Wang

Analysis of Complex Diseases

A Mathematical Perspective

• Gebundenes Buch

Produktbeschreibung

Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, this book presents a holistic perspective for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. It demonstrates the importance of physical thinking and mathematical analysis in understanding complex systems. Taking an interdisciplinary look at this translational subject, the book explains how mathematical modeling and analysis are critical to the future of diagnostics and therapeutics in medicine.

Produktdetails

• Verlag: Taylor & Francis Ltd (Sales)
• Seitenzahl: 230
• Erscheinungstermin: 18. Dezember 2013
• Englisch
• Abmessung: 238mm x 161mm x 20mm
• Gewicht: 462g
• ISBN-13: 9781466572218
• ISBN-10: 1466572213
• Artikelnr.: 38596494

Autorenporträt

Guanyu Wang obtained one PhD (in engineering) from Zhejiang University, China, in 1998 and one PhD (in medical sciences) from the University of Cologne, Germany, in 2005. As a postdoctoral fellow, he was initially at the School of Health Information of the University of Texas Health Science Center at Houston and then at the Department of Bioengineering, Rice University. He was an assistant professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center at Houston and then an assistant professor of Physics at George Washington University. He is now an associate professor of biology at South University of Science and Technology of China, located in the city of Shenzhen.

Inhaltsangabe

Organismal Level: What Is Required. Food Intake and Energy Metabolism.
Glucose Homeostasis. Optimal Glucose Homeostasis. Bistability as a
Fundamental Phenomenon. Molecular Level: What Can Be Provided? Molecular
Biology. Biomolecular Network. PI3K-AKT-TOR Pathway. Mathematical Analysis
of Complex Diseases. Diseases Related to Metabolism. Mathematical Modeling
of the PI3K-AKT-TOR Pathway. Fundamental Decomposition. Normal Phenotype.
Disease Phenotypes. Tao of Diseases. References. Abbreviations. Appendix A
Optimization of Insulin Action. Appendix B Derivation of the Master
Equation of AKT Activation. Appendix C Singularity Theory. Appendix D
Analysis of the Simplified Master Equation. Appendix E Analysis of the
Master Equation. Index.