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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Common Toxicity Criteria (CTC), also referred to as the Common Terminology Criteria for Adverse Events (CTCAE), is a standardised classification of side effects used in assessing drugs for cancer therapy. It is a product of the National Cancer Institute. Currently version 4.0 is in use, released in 2009. Most US and UK drug trials base their observations on this system which has a range of grades from 1-5. Specific conditions and symptoms may have values or descriptive comment for each level, but the general guideline is: Mild, Moderate, Severe, Life threatening, Death.