Bipolar Psychopharmacotherapy
Caring for the Patient
Ed. by Akiskal, Hagop S.; Tohen, Mauricio
Bipolar Psychopharmacotherapy
Caring for the Patient
Ed. by Akiskal, Hagop S.; Tohen, Mauricio
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"If a colleague were to ask me, "What would you recommend I read if I want to become a real expert on bipolarity?" I would respond Bipolar Psychopharmacotherapy: Caring for the Patient." Journal of Bipolar Disorders
And the second edition is even better! Bipolar Psychopharmacotherapy covers both pharmacotherapy and the supportive role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the pharmacological care of women with bipolar disorder, children…mehr
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"If a colleague were to ask me, "What would you recommend I read if I want to become a real expert on bipolarity?" I would respond Bipolar Psychopharmacotherapy: Caring for the Patient."
Journal of Bipolar Disorders
And the second edition is even better! Bipolar Psychopharmacotherapy covers both pharmacotherapy and the supportive role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the pharmacological care of women with bipolar disorder, children and the elderly, as well as bipolar depression and suicide prevention.
The mood swings that characterize bipolar disorder can now be better stabilized in most patients than in the past, but the illness must be carefully managed throughout a person's life. Pharmacotherapy is central to the acute treatment and long-term management and as there are several classes of drugs which are often prescribed concurrently, treatment issues are complex. This essential reference work features critical reviews of the existing literature, plus information on new treatments that have been reported at peer reviewed scientific meetings, often written by the pioneering experts on a particular treatment. The second-generation antipsychotics are now covered in separate chapters to provide in-depth coverage of these agents. There are also new chapters on the pharmacological treatments of mixed states and rapid cycling and novel therapeutic vistas.
Journal of Bipolar Disorders
And the second edition is even better! Bipolar Psychopharmacotherapy covers both pharmacotherapy and the supportive role of psychotherapy, psychoeducation and social approaches to provide a broad integrative philosophy of care for bipolar patients. Extensive coverage is given to special management issues such as the pharmacological care of women with bipolar disorder, children and the elderly, as well as bipolar depression and suicide prevention.
The mood swings that characterize bipolar disorder can now be better stabilized in most patients than in the past, but the illness must be carefully managed throughout a person's life. Pharmacotherapy is central to the acute treatment and long-term management and as there are several classes of drugs which are often prescribed concurrently, treatment issues are complex. This essential reference work features critical reviews of the existing literature, plus information on new treatments that have been reported at peer reviewed scientific meetings, often written by the pioneering experts on a particular treatment. The second-generation antipsychotics are now covered in separate chapters to provide in-depth coverage of these agents. There are also new chapters on the pharmacological treatments of mixed states and rapid cycling and novel therapeutic vistas.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 2. Aufl.
- Seitenzahl: 544
- Erscheinungstermin: 25. April 2011
- Englisch
- Abmessung: 249mm x 175mm x 33mm
- Gewicht: 1080g
- ISBN-13: 9780470747216
- ISBN-10: 0470747218
- Artikelnr.: 33239098
- Verlag: Wiley & Sons
- 2. Aufl.
- Seitenzahl: 544
- Erscheinungstermin: 25. April 2011
- Englisch
- Abmessung: 249mm x 175mm x 33mm
- Gewicht: 1080g
- ISBN-13: 9780470747216
- ISBN-10: 0470747218
- Artikelnr.: 33239098
Hagop Akiskal is Distinguished Professor of Psychiatry and Director of the International Mood Center, San Diego Veterans Administration Medical Center, San Diego, California, USA. He was awarded the Jean Delay prize by the World Psychiatric Association in 2002 for research work that better bridges the gap between biological, psychological and social aspects of psychiatry and mental health. He has received the Gold Medal for Pioneer Research (Society of Biological Psychiatry), the German Anna Monika Prize for Depression, the NARSAD Prize for Affective Disorders, the French Jules Baillarger and the Italian Aretaeus Prizes for his research on the bipolar spectrum. He is Editor-in-Chief of the Journal of Affective Disorders. Mauricio Tohen was appointed to the Krus endowed chair in Psychiatry at the University of Texas Health Science Centre at San Antonio in 2009. He is Chief of the Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Centre, San Antonio, Texas, USA. He is President of the International Society for Bipolar Disorders (2010 - 2012). His research has focused on the clinical epidemiology and psychopharmacological treatments of bipolar disorder. Professor Tohen has over 200 original publications and over 500 book chapters and scientific abstracts. He has co-edited Mood Disorders Across the Lifespan and Textbook of Psychiatric Epidemiology, and has also edited Comorbidity in Affective Disorders.
List of Contributors. Preface to the Second Edition. Chapter 1 The scope of
bipolar disorders (Hagop S. Akiskal). 1.1 Diagnostic and public health
aspects. 1.2 Psychological and social aspects. Chapter 2 Lithium treatment:
Focus on long-term prophylaxis (Paul Grof and Mogens Schou). 2.1
Introduction. 2.2 Cade's pioneering study. 2.3 Discovery of the
prophylactic action of lithium. 2.4 Practical issues. 2.5 Are new and
better prophylactic agents about to oust lithium? 2.6 Combination
treatment. 2.7 Prophylaxis in recurrent depressive disorder. 2.8 The effect
of lithium on the patients' suicidal behavior. 2.9 Benefits of prophylactic
lithium treatment. 2.10 Conclusion. Chapter 3 Valproate: Clinical
pharmacological profile (Charles L. Bowden and Vivek Singh). 3.1 Historical
background. 3.2 Structure-activity relationships. 3.3 Pharmacodynamic
properties. 3.4 Pharmacokinetics and metabolic clearance. 3.5 Serum
concentration and efficacy. 3.6 Efficacy and indications. 3.7 Efficacy in
bipolar disorder. 3.8 Combination strategy in acute mania. 3.9 Prophylaxis
in bipolar disorder. 3.10 Treatment of bipolar depression. 3.11 Valproate
in treatment of bipolar disorder in children and adolescents. 3.12 Use in
bipolar illness comorbid with alcoholism. 3.13 Bipolar disorder comorbid
with ADHD. 3.14 Bipolar disorder comorbid with borderline personality
disorder. 3.15 Adverse effects. 3.16 Comparative adverse effects. 3.17
Adverse effects in combination therapy, compared with monotherapy. 3.18
Adverse effects by bodily system. 3.19 Summary. Chapter 4 Pharmacological
profile and clinical utility of lamotrigine in mood disorders (Marc L.M.
van der Loos, Joseph R. Calabrese, Willem A. Nolen and David J. Muzina).
