Bayesian Approaches to Clinical Trials and Health-Care Evaluation - Spiegelhalter, David J; Abrams, Keith R; Myles, Jonathan P
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The Bayesian approach involves synthesising data and judgement in order to reach conclusions about unknown quantities and make predictions. Bayesian methods have become increasingly popular in recent years, notably in medical research, and although there are a number of books on Bayesian analysis, few cover clinical trials and biostatistical applications in any detail. Bayesian Approaches to Clinical Trials and Health-Care Evaluation provides a valuable overview of this rapidly evolving field, including basic Bayesian ideas, prior distributions, clinical trials, observational studies, evidence…mehr

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Produktbeschreibung
The Bayesian approach involves synthesising data and judgement in order to reach conclusions about unknown quantities and make predictions. Bayesian methods have become increasingly popular in recent years, notably in medical research, and although there are a number of books on Bayesian analysis, few cover clinical trials and biostatistical applications in any detail. Bayesian Approaches to Clinical Trials and Health-Care Evaluation provides a valuable overview of this rapidly evolving field, including basic Bayesian ideas, prior distributions, clinical trials, observational studies, evidence synthesis and cost-effectiveness analysis. Covers a broad array of essential topics, building from the basics to more advanced techniques. * Illustrated throughout by detailed case studies and worked examples. * Includes exercises in all chapters. * Accessible to anyone with a basic knowledge of statistics. * Authors are at the forefront of research into Bayesian methods in medical research. * Accompanied by a Web site featuring data sets and worked examples using Excel and WinBUGS - the most widely used Bayesian modelling package. Bayesian Approaches to Clinical Trials and Health-Care Evaluation is suitable for students and researchers in medical statistics, statisticians in the pharmaceutical industry, and anyone involved in conducting clinical trials and assessment of health-care technology.
Autorenporträt
Sir David John Spiegelhalter, OBE FRS, is a British statistician and Winton Professor of the Public Understanding of Risk in the Statistical Laboratory at the University of Cambridge and a Fellow of Churchill College, Cambridge. Spiegelhalter is an ISI highly cited researcher. Keith R. Abrams is the author of Bayesian Approaches to Clinical Trials and Health-Care Evaluation, published by Wiley. Jonathan P. Myles is the author of Bayesian Approaches to Clinical Trials and Health-Care Evaluation, published by Wiley.
Rezensionen
"This is a terrific book and should be on the shelf of everyprofessional that works in clinical trials or health-careevaluation. It gives a thorough pragmatic introduction to Bayesianmethods for health-care interventions, provides many example alongwith data and software to reproduce the analyses, guides readers toareas where Bayesian methods are particularly valuable, andincludes an excellent set of exercises." (Journal of theAmerican Statistical Association, June 2009)

"Bayesian Approaches to Clinical Trials and Health-CareEvaluation' is a clear and comprehensive text for biostatisticianswho want to understand and apply Bayesian statistical methods toclinical research." (Journal of Clinical Best Practices, Nov2008)

"...an indispensable resource for all students andinvestigators who plan to incorporate Bayesian methods into theirresearch." (The Annals of Pharmacotherapy, January 2005)

"...a valuable resource for libraries, and those who areinvolved in quantitative health care evaluation..." (RoyalStatistical Society, Vol.168, No.1, January 2005)

"...The technical material is presented in an accessible style,and the examples given clearly illustrate the principles underdiscussion..." (Short Book Reviews, Vol.24, No.3, December2004)

"...Bayesian analysis seems set to reach a wider audience withthe publication of [this] introductory level text..." (FinancialTimes, 16 April 2004)

"...very well laid-out and easy to follow...a very good resourcefor teaching students..." (Statistical Methods in MedicalResearch, Vol 14, 2005)

"I would use with pleasure and interest this book as atextbook..." (Metron Journal, Vol.63, No.2, 2005)

"...I can pay the authors no higher tribute than to say that Iwould be proud to have written this book. It is elegant and it isdestined to becoming a classic in the field." (Statistics inMedicine, 15th July 2005)

"...a generous supply of exercises...I recommend it veryhighly..." (Clinical Trials, No.1 2004)

"...Bayesian analysis seems set to reach a wider audience withthe publication of [this] introductory level text..." (FinancialTimes, 16 April 2004)

"...a generous supply of exercises...I recommend it veryhighly..." (Clinical Trials, No.1 2004)…mehr