Endocannabinoids have tremendous therapeutic potential. This book introduces readers to our current understanding of the neurobiology of endocannabinoids and related systems, detailing their pathophysiological role and therapeutic potential. Authors, experienced clinical investigators, present and analyze results of recent clinical trials as well as the development of new therapeutic strategies and medicines.
Endocannabinoids have tremendous therapeutic potential. This book introduces readers to our current understanding of the neurobiology of endocannabinoids and related systems, detailing their pathophysiological role and therapeutic potential. Authors, experienced clinical investigators, present and analyze results of recent clinical trials as well as the development of new therapeutic strategies and medicines.
Molecular Biology, Pharmacology, Anatomy, and Physiology of the Endocannabinoid and Related Lipidergic Signaling Systems in the Brain.- An Historical Introduction to the Endocannabinoid and Endovanilloid Systems.- Biosynthesis of Anandamide and 2-Arachidonoylglycerol.- Removal of Endocannabinoids by the Body: Mechanisms and Therapeutic Possibilities.- Other Cannabimimetic Lipid Signaling Molecules.- CB1 Cannabinoid Receptors: Molecular Biology, Second Messenger Coupling and Polarized Trafficking in Neurons.- CB2 Cannabinoid Receptors: Molecular, Signaling, and Trafficking Properties.- CB1 and CB2 Receptor Pharmacology.- Functional Molecular Biology of the TRPV1 Ion Channel.- Alternative Interacting Sites and Novel Receptors for Cannabinoid Ligands.- Anatomical Distribution of Receptors, Ligands and Enzymes in the Brain and in the Spinal Cord: Circuitries and Neurochemistry.- Endocannabinoids at the Synapse: Retrograde Signaling and Presynaptic Plasticity in the Brain.- Endocannabinoid Functions in Neurogenesis, Neuronal Migration, and Specification.- The Endocannabinoid System in Clinical Neuroscience and Experimental Neuropsychiatry.- Cannabinoids in the Management of Nausea and Vomiting.- Endocannabinoids in Energy Homeostasis and Metabolic Disorders.- Cannabinoids and Neuroprotection.- Neuroinflammation and the Glial Endocannabinoid System.- Targeting Cannabinoid Receptors in Brain Tumors.- Cannabinoids for the Control of multiple Sclerosis.- Endocannabinoids in Alzheimer's Disease.- The Endocannabinoid System as a Therapeutic Target in Epilepsy.- The Endocannabinoid System in the Physiology and Pathology of the Basal Ganglia.- The Endocannabinoid System is a Major Player in Schizophrenia.- The Cannabinoid Controversy: Cannabinoid Agonists and Antagonists as Potential Novel Therapies for Mood Disorders.- Role of Cannabinoid Receptors in Anxiety Disorders.
Molecular Biology, Pharmacology, Anatomy, and Physiology of the Endocannabinoid and Related Lipidergic Signaling Systems in the Brain.- An Historical Introduction to the Endocannabinoid and Endovanilloid Systems.- Biosynthesis of Anandamide and 2-Arachidonoylglycerol.- Removal of Endocannabinoids by the Body: Mechanisms and Therapeutic Possibilities.- Other Cannabimimetic Lipid Signaling Molecules.- CB1 Cannabinoid Receptors: Molecular Biology, Second Messenger Coupling and Polarized Trafficking in Neurons.- CB2 Cannabinoid Receptors: Molecular, Signaling, and Trafficking Properties.- CB1 and CB2 Receptor Pharmacology.- Functional Molecular Biology of the TRPV1 Ion Channel.- Alternative Interacting Sites and Novel Receptors for Cannabinoid Ligands.- Anatomical Distribution of Receptors, Ligands and Enzymes in the Brain and in the Spinal Cord: Circuitries and Neurochemistry.- Endocannabinoids at the Synapse: Retrograde Signaling and Presynaptic Plasticity in the Brain.- Endocannabinoid Functions in Neurogenesis, Neuronal Migration, and Specification.- The Endocannabinoid System in Clinical Neuroscience and Experimental Neuropsychiatry.- Cannabinoids in the Management of Nausea and Vomiting.- Endocannabinoids in Energy Homeostasis and Metabolic Disorders.- Cannabinoids and Neuroprotection.- Neuroinflammation and the Glial Endocannabinoid System.- Targeting Cannabinoid Receptors in Brain Tumors.- Cannabinoids for the Control of multiple Sclerosis.- Endocannabinoids in Alzheimer's Disease.- The Endocannabinoid System as a Therapeutic Target in Epilepsy.- The Endocannabinoid System in the Physiology and Pathology of the Basal Ganglia.- The Endocannabinoid System is a Major Player in Schizophrenia.- The Cannabinoid Controversy: Cannabinoid Agonists and Antagonists as Potential Novel Therapies for Mood Disorders.- Role of Cannabinoid Receptors in Anxiety Disorders.
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