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The genus Bordetella contains several pathogenic species generally associated with upper respiratory tract infections in warm-blooded animals. Bordetella pertussis is the etiologic agent of whooping cough. Whooping cough is presently one of the ten most common causes of death from infectious diseases and reported by the World Health Organisation (WHO) to cause 50 million cases and 350000 deaths worldwide per year. The term proteome, in analogy to the term genome, was coined to describe the complete set of proteins that an organism has produced under a defined set of conditions. Proteomics has…mehr

Produktbeschreibung
The genus Bordetella contains several pathogenic
species generally associated with upper respiratory
tract infections in warm-blooded animals. Bordetella
pertussis is the etiologic agent of whooping cough.
Whooping cough is presently one of the ten most
common causes of death from infectious diseases and
reported by the World Health Organisation (WHO) to
cause 50 million cases and 350000 deaths worldwide
per year.
The term proteome, in analogy to the term genome, was
coined to describe the complete set of proteins that
an organism has produced under a defined set of
conditions. Proteomics has been used to identify
novel bacterial vaccine candidates against several
human pathogens. Much of information about
immunogenic component can be derived from proteomics
coupled to Western blotting, namely immunoproteomics.

In the present study, we report first
immunoproteomics analysis to identify candidate
antigens of B. pertussis for vaccine development.
Different sera from mice, which were immunized or
challenged with B. pertussis, were analyzed for
reactivity by Western blot against whole cell
extracts of B. pertussis Tohama and Saadet strains
separated by 2-DE.
Autorenporträt
A better system for humankind is possible,so I have chosen the
way of science to live.Vaccinology and Proteomics are the areas
that I am interested in.I got my BSc degree at Bioengineering
Department of Ege University (2004) and had my MSc degree in
Department of Biotechnology of METU (2007).I have been doing my
PhD in Bologna University (2008-..)