This monograph contains the Proceedings of the Second International Symposium on the Pathophysiology of Cerebral Energy Metabolism, organized and sponsored by the Serbian Academy of Sciences and Art, in Belgrade, September 16-20, 1979. The purpose of the SYmposium was to promote an inter disciplinary discussion on Circu1atory and Deve1oprnenta1 Aspects of Brain Metabolism. Doctors G. Buznikov (Moscow), I. Klatzo (Bethesda), B. B. Mrsulja (Belgrade) . O. Z. Se1inger (Ann Arbor), and M. Spatz (Bethesda) served as members of the Advisory Board, chaired by Dr. Lj. H. Raki6 (Belgrade) , and he1ped…mehr
This monograph contains the Proceedings of the Second International Symposium on the Pathophysiology of Cerebral Energy Metabolism, organized and sponsored by the Serbian Academy of Sciences and Art, in Belgrade, September 16-20, 1979. The purpose of the SYmposium was to promote an inter disciplinary discussion on Circu1atory and Deve1oprnenta1 Aspects of Brain Metabolism. Doctors G. Buznikov (Moscow), I. Klatzo (Bethesda), B. B. Mrsulja (Belgrade) . O. Z. Se1inger (Ann Arbor), and M. Spatz (Bethesda) served as members of the Advisory Board, chaired by Dr. Lj. H. Raki6 (Belgrade) , and he1ped to plan the scientific pro gram. v CONTENTS 1 Opening Address S. Kanazir SECTION I CIRCULATORY ASPECTS Ischemia Related Changes in Adenine Nucleotide Metabolism . . . . . . . . 5 N. Murakami, W. D. Lust, F. A. M. de Azeredo and J. V. Passonneau Regional Glucose Metabolism and Nerve Cell Damage after Cerebral Ischemia in Normo- and Hypoglycemic Rats . . . . 23 N. H. Diemer and E. Siemkowicz Nuclear Cell Regulatory l1echanism in Cerebral Ischemia and Anoxia . . . . 33 T. Yanagihara Correlation of Amino Acid Concentrations, Permeability and Structural Changes in Monkey Brain Following Both Sustained and Transient Middle Cerebral Artery Occlusion . . 47 K. A. Conger and J . H. Garcia Histochemical and Biochemical Investigations on ATPase Activity Following Transient Brain Ischemia in Gerbils . . . .
Opening Address.- Section I Circulatory Aspects.- Ischemia Related Changes in Adenine Nucleotide Metabolism.- Regional Glucose Metabolism and Nerve Cell Damage after Cerebral Ischemia in Normo- and Hypoglycemic Rats.- Nuclear Cell Regulatory Mechanism in Cerebral Ischemia and Anoxia.- Correlation of Amino Acid Concentrations, Permeability and Structural Changes in Monkey Brain Following Both Sustained and Transient Middle Cerebral Artery Occlusion.- Histochemical and Biochemical Investigations on ATPase Activity Following Transient Brain Ischemia in Gerbils.- The Ischemic and Postischemic Effect on the Activities of Cerebral Monoamine Oxidase, Cytochrome Oxidase and Acetylcholinesterase in Mongolian Gerbils.- Oscillatory Pattern of Catecholamine Metabolism Following Transient Cerebral Ischemia in Gerbils.- Influence of Barbiturates, Hypothermia and Hemodilution on Post-Ischemic Metabolism and Functional Recovery Following Cerebro-Circulatory Arrest in Cats.- Behavior of the Habenulo-Pineal Complex in Deep Hypothermia (Cold, Hypoxia, Hypercapnia).- Mechanisms of Ischemic Brain Damage in Acute Arterial Hypertension.- The Effect of Chemically and Electrically Induced Acute Hypertension on the Permeability Across Cerebral Vessels.- The Pathology of Intracerebral Arteriolar Spasm.- Intravascular Aggregation of Platelets and Cerebrovascular Insufficiency.- Further Studies on Isolated Brain Capillaries: Some Characteristics of the Adenosine Triphosphatase, Adenylate- and Guanylate Cyclase.- Metabolic Patterns in Cerebral Capillaries.- Studies on the Blood-Brain Barrier (BBB) to Monoamines.- Dynamics of Postischemia: Enzymes in Brain Capillaries.- Section II Developmental Aspects.- Ontogeny of Membrane-Bound Protein Phosphorylating Systems in the Rat.- Tubulin in Developing RatBrain: Regional Distribution and Effect of Glucocorticoids.- Transfer Ribonucleic Acids in the Developing Brain: The Effect of the Convulsant Methionine Sulfoximine on tRNA Function.- General and Regional Turnover of Ribosomal Ribonucleic Acids in the Brain of Male and Female Rats During Postnatal Development.- Changes of the Soluble and Insoluble Glycoprotein Glycans During Rat Brain Development.- Acid Mucopolysaccharides and Myelin Development.- Neuronal-Glial Interactions During Neural Growth in Culture.- Effects of Convulsions on Rabbit Hippocampal Gangliosides During Hippocampus Development.- Brain Development and Learning.- Early Sea Urchin Embryo as a Model for the Study of Pre-Nervous Functions of Neurotransmitters. New Data.- Effect of Unilateral Deafferentation on the Development of the Lateral Geniculate Nucleus of the Dog.- Anatomo-Histological Studies of Caudate Nucleus - Visual System Relations.- Development of the Medullo-Spinal Cerebrospinal Fluid-Contacting Neurons.- Phylogenetic Aspects of the Sensory Neurons of the Wall of the Diencephalon.- Participants.
