Mark Ashton, Paul W Groundwater, Sophie Stocker, Adam Todd

An Integrated Guide to Human Drug Metabolism

From Basic Chemical Transformations to Drug-Drug Interactions

• Broschiertes Buch

Produktbeschreibung

An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines, and other drugs. Each of the human metabolic processes are covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (age-related dosage adjustments, routes of administration, and personalized medicines). Appropriate for use in the classroom or for self-study, this book is for students and researchers needing a reference for interdisciplinary research in drug interactions. Metabolism is at the center of personalized medicine, as it is a governing factor in the response of the patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential will be used to highlight the increasing necessity for understanding the genetic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a basis for the discussion of clinical aspects.

Produktdetails

• Verlag: Elsevier Health Sciences
• Seitenzahl: 250
• Erscheinungstermin: 1. Juni 2024
• Englisch
• ISBN-13: 9780323991339
• ISBN-10: 0323991335
• Artikelnr.: 69769064

Autorenporträt

Dr Mark Ashton started his career in the pharmaceutical industry in 2002 working in both medicinal chemistry and process chemistry departments. In 2010, Mark joined the School of Pharmacy at Sunderland University as a Senior Lecturer in Medicinal Chemistry where he taught across a range of both undergraduate and postgraduate chemistry-based degree programmes, including all four stages of the MPharm degree. In 2017 Mark joined the School of Pharmacy at Newcastle University as a lecturer in Medicinal Chemistry where he has overseen the redevelopment of the chemistry strand of the MPharm degree to improve the integration between the science and practice aspects of the degree. His research interests include the development of new antiviral agents and synthetic biology.

Inhaltsangabe

1. Absorption, Distribution, Metabolism and Excretion (ADME)
2. The Clinical Relevance of Metabolism
3. Oxidative Phase I Metabolic Transformations
4. Other Phase I Metabolic Transformations
5. Phase II Metabolic Transformations
6. Phase III Metabolic Processes