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Vasculitides associated with anti-neutrophil cytoplasmic antibodies (ANCA) are rare diseases often unrecognized. To describe the epidemiological, clinical, immunological and histological characteristics of ANCA. To specify the therapeutic modalities, the evolutionary profile and the complications during these vasculitides. Retrospective study conducted in the department of internal medicine of Sfax during the period (January 1997-December 2016), including patients with an AAV. Retrospective study conducted in the department of internal medicine of Sfax during the period (January 1997-December 2016), including patients with AAV. Results: Our study includes 23 cases of AAV divided into 14 cases (60.9%) of granulomatosis with polyangiitis (GPA), 7 cases (30.4%) of eosinophilic granulomatosis with polyangiitis (GEPA), 2 cases (8.7%) of microscopic polyangiitis (MAP). There were 15 men (65.2%) and 8 women (34.8%). The mean age was 49.6 years.