An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.
Inhaltsangabe
Chapter 1 Introduction Denson G. Fujikawa
General considerations
Chapter 2 Excitotoxic programmed cell death involves caspase-independent mechanisms Ted M. Dawson and Valina L. Dawson
Chapter 3 To survive or to die: how neurons deal with it Yubin Wang, Xiaoning Bi and Michel Baudry
Traumatic Brain Injury
Chapter 4 Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches Edward D. Hall, Indrapal N. Singh and John E. Cebak
Chapter 5 Mitochondrial damage in traumatic CNS injury W. Brad Hubbard, Laurie M. Davis and Patrick G. Sullivan
Chapter 6 Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury Lu-Yang Tao
Focal Cerebral Ischemia
Chapter 7 Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia Nikolaus Plesnila and Carsten Culmsee
Transient global cerebral ischemia
Chapter 8 Apoptosis-inducing factor translocation to nuclei after transient global ischemia Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen and Feng Zhang
Chapter 9 Necroptosis in cerebral ischemia Marta Vieira and Ana Luisa Carvalho
Chapter 10 Histological and elemental changes in ischemic stroke M. Jake Pushie, Vedashree Meher, Nicole Sylvain, Huishu Hou, Annalise Kudryk, Michael B. Kelly and Roland N. Auer
Hypoglycemic neuronal injury
Chapter 11 Hypoglycemic brain damage Roland N. Auer
Seizure-induced neuronal death
Chapter 12 Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis Denson G. Fujikawa
Chapter 2 Excitotoxic programmed cell death involves caspase-independent mechanisms Ted M. Dawson and Valina L. Dawson
Chapter 3 To survive or to die: how neurons deal with it Yubin Wang, Xiaoning Bi and Michel Baudry
Traumatic Brain Injury
Chapter 4 Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches Edward D. Hall, Indrapal N. Singh and John E. Cebak
Chapter 5 Mitochondrial damage in traumatic CNS injury W. Brad Hubbard, Laurie M. Davis and Patrick G. Sullivan
Chapter 6 Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury Lu-Yang Tao
Focal Cerebral Ischemia
Chapter 7 Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia Nikolaus Plesnila and Carsten Culmsee
Transient global cerebral ischemia
Chapter 8 Apoptosis-inducing factor translocation to nuclei after transient global ischemia Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen and Feng Zhang
Chapter 9 Necroptosis in cerebral ischemia Marta Vieira and Ana Luisa Carvalho
Chapter 10 Histological and elemental changes in ischemic stroke M. Jake Pushie, Vedashree Meher, Nicole Sylvain, Huishu Hou, Annalise Kudryk, Michael B. Kelly and Roland N. Auer
Hypoglycemic neuronal injury
Chapter 11 Hypoglycemic brain damage Roland N. Auer
Seizure-induced neuronal death
Chapter 12 Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis Denson G. Fujikawa
Concluding Remarks Denson G. Fujikawa
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