Advanced Biomaterials and Biodevices
Herausgegeben von Tiwari, Ashutosh; Nordin, Anis N.
Advanced Biomaterials and Biodevices
Herausgegeben von Tiwari, Ashutosh; Nordin, Anis N.
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This cutting-edge book focuses on the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities
The design and development of biomaterials play a significant role in the diagnosis, treatment, and prevention of diseases. When used with highly selective and sensitive biomaterials, cutting-edge biodevices can allow the rapid and accurate diagnosis of disease, creating a platform for research and development, especially in the field of treatment for prognosis and detection of diseases in the early stage. This book…mehr
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This cutting-edge book focuses on the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities
The design and development of biomaterials play a significant role in the diagnosis, treatment, and prevention of diseases. When used with highly selective and sensitive biomaterials, cutting-edge biodevices can allow the rapid and accurate diagnosis of disease, creating a platform for research and development, especially in the field of treatment for prognosis and detection of diseases in the early stage. This book emphasizes the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities.
The 15 comprehensive chapters written by leading experts cover such topics as:
The use of severe plastic deformation technique to enhance the properties of nanostructured metals
Descriptions of the different polymers for use in controlled drug release
Chitin and chitosan as renewable healthcare biopolymers for biomedical applications
Innovated devices such as "label-free biochips" and polymer MEMS
Molecular imprinting and nanotechnology
Prussian Blue biosensing applications
The evaluation of different types of biosensors in terms of their cost effectiveness, selectivity, and sensitivity
Stimuli-responsive polypeptide nanocarriers for malignancy therapeutics
The design and development of biomaterials play a significant role in the diagnosis, treatment, and prevention of diseases. When used with highly selective and sensitive biomaterials, cutting-edge biodevices can allow the rapid and accurate diagnosis of disease, creating a platform for research and development, especially in the field of treatment for prognosis and detection of diseases in the early stage. This book emphasizes the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities.
The 15 comprehensive chapters written by leading experts cover such topics as:
The use of severe plastic deformation technique to enhance the properties of nanostructured metals
Descriptions of the different polymers for use in controlled drug release
Chitin and chitosan as renewable healthcare biopolymers for biomedical applications
Innovated devices such as "label-free biochips" and polymer MEMS
Molecular imprinting and nanotechnology
Prussian Blue biosensing applications
The evaluation of different types of biosensors in terms of their cost effectiveness, selectivity, and sensitivity
Stimuli-responsive polypeptide nanocarriers for malignancy therapeutics
Produktdetails
- Produktdetails
- Advanced Materials and Technologies
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 576
- Erscheinungstermin: 28. Juli 2014
- Englisch
- Abmessung: 236mm x 152mm x 33mm
- Gewicht: 666g
- ISBN-13: 9781118773635
- ISBN-10: 1118773632
- Artikelnr.: 41246836
- Advanced Materials and Technologies
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 576
- Erscheinungstermin: 28. Juli 2014
- Englisch
- Abmessung: 236mm x 152mm x 33mm
- Gewicht: 666g
- ISBN-13: 9781118773635
- ISBN-10: 1118773632
- Artikelnr.: 41246836
Ashutosh Tiwari is an Associate Professor at the Biosensors and Bioelectronics Centre, Linköping University, Sweden; Editor-in-Chief, Advanced Materials Letters; Secretary General, International Association of Advanced Materials; a materials chemist and also a docent in applied physics at Linköping University, Sweden. He has published more than 350 articles, patents, and conference proceedings in the field of materials science and technology and has edited/authored more than fifteen books on the advanced state-of-the-art of materials science. He is a founding member of the Advanced Materials World Congress and the Indian Materials Congress. Anis N. Nordin received her D.Sc. in computer engineering from George Washington University in 2008. She is now an Assistant Professor in the Department of Electrical and Computer Engineering at the International Islamic University Malaysia, Kuala Lumpur. Her main research interests are in the areas of biosensors, lab-on-chip devices, Analog VLSI, RF-MEMS, surface acoustic wave resonators, and oscillators in particular. She is currently a visiting scholar at the Biosensors and Bioelectronics Center, Linköping University, Sweden.
Preface xv Part 1: Cutting-edge Biomaterials 1 Frontiers for Bulk
Nanostructured Metals in Biomedical Applications 3 T.C. Lowe and R.Z.