4.1 Introduction. 4.2 Clinical pharmacology of lamotrigine. 4.3 Lamotrigine
and mood disorders. 4.4 Safety. 4.5 Clinical applications for lamotrigine
in mood disorders. 4.6 Summary. Chapter 5 Carbamazepine and other
anticonvulsants (Heinz Grunze). 5.1 Introduction. 5.2 Conclusions. Chapter
6 Olanzapine in treatment for bipolar disorder (Mauricio Tohen, Giedra
Campbell and Juan-Carlos Gomez). 6.1 Introduction. 6.2 Rationale in the
clinical trial development of olanzapine. 6.3 Efficacy in the treatment of
acute mania. 6.4 Efficacy in the treatment of bipolar depression. 6.5
Efficacy in bipolar maintenance/relapse prevention. 6.6 Safety and
tolerability. 6.7 Summary. Chapter 7 Haloperidol and other first generation
antipsychotics in mania (John Cookson). 7.1 Introduction. 7.2 Acute
tranquillization in mania. 7.3 Sedation is not required for antipsychotics
to improve mania. 7.4 Chlorpromazine in mania. 7.5 Haloperidol in mania.
7.6 Hormone changes and mechanisms of antimanic effects of antipsychotics.
7.7 Antipsychotics as mood stabilizers. 7.8 Placebo-controlled studies in
mania. 7.9 Recent comparative trials without placebo. 7.10
Pharmacoeconomics. 7.11 Conclusions. Chapter 8 Clinical utility of
clozapine in bipolar disorder (V.E. Cosgrove, J.S. Seo, H. Yang and Trisha
Suppes). 8.1 Introduction. 8.2 History. 8.3 Clinical pharmacology of
clozapine. 8.4 Clozapine in bipolar disorders. 8.5 Effective
pharmacotherapy for bipolar disorder? 8.6 Case studies. Chapter 9
Risperidone and paliperidone in the treatment of bipolar disorder (L. Ivo
Caers and Joris Berwaerts). 9.1 Introduction. 9.2 Oral risperidone in
bipolar mania. 9.3 Paliperidone extended release (ER) in bipolar mania. 9.4
Risperidone long-acting injectable (LAI) in the maintenance treatment of
bipolar disorder. 9.5 Elements of special interest. 9.6 Summary and
conclusions. Chapter 10 Quetiapine in bipolar disorder (Mauricio Kunz,
Svante Nyberg and Lakshmi N. Yatham). 10.1 Introduction. 10.2 Pharmacology.
10.3 Quetiapine in the treatment of acute mania. 10.4 Quetiapine in the
treatment of acute bipolar depression. 10.5 Quetiapine in the maintenance
treatment of bipolar disorder. 10.6 Safety and tolerability of quetiapine.
10.7 Summary. Chapter 11 Ziprasidone in the treatment of bipolar disorder
(Thomas L. Schwartz, Stephen M. Stahl, Elizabeth Pappadopulos and Onur N.
Karayal). 11.1 Introduction. 11.2 Ziprasidone and its proposed mechanism of
action. 11.3 Ziprasidone in treatment guidelines. 11.4 Overview of
ziprasidone efficacy from clinical trial data. 11.5 Acute manic/mixed
episodes. 11.6 Acute depressive episodes. 11.7 Long term maintenance
treatment of bipolar disorder. 11.8 Practical guidance on the use of
ziprasidone in bipolar disorder. 11.9 Safety and tolerability. 11.10
Treatment of special populations. 11.11 Summary and conclusions. Chapter 12
Aripiprazole in bipolar disorder (Alessandra Nivoli and Eduard Vieta). 12.1
Aripiprazole and its mode of action. 12.2 Aripiprazole in treatment
guidelines. 12.3 Aripiprazole efficacy from clinical trial data. 12.4
Aripiprazole safety and tolerability. 12.5 Treatment of special
populations. 12.6 Pharmacogenetics of aripiprazole. Chapter 13 Asenapine in
bipolar disorder (Roger S. McIntyre). 13.1 Introduction. 13.2 Pharmacology.
13.3 Human pharmacokinetics. 13.4 Asenapine: Efficacy in bipolar mania and
mixed states. 13.5 Asenapine: Efficacy and tolerability during extension
treatment. 13.6 Summary and conclusion. Chapter 14 Complex combination
therapy for long-term stability in bipolar disorder (Robert M. Post). 14.1
Introduction. 14.2 Rationale for complex combination therapy in bipolar
illness. 14.3 Principles of building an effective therapeutic regimen. 14.4
Conclusions. Chapter 15 The role of antidepressants in bipolar disorder
(Boghos I. Yerevanian). 15.1 Introduction. 15.2 Tricyclic antidepressants.
15.3 MAO inhibitors. 15.4 SSRIs. 15.5 SNRIs: Venlafaxine, mirtazapine,
duloxetine. 15.6 Bupropion. 15.7 Clinical and research implications.
Chapter 16 Bipolarity in women: Therapeutic issues (Susan L. McElroy,
Lesley M. Arnold and Lori L. Altshuler). 16.1 Introduction. 16.2
Epidemiology and gender distribution of the bipolar spectrum. 16.3 Gender
differences in phenomenology. 16.4 Gender differences in course and
outcome. 16.5 Gender differences in comorbidity. 16.6 Bipolar disorder and
the reproductive cycle. 16.7 Treatment of bipolar disorder in females. 16.8
Summary. Chapter 17 Pediatric bipolar disorder: The promise of
psychopharmacotherapy (Tiffany Thomas and Robert L. Findling). 17.1
Introduction. 17.2 Lithium. 17.3 Anticonvulsants. 17.4 Antipsychotics. 17.5
Conclusion. Chapter 18 Treatment of bipolar disorder in old age (Kenneth I.
