The Endocrine System.- 12:Nutrition in Renal Disease.- 1. Introduction.- 2. Progression of Renal Disease.- 3. Metabolism in Chronic Renal Failure.- 4. Nutritional Management of CRF Patients.- 5. Nephrotic Syndrome.- 6. Vitamins and Trace Elements.- 7. Nutrition and Renal Transplantation.- 8. Acute Renal Failure.- References.- 13:Dialysis.- 1. Erythropoietin.- 2. New Middle Molecules.- 3. Biocompatibility of Synthetic Membranes.- 4. Peritoneal Dialysis.- 5. Hemodynamic Response to Dialysis.- 6. Shortening Treatment Time.- 7. Filtration Modalities.- 8. Access.- References.- 14:Renal Transplantation.- 1. Introduction.- 2. Immunosuppression.- 3. Cellular Basis of Allograft Rejection.- 4. Tomorrow's Shangri-la?.- References.- 15:Drugs and the Kidney.- 1. Introduction.- 2. Pharmacologic Principles and the Effects of Renal Disease.- 3. Drug Effects on Renal Function.- 4. Prescribing for Patients with Renal Dysfunction.- 5.Removal of Drugs by Extracorporeal Means and Peritoneal Dialysis.- 6. Aspects of Specific Drugs in Patients with Renal Disease.- 7. Drug Nephrotoxicity.
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