Valiev 1.1 Introduction to Nanostructured Metals 3 1.2 Nanostructured
Metals as Biomaterials for Medical Applications 10 1.3 Summary and
Conclusions 29 Acknowledgment 30 References 30 2 Stimuli-responsive
Materials Used as Medical Devices in Loading and Releasing of Drugs 53 H.
Iván Meléndez-Ortiz and Emilio Bucio 2.1 Introduction 54 2.2 Classification
of Materials for Bioapplications 55 2.3 Responsive Polymers in Controlled
Drug Delivery 56 2.4 Types of Medical Devices 60 2.5 Materials Used in
Medical Devices 62 2.6 Stimuli-responsive Polymers Used in Medical Devices
65 2.7 Infections Associated with Medical Devices 68 Acknowledgements 72
References 73 3 Recent Advances with Liposomes as Drug Carriers 79 Shravan
Kumar Sriraman and Vladimir P. Torchilin 3.1 Introduction 80 3.2 Passive
Targeting of Liposomes 83 3.3 Actively Targeted Liposomes 88 3.4
Multifunctional Liposomes 95 3.5 Conclusions and Future Directions 98
References 101 4 Fabrication, Properties of Nanoshells with Controllable
Surface Charge and its Applications 121 Parul Khurana, Sheenam Thatai and
Dinesh Kumar 4.1 What is Nanotechnology? 122 4.2 Nanomaterials and Their
Uses 122 4.3 Classification of Nanomaterials 124 4.4 Nanoparticles 126 4.5
Nanocomposites Material 128 4.6 Spherical Silica Particles 129 4.7 Silver
Nanoparticles 132 4.8 Gold Nanoparticles 134 4.9 SiO2@Ag and SiO2@Au
Core-shell Nanocomposites 137 4.10 Surface Enhanced Raman Scattering 139
4.11 Conclusions 141 Acknowledgements 141 References 141 5 Chitosan as an
Advanced Healthcare Material 147 M.A. Jardine and S. Sayed 147 5.1
Introduction 147 5.2 Chemical Modification and Analysis 150 5.3 Chitosan
Co-polymers 154 5.4 Nanoparticles 156 5.5 Nanofibres (Electrospinning) 158
5.6 Visualising Nanostructures 160 5.7 Biomedical Applications of Chitosan
163 5.8 Conclusion 175 References 175 6 Chitosan and Low Molecular Weight
Chitosan: Biological and Biomedical Applications 183 Nazma N. Inamdar and
Vishnukant Mourya 6.1 Introduction 184 6.2 Biodegradability of Chitin and
Chitosan 184 6.3 Biocomapatibility and Toxicology of Chitin and Chitosan
186 6.4 Chitosan as Antimicrobial Agent 187 6.5 Chitosan as Haemostatic
Agent 196 6.6 Chitosan as Immunity Modulator 198 6.7 Chitosan as Adjuvant
202 6.8 Chitosan as Wound Healing Accelerator 203 6.9 Chitosan as Lipid
Lowering Agent & Dietary Supplement in Aid of Weight Loss 211 6.10 Chitosan
as Antioxidant 214 6.11 Conclusion 220 References 221 7 Anticipating
Behaviour of Advanced Materials in Healthcare 243 Tanvir Arfin and Simin
Fatma 7.1 Introduction 244 7.2 The Evolution of the Bio-advance Materials
Fields 246 7.3 Evaluation in Humans 247 7.4 The Natural History of Diseases
248 7.5 Enzyme 249 7.6 Biosensor 259 7.7 Platinum Material Used in Medicine
267 7.8 Antibody 268 7.9 Antibody microarrays 275 7.10 Conclusion 278
References 279 Part 2: Innovative Biodevices 289 8 Label-Free Biochips 291
Anis N. Nordin 8.1 Introduction 291 8.2 Label-Free Analysis 292 8.3
Electrochemical Biosensors 293 8.4 Acoustic Wave-based Mass Sensors 297 8.5
Bulk Acoustic Wave Sensors 297 8.6 Surface Acoustic Wave Mass Sensors 300
