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Trypanosomiasis is classified by the World Health Organization as one of the neglected parasitological diseases. Although efforts to eradicate it have borne fruit in many places, it remains prevalent and dangerous in certain parts of the world, where its transmission is conducive. Healthcare workers and learners therefore need to be very conversant with the clinical presentation and ultimately the diagnosis of trypanosomiasis. Comparisons of the clinical presentation, aetiology and management of African trypanosomiasis and the American type are quite interesting to learners and health care trainers. Should a patient with trypanosomiasis be encountered, healthcare teachers deployed to work in busy healthcare institutions and learners under their instruction require quick reference material to guide in diagnosis and management of trypanosomiasis. This book attempts to avail the summarized essential details to enable the readers save on time while searching for relevant information required for pathophysiology, clinical presentation, complications, diagnosis and management of trypanosomiasis.