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Dairy cattle production is an integral component of the farming system in Indian agriculture. In a tropical country like India, thermal stress is one of the major factors which significantly affects the productivity of dairy cattle. Thus the development of thermo resilience dairy cattle herd is need of the hour for sustainable dairy cattle production in India. The theme of the monograph is to understand the role of bovine heat shock protein 70 in the regulation of innate immunity through pattern recognition receptors.