8.7 Conclusion and Future Prospects 302 References 303 9 Polymer MEMS
Sensors 305 V. Seena, Prasenjithn Ray, Prashanthi Kovur, Manoj Kandpal and
V. Ramgopal Rao 9.1 Introduction 306 9.2 Polymer Nanocomposite
Piezoresistive Microcantilever Sensors 309 9.3 Organic CantiFET 318 9.4
Polymer Microcantilever Sensors with Embedded Al-doped ZnO Transistor 324
9.5 Piezoelectric Nanocomposite (SU-8/ZNO) Thin Films Studies and Their
Integration with Piezoelectric MEMS Devices 327 9.6 Polymer Nanomechanical
Cantilever Sensors for Detection of Explosives 334 References 337 10
Assembly of Polymers/Metal Nanoparticles and their Applications as Medical
Devices 343 Magdalena Stevanovic 10.1 Introduction 344 10.2 Platinum
Nanoparticles 346 10.3 Gold Nanoparticles 347 10.4 Silver Nanoparticles 350
10.5 Assembly of Polymers/Silver Nanoparticles 351 10.6 Conclusion 357
Acknowledgements 357 References 357 11 Combination of Molecular Imprinting
and Nanotechnology: Beginning of a New Horizon 367 Rashmi Madhuri, Ekta
Roy, Kritika Gupta and Prashant K. Sharma 11.1 Introduction 368 11.2
Classification of Imprinted Nanomaterials 374 11.3 Imprinted Materials at
Nanoscale 412 11.4 Conclusions & Future Outlook 418 Acknowledgements 419
References 419 12 Prussian Blue and Analogues: Biosensing Applications in
Health Care 423 Salazar P, Martin M, O'Neill RD, Lorenzo-Luis P, Roche R
and González-Mora JL 12.1 Introduction 424 12.2 General Aspects of Prussian
Blue and Other Hexacyanoferrates 426 12.3 Prussian Blue: Hydrogen Peroxide
Electrocatalysis 428 12.4 Prussian Blue: Biosensor Applications 430 12.5
Prussian Blue: Immunosensor Applications 439 12.6 Conclusions 446
Acknowledgment 446 References 447 13 Efficiency of Biosensors as New
Generation of Analytical Approaches at the Biochemical Diagnostics of
Diseases 451 N.F. Starodub and M. D. Melnychuk 13.1 Introduction 452 13.2
General Approaches for the Development of Optical Immune Biosensors 452
13.3 Electrochemical Enzymatic Biosensors Based on the Ion-sensitive Field
Effect Transistors (ISFETs) 471 13.4 Multi-parametrical Biosensors [49-51]
475 13.5 Modeling Selective Sites and their Application in the Sensory
Technology 478 13.6 Conclusion 481 References 482 14 Nanoparticles: Scope
in Drug Delivery 487 Megha Tanwar, Jaishree Meena and Laxman S. Meena 14.1
Introduction 488 14.2 Different Forms of Nanoparticles as Drug Delivery 489
14.3 Tuberculosis Targeting Nanoparticles 493 14.4 Cancer & Tumor Targeting
Nanoparticles 505 14.5 Conclusion 511 References 512 15 Smart Polypeptide
Nanocarriers for Malignancy Therapeutics 523 Jianxun Ding, Di Li, Xiuli
Zhuang and Xuesi Chen 15.1 Introduction 523 15.2 Smart Polypeptide
Nanovehicles for Antitumor Drug Delivery 525 15.3 Conclusions and
Perspectives 539 References 539 Index 547
Nanostructured Metals in Biomedical Applications 3 T.C. Lowe and R.Z.
Valiev 1.1 Introduction to Nanostructured Metals 3 1.2 Nanostructured
Metals as Biomaterials for Medical Applications 10 1.3 Summary and
Conclusions 29 Acknowledgment 30 References 30 2 Stimuli-responsive
Materials Used as Medical Devices in Loading and Releasing of Drugs 53 H.
