Everyone has heard of nature's "biological clocks", the phenomenon of periodic activity in plants, animals and humans. But what does chronobiology have to do with modern medicine? This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine. The chapters are written by specialists in the field; they summarize the physiology, pathophysiology and pathology of the human time structure and outline the application of chronobiologic principles and techniques for diagnosis and treatment.
Everyone has heard of nature's "biological clocks", the phenomenon of periodic activity in plants, animals and humans. But what does chronobiology have to do with modern medicine? This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine. The chapters are written by specialists in the field; they summarize the physiology, pathophysiology and pathology of the human time structure and outline the application of chronobiologic principles and techniques for diagnosis and treatment.
I Basic Concepts.- Biologic Rhythms from Biblical to Modern Times. A Preface.- Principles of Clinical Chronobiology.- II Mechanisms of Rhythms.- Cellular and Molecular Aspects of Circadian Oscillators: Models and Mechanisms for Biological Timekeeping.- The Suprachiasmatic Nucleus and Other Pacemakers.- Molecular and Genetic Aspects of Chronobiology.- Seasonal and Daily Control of Enzyme Synthesis and Activity by Circadian Clocks.- III Data Processing.- Data Processing in Chronobiological Studies.- IV Pharmacology and Toxicology.- Chronopharmacology.- Chronotoxicology.- Rhythms in Drug-Induced Teratogenesis.- V Child Development and Aging.- Chronobiology of Pregnancy and the Perinatal Time Span.- Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human.- Rhythms in Biochemical Variables Related to Bone and Their Regulating Hormones.- Biological Rhythms and Aging.- VI Physical and Mental Performance.- Chronobiology of Mental Performance.- Biological, Behavioral and Intellectual Activity Rhythms of the Child During Its Development in Different Educational Environments.- Chronobiology of Physical Performance and Sports Medicine.- VII Shift Work and Transmeridian Flights.- Night and Shift Work and Transmeridian and Space Flights.- VIII Sleep.- Chronobiology of Human Sleep and Sleep Disorders.- IX Psychiatry.- The Complex Circadian Pacemaker in Affective Disorders.- X Endocrine and Metabolic Functions.- Rhythmic and Non-Rhythmic Modes of Anterior Pituitary Hormone Release in Man.- Chronobiology of the Hypothalamic-Pituitary-Adrenal and Renin-Angiotensin-Aldosterone Systems.- Chronobiology of the Hypothalamic-Pituitary-Gonadal Axis in Men and Women.- Chronobiology of the Hypothalamic-Pituitary-Thyroid Axis.- The Pineal.- Chronobiology of Endocrine-Immune Interactions.- Chronobiology, Nutrition, and Diabetes Mellitus.- Endocrine and Neuroendocrine Axis Testing in Clinical Medicine: Evidence for Time Dependency.- XI Hepatobiliary System.- Biological Rhythms in Hepatic Drug Metabolism and Biliary Systems.- XII Gastrointestinal System.- Chronobiology of the Gastrointestinal System.- XIII Cardiovascular System.- Cardiovascular Chronobiology and Chronopharmacology.- Chronobiologic Blood Pressure Assessment from Womb to Tomb.- XIV Respiratory System.- Nocturnal Asthma: Mechanisms and Chronotherapy.- XV Renal Physiology and Pathology.- Renal Excretion: Rhythms in Physiology and Pathology.- XVI Inflammatory Reactions.- Inflammatory Reaction and Disease States.- XVII Immunology and Hematology.- Chronobiology of Immune Functions: Cellular and Humoral Aspects.....- Chronobiology of Circulating Blood Cells and Platelets.- Chronobiology of Human Bone Marrow.- Chronobiology of Polymorphonuclear Leukocyte Migration.- Chronobiology in Hemostastis.- XVIII Cell Proliferation and Cancer.- Normal and Abnormal Cell Proliferation in Mice Especially as It Relates to Cancer.- Chronobiology of Endocrine and Endocrine-Responsive Tumors.- Chronochemotherapy of Malignant Tumors: Temporal Aspects of Antineoplastic Drug Toxicity.- Immune System in Relation to Cancer.- Rhythms in Tumor Markers.- XIX Epidemiology.- Chronoepidemiology: Chronobiology and Epidemiology.- XX Laboratory Medicine.- Chronobiology in Laboratory Medicine.
