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The side effects of various treatment therapies are there which may cause problem in finding the complete solution for the treatment of certain diseases like cancer. Plants have been used for medicinal purposes from many years back all over the world. Excessive angiogenesis is an important factor of pathogenesis of many diseases. Anti-angiogenesis treatment strategies using anti-angiogenic phytochemicals may show promising results in finding the solution of the problems like drug resistance which generally arise in the other treatment therapies of different diseases.