Iván Meléndez-Ortiz and Emilio Bucio 2.1 Introduction 54 2.2 Classification
of Materials for Bioapplications 55 2.3 Responsive Polymers in Controlled
Drug Delivery 56 2.4 Types of Medical Devices 60 2.5 Materials Used in
Medical Devices 62 2.6 Stimuli-responsive Polymers Used in Medical Devices
65 2.7 Infections Associated with Medical Devices 68 Acknowledgements 72
References 73 3 Recent Advances with Liposomes as Drug Carriers 79 Shravan
Kumar Sriraman and Vladimir P. Torchilin 3.1 Introduction 80 3.2 Passive
Targeting of Liposomes 83 3.3 Actively Targeted Liposomes 88 3.4
Multifunctional Liposomes 95 3.5 Conclusions and Future Directions 98
References 101 4 Fabrication, Properties of Nanoshells with Controllable
Surface Charge and its Applications 121 Parul Khurana, Sheenam Thatai and
Dinesh Kumar 4.1 What is Nanotechnology? 122 4.2 Nanomaterials and Their
Uses 122 4.3 Classification of Nanomaterials 124 4.4 Nanoparticles 126 4.5
Nanocomposites Material 128 4.6 Spherical Silica Particles 129 4.7 Silver
Nanoparticles 132 4.8 Gold Nanoparticles 134 4.9 SiO2@Ag and SiO2@Au
Core-shell Nanocomposites 137 4.10 Surface Enhanced Raman Scattering 139
4.11 Conclusions 141 Acknowledgements 141 References 141 5 Chitosan as an
Advanced Healthcare Material 147 M.A. Jardine and S. Sayed 147 5.1
Introduction 147 5.2 Chemical Modification and Analysis 150 5.3 Chitosan
Co-polymers 154 5.4 Nanoparticles 156 5.5 Nanofibres (Electrospinning) 158
5.6 Visualising Nanostructures 160 5.7 Biomedical Applications of Chitosan
163 5.8 Conclusion 175 References 175 6 Chitosan and Low Molecular Weight
Chitosan: Biological and Biomedical Applications 183 Nazma N. Inamdar and
Vishnukant Mourya 6.1 Introduction 184 6.2 Biodegradability of Chitin and
Chitosan 184 6.3 Biocomapatibility and Toxicology of Chitin and Chitosan
186 6.4 Chitosan as Antimicrobial Agent 187 6.5 Chitosan as Haemostatic
Agent 196 6.6 Chitosan as Immunity Modulator 198 6.7 Chitosan as Adjuvant
202 6.8 Chitosan as Wound Healing Accelerator 203 6.9 Chitosan as Lipid
Lowering Agent & Dietary Supplement in Aid of Weight Loss 211 6.10 Chitosan
as Antioxidant 214 6.11 Conclusion 220 References 221 7 Anticipating
Behaviour of Advanced Materials in Healthcare 243 Tanvir Arfin and Simin
Fatma 7.1 Introduction 244 7.2 The Evolution of the Bio-advance Materials
Fields 246 7.3 Evaluation in Humans 247 7.4 The Natural History of Diseases
248 7.5 Enzyme 249 7.6 Biosensor 259 7.7 Platinum Material Used in Medicine
267 7.8 Antibody 268 7.9 Antibody microarrays 275 7.10 Conclusion 278
References 279 Part 2: Innovative Biodevices 289 8 Label-Free Biochips 291
Anis N. Nordin 8.1 Introduction 291 8.2 Label-Free Analysis 292 8.3
Electrochemical Biosensors 293 8.4 Acoustic Wave-based Mass Sensors 297 8.5
Bulk Acoustic Wave Sensors 297 8.6 Surface Acoustic Wave Mass Sensors 300
8.7 Conclusion and Future Prospects 302 References 303 9 Polymer MEMS
Sensors 305 V. Seena, Prasenjithn Ray, Prashanthi Kovur, Manoj Kandpal and
V. Ramgopal Rao 9.1 Introduction 306 9.2 Polymer Nanocomposite
Piezoresistive Microcantilever Sensors 309 9.3 Organic CantiFET 318 9.4
Polymer Microcantilever Sensors with Embedded Al-doped ZnO Transistor 324
9.5 Piezoelectric Nanocomposite (SU-8/ZNO) Thin Films Studies and Their
Integration with Piezoelectric MEMS Devices 327 9.6 Polymer Nanomechanical
Cantilever Sensors for Detection of Explosives 334 References 337 10
Assembly of Polymers/Metal Nanoparticles and their Applications as Medical
Devices 343 Magdalena Stevanovic 10.1 Introduction 344 10.2 Platinum
Nanoparticles 346 10.3 Gold Nanoparticles 347 10.4 Silver Nanoparticles 350
10.5 Assembly of Polymers/Silver Nanoparticles 351 10.6 Conclusion 357
Acknowledgements 357 References 357 11 Combination of Molecular Imprinting
and Nanotechnology: Beginning of a New Horizon 367 Rashmi Madhuri, Ekta
Roy, Kritika Gupta and Prashant K. Sharma 11.1 Introduction 368 11.2
