Compartmentalization, Adaptive Evolution and Therapeutic Response of HIV-1 in the Gastrointestinal Tract of African Patients Infected with Subtype C
Phetole Walter Mahasha
Broschiertes Buch

Compartmentalization, Adaptive Evolution and Therapeutic Response of HIV-1 in the Gastrointestinal Tract of African Patients Infected with Subtype C

Implications for the enhancement of therapeutic efficacy

Versandkostenfrei!
Versandfertig in 6-10 Tagen
47,99 €
inkl. MwSt.
PAYBACK Punkte
24 °P sammeln!
Due to its continuous exposure to food antigens and microbes, the gastrointestinal tract (GIT) is in a constant state of low level immune activation and contains an abundance of activated CCR5+CD4+ T lymphocytes, the primary target HIV-1. As a result, the GIT is a site of intense viral replication and severe CD4+ T cell depletion, a process that begins during primary HIV-1 infection and continues at a reduced rate during chronic infection in association with increased production of pro-inflammatory cytokines, a breakdown in the epithelial barrier, microbial translocation, systemic immune activ...