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This book will helpful to the students of cryogenic engineering who are working on Pulse Tube Refrigeration Technology. Objective of the work is to analyze the pulse tube refrigeration process with the help of CFD. To validate CFD methodology by comparing experimental data. To optimize pulse tube refrigeration process by changing geometrical parameters like length and diameter of the inertance tube and valve opening/closing time and operating condition like frequency and mesh size of the regenerator material. The lowest temperature 209.5 K achieved at 1.4 mm diameter and 1 meter length of inertance tube with 0.6/0.4 valve opening/closing time with 300 mesh size of regenerator material at 1.8 Hz operating frequency.