Review:
'Useful for anyone treating or researching bipolar disorder ... Brings together a great deal of the current thinking and presents it well.' - Doody's Review, September 2005
Table of contents:
Section 1. Do we know the Clinical Course and Epidemiology?
1. The Clinical Epidemiology of Bipolar Disorder: a 35-year Incidence Study in South-East London
Noel Kennedy and Robin M Murray
2. The Functional Outcome of Bipolar Disorder.
Mauricio Tohen and Julie M. Niswander
Section 2. Is Bipolar Disorder a Brain Disease?
3. Brain Abnormalities In Bipolar Disorder: Do They Exist And Do They Change?
E. Serap Monkul and Jair C. Soares
4. Structural MRI Studies In Bipolar Disorder: A Meta-analysis
Colm McDonald, Jolanta Zanelli, Robin Murray and Noel Kennedy
5. Are Subcortical Regions Too Expansive In Bipolar Disorder?
Mary L Phillips
6. The Maudsley Bipolar Project: Insights Into Pathophysiology.
Sophia Frangou
7. Is Any Of This Real? The Word From The Grave
Paul J Harrison
Section 3. Happy Genes, Blue Genes, Any Genes?
8. How Can Bipolar Disorder Be Genetically Related to both Schizophrenia and Unipolar
Depression?
Peter McGuffin
9. Molecular Genetic Factors in Bipolar Disorder.
James Kennedy
10. Is There A Genetic Basis To The Brain Abnormalities Of Bipolar Disorder?
Colm McDonald
11. Transgenic Mouse Models for Affective Disorders based on the Neurotrophin-Hypothesis.
Peter Gass
Section 4. Cortisol: Hero or Villain?
12. Is The Hypothalamic-Pituitary-Adrenal Axis At Last Paying Dividends?
David A. Cousins and Allan H. Young
13. Stress on the Brain: Neuropathology and Cortisol Dysregulation in Bipolar Disorder.
David Cotter
14. Cortisol In Chicago (From Crime Of Passion To Celebrity Headline)
Carmine M. Pariante
15. Biological Factors Sustaining Hypothalamic-Pituitary-Adrenal axis Overactivation in
Affective Disorder: Focus on Vasopressin
Timothy G. Dinan, Sinead OBrien and Lucinda Scott
Section 5. What is the Role of Psychology?
16. Cognitive Dysfunction: Cause Or Consequence Of Bipolar Disorder?
Samuel Robin Chamberlain and Barbara Jacquelyn Sahakian
17. The Neural Basis Of Cognitive Function In Bipolar Disorder
Vivienne Curtis
18. Psychological Treatments: Does the Evidence Stack Up?
Jan Scott
Section 6. Improving the Patients Lot
19. Lithium: The Forgotten Drug
Mario Maj
20. Advantages and Disadvantages of Atypical Antipsychotics or Valproate in Bipolar
Disorder
John Cookson
21. Is Electroconvulsive Therapy Still Given In Bipolar Disorder And Does Repetitive Transcranial Magnetic Stimulation Offer More?
Andrew Mogg, Savitha Eranti, Graham Pluck and Declan M McLoughlin
22. Improving Outcome By Selecting Effective Long-Term Treatment
Paul Grof
23. Is What We Offer To Patients Half-Acceptable?
Rachel Perkins
Based on lectures presented as part of the second European Foundation for Psychiatry at the Maudsley (EFPM) meeting, this modern text focuses on the recent surge in research into the pathogenesis and treatment of bipolar disorder, and critically analyses the evidence supporting many conventional opinions about the disease.
With chapters by leading basic science and clinical researchers from North America and Europe, the book addresses a range of issues, such as:
the very nature of the disease (psychological disorder or brain disease)
the role of genetics
the role of cortisol
the effects of long-term treatment.
Stimulating discussion and debate, this text undoubtedly questions the dogmas of existing practice, challenging conventional views to provide the reader with a fresh, productive perspective on bipolar disorder.
Exploring recent research into the pathogenesis and treatment of bipolar disorder, this text, based on the second European Foundation for Psychiatry at the Maudsley meeting, analyses conventional views to provide a fresh perspective on the disease.
