Eltayeb Ali

Anti-malaria Drugs and Plasmodium falciparum Gametocytes Prevalence

Gametocyte Prevalence and Drug Resistance following treatment of Uncomplicated Plasmodium falciparum Malaria

• Broschiertes Buch

Produktbeschreibung

We monitored post-treatment Plasmodium falciparum among patients treated with chloroquine (CQ) and Fansidar (SP) in a village in eastern Sudan. Parasites were examined on day0, day7, day14 and day21 during the transmission season. A further sample was taken 2 months later (day80) at the start of the dry season. Asexual forms and gametocytes were detected by microscopy,and reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect expression of gametocyte-specific proteins pfs25 and pfg377. Microscopic gametocytes increased significantly following CQ and SP treatment, reaching a maximum between days7 and14. When measured by RT-PCR, however, there was no significant difference in gametocyte rate between day0 and days7 or 14. RT-PCR gametocyte rates dropped dramatically by day80 post treatment but were still 33% and 8% in the CQ- and SP-treated groups at this time. Drug resistance alleles to CQ (pfcrt,and pfmdr1) and to SP (dhfr) were seen at a high frequency at thebeginning of treatment and increased further through time following both drug treatments. Infections with drug-resistant parasites tended to have higher gametocyte prevalence than drug-sensitive infections

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 136
• Erscheinungstermin: 6. März 2013
• Englisch
• Abmessung: 220mm x 150mm x 9mm
• Gewicht: 221g
• ISBN-13: 9783659357312
• ISBN-10: 3659357316
• Artikelnr.: 37472990

Autorenporträt

Dr. Ali has obtained his PhD in Biochemistry in 2004 from University of Khartoum in collaboration with Edinburgh University. Since then he has established his own laboratory at Sudan Atomic Energy Commission (SAEC) and involved in different research projects jointly with Sudan Academy of Sciences. He is the author of several published articles.