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This book contains the elaboration of new conceptions or their resignification for the purposes of application in different areas, which requires constant critical reflection and theorization while allowing its return and transforming effect on the human being, where psychologists need to assume the leading role they have in defining the creation of theoretical models that respond to the problems that afflict us today. In order to achieve this goal, the book demystifies the instrumentalist concepts of neutrality, social and political participation in psychology, among others. It is relevant to point out that other social and psychological approaches minimize culturally organized subjectivity. In professional practices, subjectivity occupies an important place in the commitments that the subject assumes and for its study, it is conceptualized as production and not as reflection. The historical-cultural approach, oriented by an integrative vision, is sensitive to the contributions coming from diverse theoretical approaches and thus potentiates the study of the psychological in a coherent, open and flexible manner.