Shulman, Nathan Herrmann and Martha Sajatovic). 18.1 Treatment of bipolar
disorder in old age. 18.2 Management of bipolar disorder in the elderly.
18.3 Treatment of bipolar depression in older adults. 18.4 The future.
Chapter 19 Diagnosis and treatment of mixed states (Alan C. Swann). 19.1
What is a mixed state? 19.2 General considerations for treatment strategies
in mixed states. 19.3 Treating mania in mixed states. 19.4 Treating
depression in mixed states. 19.5 Nonpharmacological treatments. 19.6 An
Integrated model for treating mixed states. 19.7 Conclusions. Chapter 20
Rapid cycling of bipolar patients (Athanasios Koukopoulos, G. Serra, F.
Zazzara, A. E. Koukopoulos and G. Sani). 20.1 Introduction. 20.2
Epidemiological data. 20.3 Spontaneous and induced rapid cycling. 20.4
Temperament and rapid cycling. 20.5 Course. 20.6 Clinical picture of rapid
cycling. 20.7 Neurobiology of rapid cycling bipolar disorder: The role of
dopamine D2 receptors, sensitization. 20.8 Treatment. 20.9 Discussion.
Chapter 21 Novel therapeutic approaches for treating bipolar disorder
(Rodrigo Machado-Vieira, Ioline Henter, Jacqueline Baumann, David Latov,
Cristina Wheeler-Castillo and Carlos A. Zarate). 21.1 Introduction. 21.2
The dynorphin opioid neuropeptide system. 21.3 The purinergic system. 21.4
The melatonergic system. 21.5 The glutamatergic system. 21.6 The tachykinin
neuropeptides system. 21.7 The glucocorticoid system. 21.8 The arachidonic
acid (AA) cascade. 21.9 The endocannabinoid system. 21.10 Oxidative stress
and bioenergetics. 21.11 The intracellular signaling pathways. 21.12 Final
remarks. Chapter 22 The pivotal role of psycho-education in the long-term
treatment of bipolar disorder (Francesc Colom and Andrea Murru). 22.1
Introduction. 22.2 On the need for psycho-education. 22.3 The five
ingredients of psycho-education. 22.4 Substance misuse avoidance. 22.5
Early warning signs - detection. 22.6 Lifestyle regularity (and
miscellanea). 22.7 Psycho-education with the family. 22.8 Long-term
follow-up. 22.9 The future. 22.10 Funding sources and acknowledgments.
Chapter 23 The role of treatment setting in the pharmacotherapy of bipolar
disorder (Jean-Michel Azorin). 23.1 Implementation of drug treatment
according to phase and severity of illness. 23.2 Pretreatment evaluation
and monitoring of pharmacotherapy. 23.3 Drug response and treatment
setting. 23.4 From efficacy to efficiency of pharmacotherapy in bipolar
illness. Chapter 24 Pharmacological prevention of suicide in bipolar
patients (Zoltan Rihmer). 24.1 Introduction. 24.2 Mood disorders and
suicidal behavior. 24.3 Risk of suicidal behavior in bipolar disorders.
24.4 Suicide prevention in bipolar disorders. Chapter 25 Overview of
principles of caring for bipolar patients (Hagop S. Akiskal and Kareen K.
Akiskal). 25.1 Introduction. 25.2 The major players in bipolar disorder.
25.3 Principles of caring. 25.4 Special considerations for hypomanic and
cyclothymic patients. 25.5 Conclusion. References. Index.
bipolar disorders (Hagop S. Akiskal). 1.1 Diagnostic and public health
aspects. 1.2 Psychological and social aspects. Chapter 2 Lithium treatment:
Focus on long-term prophylaxis (Paul Grof and Mogens Schou). 2.1
Introduction. 2.2 Cade's pioneering study. 2.3 Discovery of the
prophylactic action of lithium. 2.4 Practical issues. 2.5 Are new and
better prophylactic agents about to oust lithium? 2.6 Combination
treatment. 2.7 Prophylaxis in recurrent depressive disorder. 2.8 The effect
of lithium on the patients' suicidal behavior. 2.9 Benefits of prophylactic
lithium treatment. 2.10 Conclusion. Chapter 3 Valproate: Clinical
pharmacological profile (Charles L. Bowden and Vivek Singh). 3.1 Historical
background. 3.2 Structure-activity relationships. 3.3 Pharmacodynamic
properties. 3.4 Pharmacokinetics and metabolic clearance. 3.5 Serum
concentration and efficacy. 3.6 Efficacy and indications. 3.7 Efficacy in
bipolar disorder. 3.8 Combination strategy in acute mania. 3.9 Prophylaxis
in bipolar disorder. 3.10 Treatment of bipolar depression. 3.11 Valproate
in treatment of bipolar disorder in children and adolescents. 3.12 Use in
bipolar illness comorbid with alcoholism. 3.13 Bipolar disorder comorbid
with ADHD. 3.14 Bipolar disorder comorbid with borderline personality
disorder. 3.15 Adverse effects. 3.16 Comparative adverse effects. 3.17
Adverse effects in combination therapy, compared with monotherapy. 3.18
Adverse effects by bodily system. 3.19 Summary. Chapter 4 Pharmacological
profile and clinical utility of lamotrigine in mood disorders (Marc L.M.
van der Loos, Joseph R. Calabrese, Willem A. Nolen and David J. Muzina).
4.1 Introduction. 4.2 Clinical pharmacology of lamotrigine. 4.3 Lamotrigine
and mood disorders. 4.4 Safety. 4.5 Clinical applications for lamotrigine
in mood disorders. 4.6 Summary. Chapter 5 Carbamazepine and other
anticonvulsants (Heinz Grunze). 5.1 Introduction. 5.2 Conclusions. Chapter
6 Olanzapine in treatment for bipolar disorder (Mauricio Tohen, Giedra
Campbell and Juan-Carlos Gomez). 6.1 Introduction. 6.2 Rationale in the
clinical trial development of olanzapine. 6.3 Efficacy in the treatment of
acute mania. 6.4 Efficacy in the treatment of bipolar depression. 6.5
Efficacy in bipolar maintenance/relapse prevention. 6.6 Safety and
tolerability. 6.7 Summary. Chapter 7 Haloperidol and other first generation
antipsychotics in mania (John Cookson). 7.1 Introduction. 7.2 Acute
tranquillization in mania. 7.3 Sedation is not required for antipsychotics
to improve mania. 7.4 Chlorpromazine in mania. 7.5 Haloperidol in mania.
