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In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Tolga Aksu and Olujimi A. Ajijola bring their considerable expertise to the topic of Autonomic Nervous System and Arrhythmias. Top experts in the field discuss topics such as the role of ANS in atrial fibrillation; the role of ANS in VVS and clinical bradyarrhythmias; the role of ANS in ventricular arrhythmias; pathophysiologic mechanisms in cardiac ANS and arrhythmias; cardiac neuroanatomy; and more. Contains 15 relevant, practice-oriented topics including non-invasive neuromodulation of arrhythmias; experimental neuromodulation of the cardiac ANS; the role of ANS in cardio-renal syndrome; device-based therapies for cardiac neuromodulation; and more. Provides in-depth clinical reviews on the autonomic nervous system and arrhythmias, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.