Opening Address.- Section I Circulatory Aspects.- Ischemia Related Changes in Adenine Nucleotide Metabolism.- Regional Glucose Metabolism and Nerve Cell Damage after Cerebral Ischemia in Normo- and Hypoglycemic Rats.- Nuclear Cell Regulatory Mechanism in Cerebral Ischemia and Anoxia.- Correlation of Amino Acid Concentrations, Permeability and Structural Changes in Monkey Brain Following Both Sustained and Transient Middle Cerebral Artery Occlusion.- Histochemical and Biochemical Investigations on ATPase Activity Following Transient Brain Ischemia in Gerbils.- The Ischemic and Postischemic Effect on the Activities of Cerebral Monoamine Oxidase, Cytochrome Oxidase and Acetylcholinesterase in Mongolian Gerbils.- Oscillatory Pattern of Catecholamine Metabolism Following Transient Cerebral Ischemia in Gerbils.- Influence of Barbiturates, Hypothermia and Hemodilution on Post-Ischemic Metabolism and Functional Recovery Following Cerebro-Circulatory Arrest in Cats.- Behavior of the Habenulo-Pineal Complex in Deep Hypothermia (Cold, Hypoxia, Hypercapnia).- Mechanisms of Ischemic Brain Damage in Acute Arterial Hypertension.- The Effect of Chemically and Electrically Induced Acute Hypertension on the Permeability Across Cerebral Vessels.- The Pathology of Intracerebral Arteriolar Spasm.- Intravascular Aggregation of Platelets and Cerebrovascular Insufficiency.- Further Studies on Isolated Brain Capillaries: Some Characteristics of the Adenosine Triphosphatase, Adenylate- and Guanylate Cyclase.- Metabolic Patterns in Cerebral Capillaries.- Studies on the Blood-Brain Barrier (BBB) to Monoamines.- Dynamics of Postischemia: Enzymes in Brain Capillaries.- Section II Developmental Aspects.- Ontogeny of Membrane-Bound Protein Phosphorylating Systems in the Rat.- Tubulin in Developing RatBrain: Regional Distribution and Effect of Glucocorticoids.- Transfer Ribonucleic Acids in the Developing Brain: The Effect of the Convulsant Methionine Sulfoximine on tRNA Function.- General and Regional Turnover of Ribosomal Ribonucleic Acids in the Brain of Male and Female Rats During Postnatal Development.- Changes of the Soluble and Insoluble Glycoprotein Glycans During Rat Brain Development.- Acid Mucopolysaccharides and Myelin Development.- Neuronal-Glial Interactions During Neural Growth in Culture.- Effects of Convulsions on Rabbit Hippocampal Gangliosides During Hippocampus Development.- Brain Development and Learning.- Early Sea Urchin Embryo as a Model for the Study of Pre-Nervous Functions of Neurotransmitters. New Data.- Effect of Unilateral Deafferentation on the Development of the Lateral Geniculate Nucleus of the Dog.- Anatomo-Histological Studies of Caudate Nucleus - Visual System Relations.- Development of the Medullo-Spinal Cerebrospinal Fluid-Contacting Neurons.- Phylogenetic Aspects of the Sensory Neurons of the Wall of the Diencephalon.- Participants.
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