7.6 Hormone changes and mechanisms of antimanic effects of antipsychotics.
7.7 Antipsychotics as mood stabilizers. 7.8 Placebo-controlled studies in
mania. 7.9 Recent comparative trials without placebo. 7.10
Pharmacoeconomics. 7.11 Conclusions. Chapter 8 Clinical utility of
clozapine in bipolar disorder (V.E. Cosgrove, J.S. Seo, H. Yang and Trisha
Suppes). 8.1 Introduction. 8.2 History. 8.3 Clinical pharmacology of
clozapine. 8.4 Clozapine in bipolar disorders. 8.5 Effective
pharmacotherapy for bipolar disorder? 8.6 Case studies. Chapter 9
Risperidone and paliperidone in the treatment of bipolar disorder (L. Ivo
Caers and Joris Berwaerts). 9.1 Introduction. 9.2 Oral risperidone in
bipolar mania. 9.3 Paliperidone extended release (ER) in bipolar mania. 9.4
Risperidone long-acting injectable (LAI) in the maintenance treatment of
bipolar disorder. 9.5 Elements of special interest. 9.6 Summary and
conclusions. Chapter 10 Quetiapine in bipolar disorder (Mauricio Kunz,
Svante Nyberg and Lakshmi N. Yatham). 10.1 Introduction. 10.2 Pharmacology.
10.3 Quetiapine in the treatment of acute mania. 10.4 Quetiapine in the
treatment of acute bipolar depression. 10.5 Quetiapine in the maintenance
treatment of bipolar disorder. 10.6 Safety and tolerability of quetiapine.
10.7 Summary. Chapter 11 Ziprasidone in the treatment of bipolar disorder
(Thomas L. Schwartz, Stephen M. Stahl, Elizabeth Pappadopulos and Onur N.
Karayal). 11.1 Introduction. 11.2 Ziprasidone and its proposed mechanism of
action. 11.3 Ziprasidone in treatment guidelines. 11.4 Overview of
ziprasidone efficacy from clinical trial data. 11.5 Acute manic/mixed
episodes. 11.6 Acute depressive episodes. 11.7 Long term maintenance
treatment of bipolar disorder. 11.8 Practical guidance on the use of
ziprasidone in bipolar disorder. 11.9 Safety and tolerability. 11.10
Treatment of special populations. 11.11 Summary and conclusions. Chapter 12
Aripiprazole in bipolar disorder (Alessandra Nivoli and Eduard Vieta). 12.1
Aripiprazole and its mode of action. 12.2 Aripiprazole in treatment
guidelines. 12.3 Aripiprazole efficacy from clinical trial data. 12.4
Aripiprazole safety and tolerability. 12.5 Treatment of special
populations. 12.6 Pharmacogenetics of aripiprazole. Chapter 13 Asenapine in
bipolar disorder (Roger S. McIntyre). 13.1 Introduction. 13.2 Pharmacology.
13.3 Human pharmacokinetics. 13.4 Asenapine: Efficacy in bipolar mania and
mixed states. 13.5 Asenapine: Efficacy and tolerability during extension
treatment. 13.6 Summary and conclusion. Chapter 14 Complex combination
therapy for long-term stability in bipolar disorder (Robert M. Post). 14.1
Introduction. 14.2 Rationale for complex combination therapy in bipolar
illness. 14.3 Principles of building an effective therapeutic regimen. 14.4
Conclusions. Chapter 15 The role of antidepressants in bipolar disorder
(Boghos I. Yerevanian). 15.1 Introduction. 15.2 Tricyclic antidepressants.
15.3 MAO inhibitors. 15.4 SSRIs. 15.5 SNRIs: Venlafaxine, mirtazapine,
duloxetine. 15.6 Bupropion. 15.7 Clinical and research implications.
Chapter 16 Bipolarity in women: Therapeutic issues (Susan L. McElroy,
Lesley M. Arnold and Lori L. Altshuler). 16.1 Introduction. 16.2
Epidemiology and gender distribution of the bipolar spectrum. 16.3 Gender
differences in phenomenology. 16.4 Gender differences in course and
outcome. 16.5 Gender differences in comorbidity. 16.6 Bipolar disorder and
the reproductive cycle. 16.7 Treatment of bipolar disorder in females. 16.8
Summary. Chapter 17 Pediatric bipolar disorder: The promise of
psychopharmacotherapy (Tiffany Thomas and Robert L. Findling). 17.1
Introduction. 17.2 Lithium. 17.3 Anticonvulsants. 17.4 Antipsychotics. 17.5
Conclusion. Chapter 18 Treatment of bipolar disorder in old age (Kenneth I.
Shulman, Nathan Herrmann and Martha Sajatovic). 18.1 Treatment of bipolar
disorder in old age. 18.2 Management of bipolar disorder in the elderly.
18.3 Treatment of bipolar depression in older adults. 18.4 The future.
Chapter 19 Diagnosis and treatment of mixed states (Alan C. Swann). 19.1
What is a mixed state? 19.2 General considerations for treatment strategies
in mixed states. 19.3 Treating mania in mixed states. 19.4 Treating
depression in mixed states. 19.5 Nonpharmacological treatments. 19.6 An
Integrated model for treating mixed states. 19.7 Conclusions. Chapter 20
Rapid cycling of bipolar patients (Athanasios Koukopoulos, G. Serra, F.
Zazzara, A. E. Koukopoulos and G. Sani). 20.1 Introduction. 20.2
Epidemiological data. 20.3 Spontaneous and induced rapid cycling. 20.4
Temperament and rapid cycling. 20.5 Course. 20.6 Clinical picture of rapid
cycling. 20.7 Neurobiology of rapid cycling bipolar disorder: The role of
dopamine D2 receptors, sensitization. 20.8 Treatment. 20.9 Discussion.
