Biochemistry of Pulmonary Emphysema

Mitarbeit: Corsico, R.; Herausgegeben von Grassi, C.; Travis, J.; Casali, L.; Luisetti, M.

• Broschiertes Buch

Produktbeschreibung

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

Produktdetails

• Current Topics in Rehabilitation
• Verlag: Springer / Springer, Berlin / Springer, London
• Softcover reprint of the original 1st ed. 1992
• Seitenzahl: 220
• Erscheinungstermin: 9. April 2014
• Englisch
• Abmessung: 244mm x 170mm x 13mm
• Gewicht: 387g
• ISBN-13: 9781447137733
• ISBN-10: 1447137736
• Artikelnr.: 40773168

Inhaltsangabe

From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.