This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our ancient, innate immunity and our modern adaptive immune system. Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist / immunologist / and scientist with experience in drug development. It covers all cell types involved in…mehr
This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our ancient, innate immunity and our modern adaptive immune system. Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist / immunologist / and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing the latest immunological facts with a focus on drug development. Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists.
Born in 1962, Harald Kropshofer gained his PhD in 1993 from the University of Tbingen. He subsequently did his post-doc at the German Cancer Research Center, Heidelberg, before becoming senior scientist and group leader there in 1997. In 2000 he gained his lecturing qualification at the University of Heidelberg and in the same year joined the Basel Institute for Immunology as the Group leader in Antigen Presentation. He has been working at F. Hoffmann-La Roche, Basel, since 2002, where he is currently Head of Applied Immunology. Dr. Kropshofer is a recipient of, among others, the Otto-Westphal Award from the German Society for Immunology, the Robert-Koch Award for Postdoctoral Scientists, and the Georges-Koehler Award from the German Society for Immunology. He has filed three patents, and has around fifty publications to his name.
Born in 1967, Anne Barbara Vogt gained her doctorate in 1995 from the University of Tbingen, before doing her post-doc at the German Cancer Research Center, Heidelberg. From 2000 to 2001, she was Group leader at the Basel Institute for Immunology, joining F. Hoffmann-La Roche in 2002, where she is currently Group leader at the Roche Center for Medical Genomics. Dr. Vogt is the recipient of several fellowships and of the Langener Wissenschaftspreis from the Paul-Ehrlich Institute and the Georges-Koehler Award, given by the German Society for Immunology. She has filed three patents, and has some 40 publications to her name.
Inhaltsangabe
Introduction Some old and new findings on antigen processing and presentation Antigen entry routes - where foreign invaders meet antigen presenting cells Antigen processing in the context of MHC class I molecules Antigen processing for MHC Class II Antigen processing and presentation by CD1 family proteins Naturally processed self-peptides of MHC molecules Target cell contributions to cytotoxic T cell sensitivity Stimulation of antigen presenting cells: from classical adjuvants to Toll-like receptor (TLR) ligands Evolution and diversity of macrophages Macrophages - Balancing tolerance and immunity Polymorphonuclear neutrophils as antigen-presenting cells Microglial - the professional antigen presenting cells of the CNS? The contribution of B cells to autoimmune pathogenesis Dendritic cells (DCs) in immunity and maintenance of tolerance Thymic dendritic cells Antigen-presenting cells as drug targets Glossary
Introduction Some old and new findings on antigen processing and presentation Antigen entry routes - where foreign invaders meet antigen presenting cells Antigen processing in the context of MHC class I molecules Antigen processing for MHC Class II Antigen processing and presentation by CD1 family proteins Naturally processed self-peptides of MHC molecules Target cell contributions to cytotoxic T cell sensitivity Stimulation of antigen presenting cells: from classical adjuvants to Toll-like receptor (TLR) ligands Evolution and diversity of macrophages Macrophages - Balancing tolerance and immunity Polymorphonuclear neutrophils as antigen-presenting cells Microglial - the professional antigen presenting cells of the CNS? The contribution of B cells to autoimmune pathogenesis Dendritic cells (DCs) in immunity and maintenance of tolerance Thymic dendritic cells Antigen-presenting cells as drug targets Glossary
Rezensionen
"Structured in a clear way to allow access to a very broad readership ...providing the latest immunological facts ... Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists." - Clinical Laboratory
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