Chapter 21 Novel therapeutic approaches for treating bipolar disorder
(Rodrigo Machado-Vieira, Ioline Henter, Jacqueline Baumann, David Latov,
Cristina Wheeler-Castillo and Carlos A. Zarate). 21.1 Introduction. 21.2
The dynorphin opioid neuropeptide system. 21.3 The purinergic system. 21.4
The melatonergic system. 21.5 The glutamatergic system. 21.6 The tachykinin
neuropeptides system. 21.7 The glucocorticoid system. 21.8 The arachidonic
acid (AA) cascade. 21.9 The endocannabinoid system. 21.10 Oxidative stress
and bioenergetics. 21.11 The intracellular signaling pathways. 21.12 Final
remarks. Chapter 22 The pivotal role of psycho-education in the long-term
treatment of bipolar disorder (Francesc Colom and Andrea Murru). 22.1
Introduction. 22.2 On the need for psycho-education. 22.3 The five
ingredients of psycho-education. 22.4 Substance misuse avoidance. 22.5
Early warning signs - detection. 22.6 Lifestyle regularity (and
miscellanea). 22.7 Psycho-education with the family. 22.8 Long-term
follow-up. 22.9 The future. 22.10 Funding sources and acknowledgments.
Chapter 23 The role of treatment setting in the pharmacotherapy of bipolar
disorder (Jean-Michel Azorin). 23.1 Implementation of drug treatment
according to phase and severity of illness. 23.2 Pretreatment evaluation
and monitoring of pharmacotherapy. 23.3 Drug response and treatment
setting. 23.4 From efficacy to efficiency of pharmacotherapy in bipolar
illness. Chapter 24 Pharmacological prevention of suicide in bipolar
patients (Zoltan Rihmer). 24.1 Introduction. 24.2 Mood disorders and
suicidal behavior. 24.3 Risk of suicidal behavior in bipolar disorders.
24.4 Suicide prevention in bipolar disorders. Chapter 25 Overview of
principles of caring for bipolar patients (Hagop S. Akiskal and Kareen K.
Akiskal). 25.1 Introduction. 25.2 The major players in bipolar disorder.
25.3 Principles of caring. 25.4 Special considerations for hypomanic and
cyclothymic patients. 25.5 Conclusion. References. Index.
List of Contributors. Preface to the Second Edition. Chapter 1 The scope of
bipolar disorders (Hagop S. Akiskal). 1.1 Diagnostic and public health
aspects. 1.2 Psychological and social aspects. Chapter 2 Lithium treatment:
Focus on long-term prophylaxis (Paul Grof and Mogens Schou). 2.1
Introduction. 2.2 Cade's pioneering study. 2.3 Discovery of the
prophylactic action of lithium. 2.4 Practical issues. 2.5 Are new and
better prophylactic agents about to oust lithium? 2.6 Combination
treatment. 2.7 Prophylaxis in recurrent depressive disorder. 2.8 The effect
of lithium on the patients' suicidal behavior. 2.9 Benefits of prophylactic
lithium treatment. 2.10 Conclusion. Chapter 3 Valproate: Clinical
pharmacological profile (Charles L. Bowden and Vivek Singh). 3.1 Historical
background. 3.2 Structure-activity relationships. 3.3 Pharmacodynamic
properties. 3.4 Pharmacokinetics and metabolic clearance. 3.5 Serum
concentration and efficacy. 3.6 Efficacy and indications. 3.7 Efficacy in
bipolar disorder. 3.8 Combination strategy in acute mania. 3.9 Prophylaxis
in bipolar disorder. 3.10 Treatment of bipolar depression. 3.11 Valproate
in treatment of bipolar disorder in children and adolescents. 3.12 Use in
bipolar illness comorbid with alcoholism. 3.13 Bipolar disorder comorbid
with ADHD. 3.14 Bipolar disorder comorbid with borderline personality
disorder. 3.15 Adverse effects. 3.16 Comparative adverse effects. 3.17
Adverse effects in combination therapy, compared with monotherapy. 3.18
Adverse effects by bodily system. 3.19 Summary. Chapter 4 Pharmacological
profile and clinical utility of lamotrigine in mood disorders (Marc L.M.
van der Loos, Joseph R. Calabrese, Willem A. Nolen and David J. Muzina).
4.1 Introduction. 4.2 Clinical pharmacology of lamotrigine. 4.3 Lamotrigine
and mood disorders. 4.4 Safety. 4.5 Clinical applications for lamotrigine
in mood disorders. 4.6 Summary. Chapter 5 Carbamazepine and other
anticonvulsants (Heinz Grunze). 5.1 Introduction. 5.2 Conclusions. Chapter
6 Olanzapine in treatment for bipolar disorder (Mauricio Tohen, Giedra
Campbell and Juan-Carlos Gomez). 6.1 Introduction. 6.2 Rationale in the
clinical trial development of olanzapine. 6.3 Efficacy in the treatment of
acute mania. 6.4 Efficacy in the treatment of bipolar depression. 6.5
Efficacy in bipolar maintenance/relapse prevention. 6.6 Safety and
tolerability. 6.7 Summary. Chapter 7 Haloperidol and other first generation
antipsychotics in mania (John Cookson). 7.1 Introduction. 7.2 Acute
tranquillization in mania. 7.3 Sedation is not required for antipsychotics
to improve mania. 7.4 Chlorpromazine in mania. 7.5 Haloperidol in mania.
7.6 Hormone changes and mechanisms of antimanic effects of antipsychotics.
7.7 Antipsychotics as mood stabilizers. 7.8 Placebo-controlled studies in
mania. 7.9 Recent comparative trials without placebo. 7.10
Pharmacoeconomics. 7.11 Conclusions. Chapter 8 Clinical utility of
clozapine in bipolar disorder (V.E. Cosgrove, J.S. Seo, H. Yang and Trisha
Suppes). 8.1 Introduction. 8.2 History. 8.3 Clinical pharmacology of
clozapine. 8.4 Clozapine in bipolar disorders. 8.5 Effective
pharmacotherapy for bipolar disorder? 8.6 Case studies. Chapter 9
Risperidone and paliperidone in the treatment of bipolar disorder (L. Ivo
Caers and Joris Berwaerts). 9.1 Introduction. 9.2 Oral risperidone in
bipolar mania. 9.3 Paliperidone extended release (ER) in bipolar mania. 9.4
Risperidone long-acting injectable (LAI) in the maintenance treatment of
bipolar disorder. 9.5 Elements of special interest. 9.6 Summary and
conclusions. Chapter 10 Quetiapine in bipolar disorder (Mauricio Kunz,
Svante Nyberg and Lakshmi N. Yatham). 10.1 Introduction. 10.2 Pharmacology.