Classification of Imprinted Nanomaterials 374 11.3 Imprinted Materials at
Nanoscale 412 11.4 Conclusions & Future Outlook 418 Acknowledgements 419
References 419 12 Prussian Blue and Analogues: Biosensing Applications in
Health Care 423 Salazar P, Martin M, O'Neill RD, Lorenzo-Luis P, Roche R
and González-Mora JL 12.1 Introduction 424 12.2 General Aspects of Prussian
Blue and Other Hexacyanoferrates 426 12.3 Prussian Blue: Hydrogen Peroxide
Electrocatalysis 428 12.4 Prussian Blue: Biosensor Applications 430 12.5
Prussian Blue: Immunosensor Applications 439 12.6 Conclusions 446
Acknowledgment 446 References 447 13 Efficiency of Biosensors as New
Generation of Analytical Approaches at the Biochemical Diagnostics of
Diseases 451 N.F. Starodub and M. D. Melnychuk 13.1 Introduction 452 13.2
General Approaches for the Development of Optical Immune Biosensors 452
13.3 Electrochemical Enzymatic Biosensors Based on the Ion-sensitive Field
Effect Transistors (ISFETs) 471 13.4 Multi-parametrical Biosensors [49-51]
475 13.5 Modeling Selective Sites and their Application in the Sensory
Technology 478 13.6 Conclusion 481 References 482 14 Nanoparticles: Scope
in Drug Delivery 487 Megha Tanwar, Jaishree Meena and Laxman S. Meena 14.1
Introduction 488 14.2 Different Forms of Nanoparticles as Drug Delivery 489
14.3 Tuberculosis Targeting Nanoparticles 493 14.4 Cancer & Tumor Targeting
Nanoparticles 505 14.5 Conclusion 511 References 512 15 Smart Polypeptide
Nanocarriers for Malignancy Therapeutics 523 Jianxun Ding, Di Li, Xiuli
Zhuang and Xuesi Chen 15.1 Introduction 523 15.2 Smart Polypeptide
Nanovehicles for Antitumor Drug Delivery 525 15.3 Conclusions and
Perspectives 539 References 539 Index 547
Preface xv Part 1: Cutting-edge Biomaterials 1 Frontiers for Bulk
Nanostructured Metals in Biomedical Applications 3 T.C. Lowe and R.Z.
Valiev 1.1 Introduction to Nanostructured Metals 3 1.2 Nanostructured
Metals as Biomaterials for Medical Applications 10 1.3 Summary and
Conclusions 29 Acknowledgment 30 References 30 2 Stimuli-responsive
Materials Used as Medical Devices in Loading and Releasing of Drugs 53 H.
Iván Meléndez-Ortiz and Emilio Bucio 2.1 Introduction 54 2.2 Classification
of Materials for Bioapplications 55 2.3 Responsive Polymers in Controlled
Drug Delivery 56 2.4 Types of Medical Devices 60 2.5 Materials Used in
Medical Devices 62 2.6 Stimuli-responsive Polymers Used in Medical Devices
65 2.7 Infections Associated with Medical Devices 68 Acknowledgements 72
References 73 3 Recent Advances with Liposomes as Drug Carriers 79 Shravan
Kumar Sriraman and Vladimir P. Torchilin 3.1 Introduction 80 3.2 Passive
Targeting of Liposomes 83 3.3 Actively Targeted Liposomes 88 3.4
Multifunctional Liposomes 95 3.5 Conclusions and Future Directions 98
References 101 4 Fabrication, Properties of Nanoshells with Controllable
Surface Charge and its Applications 121 Parul Khurana, Sheenam Thatai and
Dinesh Kumar 4.1 What is Nanotechnology? 122 4.2 Nanomaterials and Their
Uses 122 4.3 Classification of Nanomaterials 124 4.4 Nanoparticles 126 4.5
Nanocomposites Material 128 4.6 Spherical Silica Particles 129 4.7 Silver
Nanoparticles 132 4.8 Gold Nanoparticles 134 4.9 SiO2@Ag and SiO2@Au
Core-shell Nanocomposites 137 4.10 Surface Enhanced Raman Scattering 139
4.11 Conclusions 141 Acknowledgements 141 References 141 5 Chitosan as an
Advanced Healthcare Material 147 M.A. Jardine and S. Sayed 147 5.1
Introduction 147 5.2 Chemical Modification and Analysis 150 5.3 Chitosan
Co-polymers 154 5.4 Nanoparticles 156 5.5 Nanofibres (Electrospinning) 158
5.6 Visualising Nanostructures 160 5.7 Biomedical Applications of Chitosan
163 5.8 Conclusion 175 References 175 6 Chitosan and Low Molecular Weight
Chitosan: Biological and Biomedical Applications 183 Nazma N. Inamdar and
Vishnukant Mourya 6.1 Introduction 184 6.2 Biodegradability of Chitin and
Chitosan 184 6.3 Biocomapatibility and Toxicology of Chitin and Chitosan
