C-C Bond Forming Reactions Catalyzed by Artificial Metalloenzymes - Chatterjee, Anamitra
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This book represents the detailed work of A. Chatterjee. Inspired by Whitesides, the biotin-(strept)avidin technology has been exploited to localize a biotinylated metal cofactor within (strept)avidin in Ward group. Optimization of the performance of the resulting artificial metalloenzymes is best achieved relying on chemogenetic means: combining a collection of biotinylated organometallic cofactors with a library of streptavidin mutants. Relying on this strategy, artificial metalloenzyme based on the biotin-streptavidin technology have been developed for three C-C bond forming reactions:…mehr

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Produktbeschreibung
This book represents the detailed work of A. Chatterjee. Inspired by Whitesides, the biotin-(strept)avidin technology has been exploited to localize a biotinylated metal cofactor within (strept)avidin in Ward group. Optimization of the performance of the resulting artificial metalloenzymes is best achieved relying on chemogenetic means: combining a collection of biotinylated organometallic cofactors with a library of streptavidin mutants. Relying on this strategy, artificial metalloenzyme based on the biotin-streptavidin technology have been developed for three C-C bond forming reactions: Suzuki cross-coupling, C-H bond activation, and olefin metathesis. A variety of biotinylated N-heterocycliccarbene- (NHC) and bulky phosphine ligands were synthesized and tested with palladium, rhodium and ruthenium catalysts for this purpose.
Autorenporträt
Anamitra Chatterjee received M.Sc. in chemistry from Indian Institute of Technology Bombay, India in 2011 and obtained his Ph.D. in chemistry in 2015 from the University of Basel, Switzerland under the guidance of Prof. Thomas Ward. Currently he is a postdoctoral researcher under Prof. Vidar Jensen at University of Bergen, Norway.