10.3 Quetiapine in the treatment of acute mania. 10.4 Quetiapine in the
treatment of acute bipolar depression. 10.5 Quetiapine in the maintenance
treatment of bipolar disorder. 10.6 Safety and tolerability of quetiapine.
10.7 Summary. Chapter 11 Ziprasidone in the treatment of bipolar disorder
(Thomas L. Schwartz, Stephen M. Stahl, Elizabeth Pappadopulos and Onur N.
Karayal). 11.1 Introduction. 11.2 Ziprasidone and its proposed mechanism of
action. 11.3 Ziprasidone in treatment guidelines. 11.4 Overview of
ziprasidone efficacy from clinical trial data. 11.5 Acute manic/mixed
episodes. 11.6 Acute depressive episodes. 11.7 Long term maintenance
treatment of bipolar disorder. 11.8 Practical guidance on the use of
ziprasidone in bipolar disorder. 11.9 Safety and tolerability. 11.10
Treatment of special populations. 11.11 Summary and conclusions. Chapter 12
Aripiprazole in bipolar disorder (Alessandra Nivoli and Eduard Vieta). 12.1
Aripiprazole and its mode of action. 12.2 Aripiprazole in treatment
guidelines. 12.3 Aripiprazole efficacy from clinical trial data. 12.4
Aripiprazole safety and tolerability. 12.5 Treatment of special
populations. 12.6 Pharmacogenetics of aripiprazole. Chapter 13 Asenapine in
bipolar disorder (Roger S. McIntyre). 13.1 Introduction. 13.2 Pharmacology.
13.3 Human pharmacokinetics. 13.4 Asenapine: Efficacy in bipolar mania and
mixed states. 13.5 Asenapine: Efficacy and tolerability during extension
treatment. 13.6 Summary and conclusion. Chapter 14 Complex combination
therapy for long-term stability in bipolar disorder (Robert M. Post). 14.1
Introduction. 14.2 Rationale for complex combination therapy in bipolar
illness. 14.3 Principles of building an effective therapeutic regimen. 14.4
Conclusions. Chapter 15 The role of antidepressants in bipolar disorder
(Boghos I. Yerevanian). 15.1 Introduction. 15.2 Tricyclic antidepressants.
15.3 MAO inhibitors. 15.4 SSRIs. 15.5 SNRIs: Venlafaxine, mirtazapine,
duloxetine. 15.6 Bupropion. 15.7 Clinical and research implications.
Chapter 16 Bipolarity in women: Therapeutic issues (Susan L. McElroy,
Lesley M. Arnold and Lori L. Altshuler). 16.1 Introduction. 16.2
Epidemiology and gender distribution of the bipolar spectrum. 16.3 Gender
differences in phenomenology. 16.4 Gender differences in course and
outcome. 16.5 Gender differences in comorbidity. 16.6 Bipolar disorder and
the reproductive cycle. 16.7 Treatment of bipolar disorder in females. 16.8
Summary. Chapter 17 Pediatric bipolar disorder: The promise of
psychopharmacotherapy (Tiffany Thomas and Robert L. Findling). 17.1
Introduction. 17.2 Lithium. 17.3 Anticonvulsants. 17.4 Antipsychotics. 17.5
Conclusion. Chapter 18 Treatment of bipolar disorder in old age (Kenneth I.
Shulman, Nathan Herrmann and Martha Sajatovic). 18.1 Treatment of bipolar
disorder in old age. 18.2 Management of bipolar disorder in the elderly.
18.3 Treatment of bipolar depression in older adults. 18.4 The future.
Chapter 19 Diagnosis and treatment of mixed states (Alan C. Swann). 19.1
What is a mixed state? 19.2 General considerations for treatment strategies
in mixed states. 19.3 Treating mania in mixed states. 19.4 Treating
depression in mixed states. 19.5 Nonpharmacological treatments. 19.6 An
Integrated model for treating mixed states. 19.7 Conclusions. Chapter 20
Rapid cycling of bipolar patients (Athanasios Koukopoulos, G. Serra, F.
Zazzara, A. E. Koukopoulos and G. Sani). 20.1 Introduction. 20.2
Epidemiological data. 20.3 Spontaneous and induced rapid cycling. 20.4
Temperament and rapid cycling. 20.5 Course. 20.6 Clinical picture of rapid
cycling. 20.7 Neurobiology of rapid cycling bipolar disorder: The role of
dopamine D2 receptors, sensitization. 20.8 Treatment. 20.9 Discussion.
Chapter 21 Novel therapeutic approaches for treating bipolar disorder
(Rodrigo Machado-Vieira, Ioline Henter, Jacqueline Baumann, David Latov,
Cristina Wheeler-Castillo and Carlos A. Zarate). 21.1 Introduction. 21.2
The dynorphin opioid neuropeptide system. 21.3 The purinergic system. 21.4
The melatonergic system. 21.5 The glutamatergic system. 21.6 The tachykinin
neuropeptides system. 21.7 The glucocorticoid system. 21.8 The arachidonic
acid (AA) cascade. 21.9 The endocannabinoid system. 21.10 Oxidative stress
and bioenergetics. 21.11 The intracellular signaling pathways. 21.12 Final
remarks. Chapter 22 The pivotal role of psycho-education in the long-term
treatment of bipolar disorder (Francesc Colom and Andrea Murru). 22.1
Introduction. 22.2 On the need for psycho-education. 22.3 The five
ingredients of psycho-education. 22.4 Substance misuse avoidance. 22.5
Early warning signs - detection. 22.6 Lifestyle regularity (and
miscellanea). 22.7 Psycho-education with the family. 22.8 Long-term
follow-up. 22.9 The future. 22.10 Funding sources and acknowledgments.
