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Drawn from the authors' decade-long work in the cancer computational systems biology laboratory at Institut Curie, this self-contained guide explains how to apply computational systems biology approaches to cancer research. Suitable for readers in both computational and life sciences, the book provides proven techniques and tools for cancer bioinformatics and systems biology research. It explores how computational systems biology can help fight cancer in three essential aspects: categorizing tumors, finding new targets, and designing improved and tailored therapeutic strategies.