186 6.4 Chitosan as Antimicrobial Agent 187 6.5 Chitosan as Haemostatic
Agent 196 6.6 Chitosan as Immunity Modulator 198 6.7 Chitosan as Adjuvant
202 6.8 Chitosan as Wound Healing Accelerator 203 6.9 Chitosan as Lipid
Lowering Agent & Dietary Supplement in Aid of Weight Loss 211 6.10 Chitosan
as Antioxidant 214 6.11 Conclusion 220 References 221 7 Anticipating
Behaviour of Advanced Materials in Healthcare 243 Tanvir Arfin and Simin
Fatma 7.1 Introduction 244 7.2 The Evolution of the Bio-advance Materials
Fields 246 7.3 Evaluation in Humans 247 7.4 The Natural History of Diseases
248 7.5 Enzyme 249 7.6 Biosensor 259 7.7 Platinum Material Used in Medicine
267 7.8 Antibody 268 7.9 Antibody microarrays 275 7.10 Conclusion 278
References 279 Part 2: Innovative Biodevices 289 8 Label-Free Biochips 291
Anis N. Nordin 8.1 Introduction 291 8.2 Label-Free Analysis 292 8.3
Electrochemical Biosensors 293 8.4 Acoustic Wave-based Mass Sensors 297 8.5
Bulk Acoustic Wave Sensors 297 8.6 Surface Acoustic Wave Mass Sensors 300
8.7 Conclusion and Future Prospects 302 References 303 9 Polymer MEMS
Sensors 305 V. Seena, Prasenjithn Ray, Prashanthi Kovur, Manoj Kandpal and
V. Ramgopal Rao 9.1 Introduction 306 9.2 Polymer Nanocomposite
Piezoresistive Microcantilever Sensors 309 9.3 Organic CantiFET 318 9.4
Polymer Microcantilever Sensors with Embedded Al-doped ZnO Transistor 324
9.5 Piezoelectric Nanocomposite (SU-8/ZNO) Thin Films Studies and Their
Integration with Piezoelectric MEMS Devices 327 9.6 Polymer Nanomechanical
Cantilever Sensors for Detection of Explosives 334 References 337 10
Assembly of Polymers/Metal Nanoparticles and their Applications as Medical
Devices 343 Magdalena Stevanovic 10.1 Introduction 344 10.2 Platinum
Nanoparticles 346 10.3 Gold Nanoparticles 347 10.4 Silver Nanoparticles 350
10.5 Assembly of Polymers/Silver Nanoparticles 351 10.6 Conclusion 357
Acknowledgements 357 References 357 11 Combination of Molecular Imprinting
and Nanotechnology: Beginning of a New Horizon 367 Rashmi Madhuri, Ekta
Roy, Kritika Gupta and Prashant K. Sharma 11.1 Introduction 368 11.2
Classification of Imprinted Nanomaterials 374 11.3 Imprinted Materials at
Nanoscale 412 11.4 Conclusions & Future Outlook 418 Acknowledgements 419
References 419 12 Prussian Blue and Analogues: Biosensing Applications in
Health Care 423 Salazar P, Martin M, O'Neill RD, Lorenzo-Luis P, Roche R
and González-Mora JL 12.1 Introduction 424 12.2 General Aspects of Prussian
Blue and Other Hexacyanoferrates 426 12.3 Prussian Blue: Hydrogen Peroxide
Electrocatalysis 428 12.4 Prussian Blue: Biosensor Applications 430 12.5
Prussian Blue: Immunosensor Applications 439 12.6 Conclusions 446
Acknowledgment 446 References 447 13 Efficiency of Biosensors as New
Generation of Analytical Approaches at the Biochemical Diagnostics of
Diseases 451 N.F. Starodub and M. D. Melnychuk 13.1 Introduction 452 13.2
General Approaches for the Development of Optical Immune Biosensors 452
13.3 Electrochemical Enzymatic Biosensors Based on the Ion-sensitive Field
Effect Transistors (ISFETs) 471 13.4 Multi-parametrical Biosensors [49-51]
475 13.5 Modeling Selective Sites and their Application in the Sensory
Technology 478 13.6 Conclusion 481 References 482 14 Nanoparticles: Scope
in Drug Delivery 487 Megha Tanwar, Jaishree Meena and Laxman S. Meena 14.1
Introduction 488 14.2 Different Forms of Nanoparticles as Drug Delivery 489
14.3 Tuberculosis Targeting Nanoparticles 493 14.4 Cancer & Tumor Targeting
Nanoparticles 505 14.5 Conclusion 511 References 512 15 Smart Polypeptide
Nanocarriers for Malignancy Therapeutics 523 Jianxun Ding, Di Li, Xiuli
Zhuang and Xuesi Chen 15.1 Introduction 523 15.2 Smart Polypeptide
Nanovehicles for Antitumor Drug Delivery 525 15.3 Conclusions and
Perspectives 539 References 539 Index 547
Nanostructured Metals in Biomedical Applications 3 T.C. Lowe and R.Z.
