Biological Magnetic Resonance

Volume 2
Herausgegeben:Berliner, Lawrence J.

• Broschiertes Buch

Produktbeschreibung

We are pleased to present this second volume of a series that has already received much interest. The application of magnetic resonance methods to the study of actual biological systems as contrasted to cell-free samples, although not entirely novel, as demonstrated by Civan and Shporer in Volume I, has taken on new dimensions with the use of phosphorus-31 and carbon-13 NMR in studying cells, tissues, and organelles. The applications of 31 P NMR to such systems is reviewed in this volume, while carbon-13 will be covered in a later one. The use of nitroxide spin labels has grown to the point where it now may be considered a common biological technique. The synthesis and applications of a new class of nitroxides is described in this volume. ESR spectroscopy of paramagnetic ions is a powerful approach to studying molecular and structural details, as the chapter by Boas, Pilbrow, and Smith on the ESR of copper in Volume 1 has shown. In this volume the ESR of molybdenum and iron is treated in a comparable fashion. In the first volume some aspects of 1 H NMR spectroscopy of certain classes of In this volume the high-resolu biological macromolecules were discussed.· tion multinuclear NMR spectra of peptides, including the physiologically significant peptide hormones, are reviewed.

Produktdetails

• Biological Magnetic Resonance 2
• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4615-6539-0
• Softcover reprint of the original 1st ed. 1980
• Seitenzahl: 364
• Erscheinungstermin: 30. November 2012
• Englisch
• Abmessung: 229mm x 152mm x 20mm
• Gewicht: 525g
• ISBN-13: 9781461565390
• ISBN-10: 1461565391
• Artikelnr.: 38035528

Autorenporträt

Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR).

Inhaltsangabe

1 Phosphorus NMR of Cells, Tissues, and Organelles.- 1. Introduction.- 2. Methods.- 3. Applications.- 4. Summary.- References.- 2 EPR of Molybdenum-Containing Enzymes.- 1. Introduction.- 2. Enzymes to be Considered and Their General Properties.- 3. Relationship of Molybdenum to Other Constituents in the Enzymes and its Interactions with These Constituents.- 4. Multiple Species of Mo(V) and the Estimation of EPR Parameters.- 5. General Survey of the EPR Parameters of Mo(V) Species in Enzymes.- 6. Discussion of the Parameters.- 7. Conditions Governing Generation and Interconversion of the Signals.- 8. Conclusions on Structures and Enzymatic Mechanisms.- References.- 3 ESR of Iron Proteins.- 1. Introduction.- 2. Electron Spin Resonance Caused by Iron Proteins.- 3. Heme Proteins.- 4. Nonheme Proteins.- References.- 4 Stable Imidazoline Nitroxides.- 1. Introduction.- 2. Synthesis of Imidazoline and Imidazolidine Nitroxides.- 3. Properties of Imidazoline Nitroxides and 1 -Hydroxy-3-imidazolines.- 4. Spectra of Imidazoline Nitroxides.- 5. Magnetic Properties of Imidazoline Nitroxides.- 6. Applications in Analytical and Structural Chemistry.- 7. Imidazoline Spin Labels in Biology.- 8. Syntheses of Some Imidazoline Nitroxides and Important Intermediates.- References.- 5 The Multinuclear NMR Approach to Peptides: Structures, Conformations, and Dynamics.- 1. A Multinuclear Approach.- 2. Chemical Shifts.- 3. Spin-Spin Coupling Constants.- 4. Relaxation Times.- 5. Concluding Remarks.- References.