I Basic Concepts.- Biologic Rhythms from Biblical to Modern Times. A Preface.- Principles of Clinical Chronobiology.- II Mechanisms of Rhythms.- Cellular and Molecular Aspects of Circadian Oscillators: Models and Mechanisms for Biological Timekeeping.- The Suprachiasmatic Nucleus and Other Pacemakers.- Molecular and Genetic Aspects of Chronobiology.- Seasonal and Daily Control of Enzyme Synthesis and Activity by Circadian Clocks.- III Data Processing.- Data Processing in Chronobiological Studies.- IV Pharmacology and Toxicology.- Chronopharmacology.- Chronotoxicology.- Rhythms in Drug-Induced Teratogenesis.- V Child Development and Aging.- Chronobiology of Pregnancy and the Perinatal Time Span.- Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human.- Rhythms in Biochemical Variables Related to Bone and Their Regulating Hormones.- Biological Rhythms and Aging.- VI Physical and Mental Performance.- Chronobiology of Mental Performance.- Biological, Behavioral and Intellectual Activity Rhythms of the Child During Its Development in Different Educational Environments.- Chronobiology of Physical Performance and Sports Medicine.- VII Shift Work and Transmeridian Flights.- Night and Shift Work and Transmeridian and Space Flights.- VIII Sleep.- Chronobiology of Human Sleep and Sleep Disorders.- IX Psychiatry.- The Complex Circadian Pacemaker in Affective Disorders.- X Endocrine and Metabolic Functions.- Rhythmic and Non-Rhythmic Modes of Anterior Pituitary Hormone Release in Man.- Chronobiology of the Hypothalamic-Pituitary-Adrenal and Renin-Angiotensin-Aldosterone Systems.- Chronobiology of the Hypothalamic-Pituitary-Gonadal Axis in Men and Women.- Chronobiology of the Hypothalamic-Pituitary-Thyroid Axis.- The Pineal.- Chronobiology of Endocrine-Immune Interactions.- Chronobiology, Nutrition, and Diabetes Mellitus.- Endocrine and Neuroendocrine Axis Testing in Clinical Medicine: Evidence for Time Dependency.- XI Hepatobiliary System.- Biological Rhythms in Hepatic Drug Metabolism and Biliary Systems.- XII Gastrointestinal System.- Chronobiology of the Gastrointestinal System.- XIII Cardiovascular System.- Cardiovascular Chronobiology and Chronopharmacology.- Chronobiologic Blood Pressure Assessment from Womb to Tomb.- XIV Respiratory System.- Nocturnal Asthma: Mechanisms and Chronotherapy.- XV Renal Physiology and Pathology.- Renal Excretion: Rhythms in Physiology and Pathology.- XVI Inflammatory Reactions.- Inflammatory Reaction and Disease States.- XVII Immunology and Hematology.- Chronobiology of Immune Functions: Cellular and Humoral Aspects.....- Chronobiology of Circulating Blood Cells and Platelets.- Chronobiology of Human Bone Marrow.- Chronobiology of Polymorphonuclear Leukocyte Migration.- Chronobiology in Hemostastis.- XVIII Cell Proliferation and Cancer.- Normal and Abnormal Cell Proliferation in Mice Especially as It Relates to Cancer.- Chronobiology of Endocrine and Endocrine-Responsive Tumors.- Chronochemotherapy of Malignant Tumors: Temporal Aspects of Antineoplastic Drug Toxicity.- Immune System in Relation to Cancer.- Rhythms in Tumor Markers.- XIX Epidemiology.- Chronoepidemiology: Chronobiology and Epidemiology.- XX Laboratory Medicine.- Chronobiology in Laboratory Medicine.
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