'Useful for anyone treating or researching bipolar disorder ... Brings together a great deal of the current thinking and presents it well.' - Doody's Review, September 2005
Table of contents:
Section 1. Do we know the Clinical Course and Epidemiology?
1. The Clinical Epidemiology of Bipolar Disorder: a 35-year Incidence Study in South-East London
Noel Kennedy and Robin M Murray
2. The Functional Outcome of Bipolar Disorder.
Mauricio Tohen and Julie M. Niswander
Section 2. Is Bipolar Disorder a Brain Disease?
3. Brain Abnormalities In Bipolar Disorder: Do They Exist And Do They Change?
E. Serap Monkul and Jair C. Soares
4. Structural MRI Studies In Bipolar Disorder: A Meta-analysis
Colm McDonald, Jolanta Zanelli, Robin Murray and Noel Kennedy
5. Are Subcortical Regions Too Expansive In Bipolar Disorder?
Mary L Phillips
6. The Maudsley Bipolar Project: Insights Into Pathophysiology.
Sophia Frangou
7. Is Any Of This Real? The Word From The Grave
Paul J Harrison
Section 3. Happy Genes, Blue Genes, Any Genes?
8. How Can Bipolar Disorder Be Genetically Related to both Schizophrenia and Unipolar
Depression?
Peter McGuffin
9. Molecular Genetic Factors in Bipolar Disorder.
James Kennedy
10. Is There A Genetic Basis To The Brain Abnormalities Of Bipolar Disorder?
Colm McDonald
11. Transgenic Mouse Models for Affective Disorders based on the Neurotrophin-Hypothesis.
Peter Gass
Section 4. Cortisol: Hero or Villain?
12. Is The Hypothalamic-Pituitary-Adrenal Axis At Last Paying Dividends?
David A. Cousins and Allan H. Young
13. Stress on the Brain: Neuropathology and Cortisol Dysregulation in Bipolar Disorder.
David Cotter
14. Cortisol In Chicago (From Crime Of Passion To Celebrity Headline)
Carmine M. Pariante
15. Biological Factors Sustaining Hypothalamic-Pituitary-Adrenal axis Overactivation in
Affective Disorder: Focus on Vasopressin
Timothy G. Dinan, Sinead OBrien and Lucinda Scott
Section 5. What is the Role of Psychology?
16. Cognitive Dysfunction: Cause Or Consequence Of Bipolar Disorder?
Samuel Robin Chamberlain and Barbara Jacquelyn Sahakian
17. The Neural Basis Of Cognitive Function In Bipolar Disorder
Vivienne Curtis
18. Psychological Treatments: Does the Evidence Stack Up?
Jan Scott
Section 6. Improving the Patients Lot
19. Lithium: The Forgotten Drug
Mario Maj
20. Advantages and Disadvantages of Atypical Antipsychotics or Valproate in Bipolar
Disorder
John Cookson
21. Is Electroconvulsive Therapy Still Given In Bipolar Disorder And Does Repetitive Transcranial Magnetic Stimulation Offer More?
Andrew Mogg, Savitha Eranti, Graham Pluck and Declan M McLoughlin
22. Improving Outcome By Selecting Effective Long-Term Treatment
Paul Grof
23. Is What We Offer To Patients Half-Acceptable?
Rachel Perkins
Based on lectures presented as part of the second European Foundation for Psychiatry at the Maudsley (EFPM) meeting, this modern text focuses on the recent surge in research into the pathogenesis and treatment of bipolar disorder, and critically analyses the evidence supporting many conventional opinions about the disease.
With chapters by leading basic science and clinical researchers from North America and Europe, the book addresses a range of issues, such as:
the very nature of the disease (psychological disorder or brain disease)
the role of genetics
the role of cortisol
the effects of long-term treatment.
Stimulating discussion and debate, this text undoubtedly questions the dogmas of existing practice, challenging conventional views to provide the reader with a fresh, productive perspective on bipolar disorder.
Exploring recent research into the pathogenesis and treatment of bipolar disorder, this text, based on the second European Foundation for Psychiatry at the Maudsley meeting, analyses conventional views to provide a fresh perspective on the disease.