1. Introduction, history, microheterogeneity of bound carbohydrates
function of bound carbohydrates
inducible changes in bound carbohydrates
programmed changes in bound carbohydrates
a possible role for bound carbohydrates
2. Sialic acids
distribution of sialic acids in nature
the metabolism of hexamines and sialic acids
metabolic control of hexosamines and sialic acids
asparagine N-glycosylation
processing of lysomal enzymes
biosynthesis of O-linked oligosaccarides
modification of sialic acids
sialidases
genetic metabolic disorders involving sialic acids, glycosidases, bound carbohydrates in malignancy
3. Multidrug resistance, properties of P-glycoprotein
lysomes and multidrug resistance
kinetics of influx and efflux of drugs, modulation of multidrug resistance
the role of lipids in the accumulation of drugs by MDR cells
P-170 and membrane lipids
Overview.