Valiev 1.1 Introduction to Nanostructured Metals 3 1.2 Nanostructured
Metals as Biomaterials for Medical Applications 10 1.3 Summary and
Conclusions 29 Acknowledgment 30 References 30 2 Stimuli-responsive
Materials Used as Medical Devices in Loading and Releasing of Drugs 53 H.
Iván Meléndez-Ortiz and Emilio Bucio 2.1 Introduction 54 2.2 Classification
of Materials for Bioapplications 55 2.3 Responsive Polymers in Controlled
Drug Delivery 56 2.4 Types of Medical Devices 60 2.5 Materials Used in
Medical Devices 62 2.6 Stimuli-responsive Polymers Used in Medical Devices
65 2.7 Infections Associated with Medical Devices 68 Acknowledgements 72
References 73 3 Recent Advances with Liposomes as Drug Carriers 79 Shravan
Kumar Sriraman and Vladimir P. Torchilin 3.1 Introduction 80 3.2 Passive
Targeting of Liposomes 83 3.3 Actively Targeted Liposomes 88 3.4
Multifunctional Liposomes 95 3.5 Conclusions and Future Directions 98
References 101 4 Fabrication, Properties of Nanoshells with Controllable
Surface Charge and its Applications 121 Parul Khurana, Sheenam Thatai and
Dinesh Kumar 4.1 What is Nanotechnology? 122 4.2 Nanomaterials and Their
Uses 122 4.3 Classification of Nanomaterials 124 4.4 Nanoparticles 126 4.5
Nanocomposites Material 128 4.6 Spherical Silica Particles 129 4.7 Silver
Nanoparticles 132 4.8 Gold Nanoparticles 134 4.9 SiO2@Ag and SiO2@Au
Core-shell Nanocomposites 137 4.10 Surface Enhanced Raman Scattering 139
4.11 Conclusions 141 Acknowledgements 141 References 141 5 Chitosan as an
Advanced Healthcare Material 147 M.A. Jardine and S. Sayed 147 5.1
Introduction 147 5.2 Chemical Modification and Analysis 150 5.3 Chitosan
Co-polymers 154 5.4 Nanoparticles 156 5.5 Nanofibres (Electrospinning) 158
5.6 Visualising Nanostructures 160 5.7 Biomedical Applications of Chitosan
163 5.8 Conclusion 175 References 175 6 Chitosan and Low Molecular Weight
Chitosan: Biological and Biomedical Applications 183 Nazma N. Inamdar and
Vishnukant Mourya 6.1 Introduction 184 6.2 Biodegradability of Chitin and
Chitosan 184 6.3 Biocomapatibility and Toxicology of Chitin and Chitosan
186 6.4 Chitosan as Antimicrobial Agent 187 6.5 Chitosan as Haemostatic
Agent 196 6.6 Chitosan as Immunity Modulator 198 6.7 Chitosan as Adjuvant
202 6.8 Chitosan as Wound Healing Accelerator 203 6.9 Chitosan as Lipid
Lowering Agent & Dietary Supplement in Aid of Weight Loss 211 6.10 Chitosan
as Antioxidant 214 6.11 Conclusion 220 References 221 7 Anticipating
Behaviour of Advanced Materials in Healthcare 243 Tanvir Arfin and Simin
Fatma 7.1 Introduction 244 7.2 The Evolution of the Bio-advance Materials
Fields 246 7.3 Evaluation in Humans 247 7.4 The Natural History of Diseases
248 7.5 Enzyme 249 7.6 Biosensor 259 7.7 Platinum Material Used in Medicine
267 7.8 Antibody 268 7.9 Antibody microarrays 275 7.10 Conclusion 278
References 279 Part 2: Innovative Biodevices 289 8 Label-Free Biochips 291
Anis N. Nordin 8.1 Introduction 291 8.2 Label-Free Analysis 292 8.3
Electrochemical Biosensors 293 8.4 Acoustic Wave-based Mass Sensors 297 8.5
Bulk Acoustic Wave Sensors 297 8.6 Surface Acoustic Wave Mass Sensors 300
