A bright young star on the medical school faculty, Jason Pearce worries that he'll lose NIH funding as his basic research falters. He signs a contract with a venture capital company that enables him to embark on a study of mice whose memory fails as they age. He discovers that their forgetfulness is due to a defective memory gene; that the loss can be prevented by injecting young mice with the normal memory gene; and that the same type of gene defect increases the risk of Alzheimer's Disease. With approval of his medical school's ethics review board, he launches a randomized clinical trial to…mehr
A bright young star on the medical school faculty, Jason Pearce worries that he'll lose NIH funding as his basic research falters. He signs a contract with a venture capital company that enables him to embark on a study of mice whose memory fails as they age. He discovers that their forgetfulness is due to a defective memory gene; that the loss can be prevented by injecting young mice with the normal memory gene; and that the same type of gene defect increases the risk of Alzheimer's Disease. With approval of his medical school's ethics review board, he launches a randomized clinical trial to see if injection of a normal human memory gene can prevent Alzheimer's Disease. Betsy Matthews, a middle-aged African-American, develops leukemia a year after she receives the injection. A colleague of Jason's discovers that the injected memory gene triggered Betsy's leukemia. Nobody suspects negligence until Janice Polk, a young investigative reporter, asks a question that others had failed to ask. The answer shatters Jason and his family, his medical school, and the venture capital company.
Emeritus Professor, The Johns Hopkins University School of Medicine (since 2001). Previously Professor of Pediatrics, Director of Genetics and Public Policy Studies, and core faculty of the McKusick-Nathans Institute of Genetic Medicine. with appointments in the Departments of Health Policy and Epidemiology in the Johns Hopkins School of Hygiene and Public Health. Member, NIH-DOE Working Group on Ethical, Legal, Social, Implications of the Human Genome Project (1993-1997); Co-Chair, NIH-DOE Task Force on Genetic Testing(1995-1997) Member, Committee on Assessing Genetic Risks, Institute of Medicine (now National Academy of Medicine) (1991-93); Senior Analyst, Office of Technology Assessment, U.S. Congress (1986-1987, on leave from Johns Hopkins;) Senior Analyst, Office of Technology Assessment, U.S. Congress (on leave from Johns Hopkins); Chairman, Committee on Genetics, American Academy of Pediatrics (1983-1987); Secretary, American Society of Human Genetics (1983-1988); Research grants from NIH 1968-2001
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