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Biology of orthodontic tooth movement has always been the topic of interest to the orthodontists. In the present scenario the advancement in the technology has influenced the various working field, orthodontics is nowhere behind. Whether it is a recent advances in diagnosis or treatment planning. As far as orthodontic tooth movements considered the researches are more towards change in cellular and molecular level. This text book focuses on histological aspects of tooth movement, tooth and tissue reaction to various orthodontic forces, also forces leading to root resorption, effect of drugs on the tooth movement, above all clinical application of histological aspect of the tooth movement.