8.7 Conclusion and Future Prospects 302 References 303 9 Polymer MEMS
Sensors 305 V. Seena, Prasenjithn Ray, Prashanthi Kovur, Manoj Kandpal and
V. Ramgopal Rao 9.1 Introduction 306 9.2 Polymer Nanocomposite
Piezoresistive Microcantilever Sensors 309 9.3 Organic CantiFET 318 9.4
Polymer Microcantilever Sensors with Embedded Al-doped ZnO Transistor 324
9.5 Piezoelectric Nanocomposite (SU-8/ZNO) Thin Films Studies and Their
Integration with Piezoelectric MEMS Devices 327 9.6 Polymer Nanomechanical
Cantilever Sensors for Detection of Explosives 334 References 337 10
Assembly of Polymers/Metal Nanoparticles and their Applications as Medical
Devices 343 Magdalena Stevanovic 10.1 Introduction 344 10.2 Platinum
Nanoparticles 346 10.3 Gold Nanoparticles 347 10.4 Silver Nanoparticles 350
10.5 Assembly of Polymers/Silver Nanoparticles 351 10.6 Conclusion 357
Acknowledgements 357 References 357 11 Combination of Molecular Imprinting
and Nanotechnology: Beginning of a New Horizon 367 Rashmi Madhuri, Ekta
Roy, Kritika Gupta and Prashant K. Sharma 11.1 Introduction 368 11.2
Classification of Imprinted Nanomaterials 374 11.3 Imprinted Materials at
Nanoscale 412 11.4 Conclusions & Future Outlook 418 Acknowledgements 419
References 419 12 Prussian Blue and Analogues: Biosensing Applications in
Health Care 423 Salazar P, Martin M, O'Neill RD, Lorenzo-Luis P, Roche R
and González-Mora JL 12.1 Introduction 424 12.2 General Aspects of Prussian
Blue and Other Hexacyanoferrates 426 12.3 Prussian Blue: Hydrogen Peroxide
Electrocatalysis 428 12.4 Prussian Blue: Biosensor Applications 430 12.5
Prussian Blue: Immunosensor Applications 439 12.6 Conclusions 446
Acknowledgment 446 References 447 13 Efficiency of Biosensors as New
Generation of Analytical Approaches at the Biochemical Diagnostics of
Diseases 451 N.F. Starodub and M. D. Melnychuk 13.1 Introduction 452 13.2
General Approaches for the Development of Optical Immune Biosensors 452
13.3 Electrochemical Enzymatic Biosensors Based on the Ion-sensitive Field
Effect Transistors (ISFETs) 471 13.4 Multi-parametrical Biosensors [49-51]
475 13.5 Modeling Selective Sites and their Application in the Sensory
Technology 478 13.6 Conclusion 481 References 482 14 Nanoparticles: Scope
in Drug Delivery 487 Megha Tanwar, Jaishree Meena and Laxman S. Meena 14.1
Introduction 488 14.2 Different Forms of Nanoparticles as Drug Delivery 489
14.3 Tuberculosis Targeting Nanoparticles 493 14.4 Cancer & Tumor Targeting
Nanoparticles 505 14.5 Conclusion 511 References 512 15 Smart Polypeptide
Nanocarriers for Malignancy Therapeutics 523 Jianxun Ding, Di Li, Xiuli
Zhuang and Xuesi Chen 15.1 Introduction 523 15.2 Smart Polypeptide
Nanovehicles for Antitumor Drug Delivery 525 15.3 Conclusions and
Perspectives 539 References 539 Index 547
"Overall, this is a fascinating series of diverse chapters, with a large range of quality in the presentation and diagram quality, and the reader has to have an extensive knowledge of biochemistry and nanotechnology to really appreciate the cutting edge technology presented in this book." (Scope, 1 February 2014)