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In literature are reported various use of activated charcoal and derivates in biopharmaceutical purifications.Aim of this work is to verify impurity profile when using this technology.Various commercial product are reported here but it is not the scope of this work put in relation with any toxicological reaction : only to describe the technique used in this field.Because various drugs and bioproduct need purification steps it if of interest to see some material science peculiarity.Are involved not only innovative vaccine but also protein and mabs and other drugs.In this work various material science concepts are useful to better understand some impurity situations.