Biochemistry of Diabetes and Atherosclerosis

Herausgegeben von Gilchrist, James S.C.; Tappia, Paramjit; Netticadan, Thomas

• Broschiertes Buch

Produktbeschreibung

Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes.

This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.

Produktdetails

• Developments in Molecular and Cellular Biochemistry .42
• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4613-4852-8
• Softcover reprint of the original 1st ed. 2003
• Seitenzahl: 200
• Erscheinungstermin: 29. Oktober 2012
• Englisch
• Abmessung: 280mm x 210mm x 12mm
• Gewicht: 504g
• ISBN-13: 9781461348528
• ISBN-10: 1461348528
• Artikelnr.: 37480254

Inhaltsangabe

Content.- Preface.- Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative.- Comparative analysis of the phenolic content of selected Chilean, Canadian and American Merlot red wines.- Absence of ischemic preconditioning protection in diabetic sheep hearts: Role of sarcolemmal KATP channel dysfunction.- Protein kinase B in the diabetic heart.- Inhibition of interleukin-1 ? convertase is associated with decrease of neointimal hyperplasia after coronary artery stenting in pigs.- Effects of MCC-135 on Ca2+ uptake by sarcoplasmic reticulum and myofilament sensitivity to Ca2+ in isolated ventricular muscles of rats with diabetic cardiomyopathy.- Effect of sarpogrelate on altered STZ-diabetes induced cardiovascular responses to 5-hydroxytryptamine in rats.- Mitogen-activated protein kinases in the acute diabetic myocardium.- Association between coronary endothelial dysfunction and local inflammation of atherosclerotic coronary arteries.- Arteriosclerosis in rat aortic allografts: Dynamics of cell growth, apoptosis and expression of extracellular matrix proteins.- Effect of chronic treatment with losartan on streptozotocin-induced renal dysfunction.- The relationship between human cytomegalovirus infection and atherosclerosis development.- Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion.- A comparison between NMR and GCMS 13C-isotopomer analysis in cardiac metabolism.- Chronic diabetes alters function and expression of ryanodine receptor calcium-release channels in rat hearts.- The relationship between QTc interval and cardiac autonomie neuropathy in diabetes mellitus.- Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins.- Nativeand minimally oxidized low density lipoprotein depress smooth muscle matrix metalloproteinase levels.- Low matrix metalloproteinase levels precede vascular lesion formation in the JCR:LA-cp rat.- Impairment of glucose metabolism and energy transfer in the rat heart.- Ischemie tolerance of rat hearts in acute and chronic phases of experimental diabetes.- Remodelling of the sarcolemma in diabetic rat hearts: The role of membrane fluidity.- Index to Volume 249.