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In the past three decades, interventional cardiology has grown tremendously due to development of new devices and expansion of indications based on clinical trials. This issue of Cardiology Clinics provides an updated view of advanced techniques in the rapidly changing and growing field of interventional cardiology. The articles included discuss important topics such as emerging techniques for vulnerable plaque detection, coronary bifurcation lesions, drug eluting stents, and left ventricular assist devices.