Basic and Clinical Research on Renal Cell Carcinoma

Herausgegeben von Staehler, Gerd; Pomer, Sigmund

• Broschiertes Buch

Produktbeschreibung

Advanced Renal Cell Carcinoma (RCC) cannot be cured bysurgery alone. Its resillience to irradiation andchemotherapy demands a new approach to the management ofthis disease.This bookprovides an overview of the scientific and clinicaldevelopments of RCC,and clarifies the fields ofimmunotherapy andimmunobiology.The book contains a compilation of approaches that willenhance the effectiveness of the management of advancedRCC,even in the absence of definitive pre-clinical data. Theserequire additional study and will stimulate the reassessmentof preliminary results.Furthermore, preliminary resultsof already implemented clinical trials withbiologicalmodifiers are presented. Of special interest are the currentachievements in thefield of immunotherapy using topically and subcutaneouslylow dosage combinations of cytokines.This concise volumewill benefit those seeking a thorough review of the researchand the clinical aspects of RCC simultaneously.

Produktdetails

• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-642-76865-1
• Softcover reprint of the original 1st ed. 1992
• Seitenzahl: 256
• Erscheinungstermin: 16. Dezember 2011
• Englisch
• Abmessung: 235mm x 155mm x 15mm
• Gewicht: 394g
• ISBN-13: 9783642768651
• ISBN-10: 3642768652
• Artikelnr.: 36121371

Inhaltsangabe

Molecular and Cellular Basis of Renal Cell Carcinoma.- Molecular Differential Pathology of Renal Cell Tumors.- Pathobiology of Renal Carcinogenesis.- Molecular Analysis of DNA Sequences on Chromosome 3 in Patients with Renal Cell Carcinoma.- Cell Proliferation and Cellular Heterogeneity in Renal Cell Carcinoma.- 31P NMR Spectroscopy of Human Tumor Cells In Vitro and In Vivo: Prospects for Applications to Renal Cell Carcinoma.- Conservative Surgery of Renal Tumors: Operative Technique, Complications, Results, DNA Cytometry.- Clinical Relevance of Proliferation Rates in Renal Cell Carcinoma.- Chemotherapy of Renal Cell Carcinoma.- Cytotoxic Chemotherapy Phase II Trials Between 1983 and 1990 for Advanced Renal Cell Carcinoma.- Modulation of Multidrug Resistance in Human Renal Cell Carcinomas.- Transgenic Mice Carrying the Human MdR 1 Gene: Reliable In Vivo Probes to Examine Multidrug Resistance.- Adhesion Molecules and Their Possible Influence on Immune Surveillance.- Immunobiology of Renal Cell Carcinoma.- Anti-Proliferative and Anti-Tumor Effect of a-Interferon in Renal Cell Carcinoma: Correlation with the Expression of a Kidney Associated Differentiation Glycoprotein.- Prediction of Cytokine-Therapy on Basis of Class-I and Class-II MHC Antigen Induction.- Alien Gene Transfection and the Immune Response to Tumors.- Active Specific Immunotherapy with Tumor Cells Expressing a Foreign Gene.- Novel Monoclonal Antibody 138H11 Against Human ?-Glutamyl-Transferase: Classification, Histogenesis and Immunoscintigraphy of Renal Tumors.- T-Cell Activation by Bispecific Monoclonal Antibodies for Lysis of Renal Cell Carcinoma In Vitro.- Immunotherapy of Renal Cell Carcinoma.- New Experimental Approaches to the Adoptive Immunotherapy of Cancer: Cytokines, Gene Therapy, Oncogenes andTransgenic Mice.- Cytokines as Possible Adjuvants to Vaccines in Active Specific Immunotherapy for Renal Cell Carcinoma.- Tumor Infiltrating Lymphocytes in Renal Cell Cancer.- Combined Vaccination with Autologous Tumor Material and Subcutaneously Administered rIL-2 and rIFN-?-2b in the Treatment of Renal Cell Carcinoma.- Interleukin-2 by Inhalation: Local Therapy for Metastatic Renal Cell Carcinoma.