Chapter 23 The role of treatment setting in the pharmacotherapy of bipolar
disorder (Jean-Michel Azorin). 23.1 Implementation of drug treatment
according to phase and severity of illness. 23.2 Pretreatment evaluation
and monitoring of pharmacotherapy. 23.3 Drug response and treatment
setting. 23.4 From efficacy to efficiency of pharmacotherapy in bipolar
illness. Chapter 24 Pharmacological prevention of suicide in bipolar
patients (Zoltan Rihmer). 24.1 Introduction. 24.2 Mood disorders and
suicidal behavior. 24.3 Risk of suicidal behavior in bipolar disorders.
24.4 Suicide prevention in bipolar disorders. Chapter 25 Overview of
principles of caring for bipolar patients (Hagop S. Akiskal and Kareen K.
Akiskal). 25.1 Introduction. 25.2 The major players in bipolar disorder.
25.3 Principles of caring. 25.4 Special considerations for hypomanic and
cyclothymic patients. 25.5 Conclusion. References. Index.
bipolar disorders (Hagop S. Akiskal). 1.1 Diagnostic and public health
aspects. 1.2 Psychological and social aspects. Chapter 2 Lithium treatment:
Focus on long-term prophylaxis (Paul Grof and Mogens Schou). 2.1
Introduction. 2.2 Cade's pioneering study. 2.3 Discovery of the
prophylactic action of lithium. 2.4 Practical issues. 2.5 Are new and
better prophylactic agents about to oust lithium? 2.6 Combination
treatment. 2.7 Prophylaxis in recurrent depressive disorder. 2.8 The effect
of lithium on the patients' suicidal behavior. 2.9 Benefits of prophylactic
lithium treatment. 2.10 Conclusion. Chapter 3 Valproate: Clinical
pharmacological profile (Charles L. Bowden and Vivek Singh). 3.1 Historical
background. 3.2 Structure-activity relationships. 3.3 Pharmacodynamic
properties. 3.4 Pharmacokinetics and metabolic clearance. 3.5 Serum
concentration and efficacy. 3.6 Efficacy and indications. 3.7 Efficacy in
bipolar disorder. 3.8 Combination strategy in acute mania. 3.9 Prophylaxis
in bipolar disorder. 3.10 Treatment of bipolar depression. 3.11 Valproate
in treatment of bipolar disorder in children and adolescents. 3.12 Use in
bipolar illness comorbid with alcoholism. 3.13 Bipolar disorder comorbid
with ADHD. 3.14 Bipolar disorder comorbid with borderline personality
disorder. 3.15 Adverse effects. 3.16 Comparative adverse effects. 3.17
Adverse effects in combination therapy, compared with monotherapy. 3.18
Adverse effects by bodily system. 3.19 Summary. Chapter 4 Pharmacological
profile and clinical utility of lamotrigine in mood disorders (Marc L.M.
van der Loos, Joseph R. Calabrese, Willem A. Nolen and David J. Muzina).
4.1 Introduction. 4.2 Clinical pharmacology of lamotrigine. 4.3 Lamotrigine
and mood disorders. 4.4 Safety. 4.5 Clinical applications for lamotrigine
in mood disorders. 4.6 Summary. Chapter 5 Carbamazepine and other
anticonvulsants (Heinz Grunze). 5.1 Introduction. 5.2 Conclusions. Chapter
6 Olanzapine in treatment for bipolar disorder (Mauricio Tohen, Giedra
Campbell and Juan-Carlos Gomez). 6.1 Introduction. 6.2 Rationale in the
clinical trial development of olanzapine. 6.3 Efficacy in the treatment of
acute mania. 6.4 Efficacy in the treatment of bipolar depression. 6.5
Efficacy in bipolar maintenance/relapse prevention. 6.6 Safety and
tolerability. 6.7 Summary. Chapter 7 Haloperidol and other first generation
antipsychotics in mania (John Cookson). 7.1 Introduction. 7.2 Acute
tranquillization in mania. 7.3 Sedation is not required for antipsychotics
to improve mania. 7.4 Chlorpromazine in mania. 7.5 Haloperidol in mania.
7.6 Hormone changes and mechanisms of antimanic effects of antipsychotics.
7.7 Antipsychotics as mood stabilizers. 7.8 Placebo-controlled studies in
mania. 7.9 Recent comparative trials without placebo. 7.10
Pharmacoeconomics. 7.11 Conclusions. Chapter 8 Clinical utility of
clozapine in bipolar disorder (V.E. Cosgrove, J.S. Seo, H. Yang and Trisha
Suppes). 8.1 Introduction. 8.2 History. 8.3 Clinical pharmacology of
clozapine. 8.4 Clozapine in bipolar disorders. 8.5 Effective
pharmacotherapy for bipolar disorder? 8.6 Case studies. Chapter 9
Risperidone and paliperidone in the treatment of bipolar disorder (L. Ivo
Caers and Joris Berwaerts). 9.1 Introduction. 9.2 Oral risperidone in
bipolar mania. 9.3 Paliperidone extended release (ER) in bipolar mania. 9.4
Risperidone long-acting injectable (LAI) in the maintenance treatment of
bipolar disorder. 9.5 Elements of special interest. 9.6 Summary and
conclusions. Chapter 10 Quetiapine in bipolar disorder (Mauricio Kunz,
Svante Nyberg and Lakshmi N. Yatham). 10.1 Introduction. 10.2 Pharmacology.
10.3 Quetiapine in the treatment of acute mania. 10.4 Quetiapine in the
treatment of acute bipolar depression. 10.5 Quetiapine in the maintenance
treatment of bipolar disorder. 10.6 Safety and tolerability of quetiapine.
10.7 Summary. Chapter 11 Ziprasidone in the treatment of bipolar disorder
(Thomas L. Schwartz, Stephen M. Stahl, Elizabeth Pappadopulos and Onur N.
