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With interruption of treatment ART can be ineffective, wasteful and dangerous as it can result in hospitalization, new opportunistic infections and premature death. Additionally, the impact of treatment interruptions include increased use of medical resources, drug resistance, some might develop and transmit resistance strains to their spouses and or sexual partners who have been responding well on ART with resultant treatment failure. Treatment interruptions, is also an important factor in drug resistance and treatment failure, it is also a powerful predictor of survival. Therefore, failure to strictly monitor patients to prevent interruption of treatment might compromise patients survival leading to more deaths from the disease.