Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. …mehr
Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain.
Dr. Huile Gao received his PhD in Pharmaceutics from School of Pharmacy, Fudan University in 2013 under the supervision of Prof. Xinguo Jiang. Then he joined the West China School of Pharmacy, Sichuan University as an Instructor in July 2013 and was promoted to an Associate Professor in July 2014. Dr. Gao's research interests focus on the design, synthesis, characterization and evaluation of stimuli responsive nanomaterials for drug and imaging probe delivery to improve treatment and diagnosis of human diseases especially tumor and brain diseases. He has published over 50 peer-reviewed articles. His research is supported by National Natural Science Foundation of China (81373337, 81402866), Excellent young scientist foundation of Sichuan University (2015SCU04A14) and 4 other grants. His doctorial dissertation has been awarded as Excellent Doctorial Dissertation of Shanghai in 2015. He was awarded as "Young Excellent Pharmaceutics Scientist? in 2015.
Inhaltsangabe
1. Introduction and overview
Part I Physiology and principles for brain targeting drug delivery
2. Anatomy and physiology of blood-brain barrier
3. Recent progress in blood-brain barrier transportation research
4. In vitro and in vivo models of BBB to evaluate brain targeting drug delivery
Part II Nanoparticles-based brain targeting delivery strategies
5. Receptor-mediated transportation through BBB
6. Carrier-mediated transportation through BBB
7. Brain drug delivery by adsorption-mediated transcytosis
8. Efflux pump inhibition to enhance brain targeting delivery
9. Physically open BBB
10. Nanoparticle systems for nose-to-brain delivery
11. Brain local delivery strategy
Part III Nanoparticles-based brain targeting delivery for CNS disorder management
12.Glioma targeted delivery systems
13.Nanotherapeutic strategies for the treatment of neurodegenerative diseases
14. Savaging brain ischemia by increasing brain uptake of neuroprotectants
Part IV Perspective and pitfalls of nanoparticles-based brain targeting delivery
15. Neurotoxicity concern about the brain targeting delivery systems
16. The intra-brain distribution of brain targeting delivery systems
17. The elimination of brain-targeted nanomaterials
18. Perspective on brain targeting drug delivery systems