Karayal). 11.1 Introduction. 11.2 Ziprasidone and its proposed mechanism of
action. 11.3 Ziprasidone in treatment guidelines. 11.4 Overview of
ziprasidone efficacy from clinical trial data. 11.5 Acute manic/mixed
episodes. 11.6 Acute depressive episodes. 11.7 Long term maintenance
treatment of bipolar disorder. 11.8 Practical guidance on the use of
ziprasidone in bipolar disorder. 11.9 Safety and tolerability. 11.10
Treatment of special populations. 11.11 Summary and conclusions. Chapter 12
Aripiprazole in bipolar disorder (Alessandra Nivoli and Eduard Vieta). 12.1
Aripiprazole and its mode of action. 12.2 Aripiprazole in treatment
guidelines. 12.3 Aripiprazole efficacy from clinical trial data. 12.4
Aripiprazole safety and tolerability. 12.5 Treatment of special
populations. 12.6 Pharmacogenetics of aripiprazole. Chapter 13 Asenapine in
bipolar disorder (Roger S. McIntyre). 13.1 Introduction. 13.2 Pharmacology.
13.3 Human pharmacokinetics. 13.4 Asenapine: Efficacy in bipolar mania and
mixed states. 13.5 Asenapine: Efficacy and tolerability during extension
treatment. 13.6 Summary and conclusion. Chapter 14 Complex combination
therapy for long-term stability in bipolar disorder (Robert M. Post). 14.1
Introduction. 14.2 Rationale for complex combination therapy in bipolar
illness. 14.3 Principles of building an effective therapeutic regimen. 14.4
Conclusions. Chapter 15 The role of antidepressants in bipolar disorder
(Boghos I. Yerevanian). 15.1 Introduction. 15.2 Tricyclic antidepressants.
15.3 MAO inhibitors. 15.4 SSRIs. 15.5 SNRIs: Venlafaxine, mirtazapine,
duloxetine. 15.6 Bupropion. 15.7 Clinical and research implications.
Chapter 16 Bipolarity in women: Therapeutic issues (Susan L. McElroy,
Lesley M. Arnold and Lori L. Altshuler). 16.1 Introduction. 16.2
Epidemiology and gender distribution of the bipolar spectrum. 16.3 Gender
differences in phenomenology. 16.4 Gender differences in course and
outcome. 16.5 Gender differences in comorbidity. 16.6 Bipolar disorder and
the reproductive cycle. 16.7 Treatment of bipolar disorder in females. 16.8
Summary. Chapter 17 Pediatric bipolar disorder: The promise of
psychopharmacotherapy (Tiffany Thomas and Robert L. Findling). 17.1
Introduction. 17.2 Lithium. 17.3 Anticonvulsants. 17.4 Antipsychotics. 17.5
Conclusion. Chapter 18 Treatment of bipolar disorder in old age (Kenneth I.
Shulman, Nathan Herrmann and Martha Sajatovic). 18.1 Treatment of bipolar
disorder in old age. 18.2 Management of bipolar disorder in the elderly.
18.3 Treatment of bipolar depression in older adults. 18.4 The future.
Chapter 19 Diagnosis and treatment of mixed states (Alan C. Swann). 19.1
What is a mixed state? 19.2 General considerations for treatment strategies
in mixed states. 19.3 Treating mania in mixed states. 19.4 Treating
depression in mixed states. 19.5 Nonpharmacological treatments. 19.6 An
Integrated model for treating mixed states. 19.7 Conclusions. Chapter 20
Rapid cycling of bipolar patients (Athanasios Koukopoulos, G. Serra, F.
Zazzara, A. E. Koukopoulos and G. Sani). 20.1 Introduction. 20.2
Epidemiological data. 20.3 Spontaneous and induced rapid cycling. 20.4
Temperament and rapid cycling. 20.5 Course. 20.6 Clinical picture of rapid
cycling. 20.7 Neurobiology of rapid cycling bipolar disorder: The role of
dopamine D2 receptors, sensitization. 20.8 Treatment. 20.9 Discussion.
Chapter 21 Novel therapeutic approaches for treating bipolar disorder
(Rodrigo Machado-Vieira, Ioline Henter, Jacqueline Baumann, David Latov,
Cristina Wheeler-Castillo and Carlos A. Zarate). 21.1 Introduction. 21.2
The dynorphin opioid neuropeptide system. 21.3 The purinergic system. 21.4
The melatonergic system. 21.5 The glutamatergic system. 21.6 The tachykinin
neuropeptides system. 21.7 The glucocorticoid system. 21.8 The arachidonic
acid (AA) cascade. 21.9 The endocannabinoid system. 21.10 Oxidative stress
and bioenergetics. 21.11 The intracellular signaling pathways. 21.12 Final
remarks. Chapter 22 The pivotal role of psycho-education in the long-term
treatment of bipolar disorder (Francesc Colom and Andrea Murru). 22.1
Introduction. 22.2 On the need for psycho-education. 22.3 The five
ingredients of psycho-education. 22.4 Substance misuse avoidance. 22.5
Early warning signs - detection. 22.6 Lifestyle regularity (and
miscellanea). 22.7 Psycho-education with the family. 22.8 Long-term
follow-up. 22.9 The future. 22.10 Funding sources and acknowledgments.
Chapter 23 The role of treatment setting in the pharmacotherapy of bipolar
disorder (Jean-Michel Azorin). 23.1 Implementation of drug treatment
according to phase and severity of illness. 23.2 Pretreatment evaluation
and monitoring of pharmacotherapy. 23.3 Drug response and treatment
setting. 23.4 From efficacy to efficiency of pharmacotherapy in bipolar
illness. Chapter 24 Pharmacological prevention of suicide in bipolar
patients (Zoltan Rihmer). 24.1 Introduction. 24.2 Mood disorders and
suicidal behavior. 24.3 Risk of suicidal behavior in bipolar disorders.
24.4 Suicide prevention in bipolar disorders. Chapter 25 Overview of
principles of caring for bipolar patients (Hagop S. Akiskal and Kareen K.
Akiskal). 25.1 Introduction. 25.2 The major players in bipolar disorder.
25.3 Principles of caring. 25.4 Special considerations for hypomanic and
cyclothymic patients. 25.5 Conclusion. References. Index.