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This issue of Veterinary Clinics of North America: Small Animal Practice focuses on Chronic Kidney Disease. Article topics include: New Biomarkers for Detecting Kidney Disease; Is Progressive CKD a Slow AKI?; Current Understanding of the Pathogenesis of Progressive CKD in Cats; Controversies; Update on Managing Feeding and Hydration in Dogs and Cats with CKD; Update on Phosphorous and Calcitriol Therapy; Update on Medical Management of Clinical Manifestations of CKD; and more!