Provides a comprehensive overview of the complex systems approach to epilepsy and explores this theory across multiple scales from genes to the whole brain. Emphasizes therapeutic opportunities that arise from complex systems thinking that can benefit the thirty percent of patients who do not respond to current treatments.
Provides a comprehensive overview of the complex systems approach to epilepsy and explores this theory across multiple scales from genes to the whole brain. Emphasizes therapeutic opportunities that arise from complex systems thinking that can benefit the thirty percent of patients who do not respond to current treatments.
1. Overview Rod Scott and Matt Mahoney; 2. Systems biological approaches to the genetic complexity of the epilepsies Jeffrey L. Brabec, Montana Kay Lara, Anna L. Tyler and J. Matthew Mahoney; 3. Transcriptomic and epigenomic approaches for epilepsy Anika Bongaarts, Jagoda Glowacka, Konrad Wojdan, Angelika Mühlebner, Eleonora Aronica and James D. Mills; 4. Phenomenological mesoscopic models for seizure activity Maria Luisa Saggio and Viktor K. Jirsa; 5. Computational modeling approaches to epilepsy Yujiang Wang, Gabrielle Marie Schroeder, Nishant Sinha and Peter Taylor; 6. The baseline and epileptiform EEG: a complex systems approach Giridhar P. Kalamangalam and Mircea Chelaru; 7. Neuronal approaches to epilepsy Rod Scott and Matt Mahoney; 8. Mapping epileptic networks with scalp and invasive EEG: applications to epileptogenic zone localization and seizure prediction Manel Vila-Vidal and Adria Tauste Campos; 9. A neuroimaging network-level approach to drug-resistant epilepsy Niels A. Foit, Fatemeh Fadaie, Andrea Bernasconi and Neda Bernasconi; 10. Epilepsy as a complex network disorder: insights from functional MRI David Carmichael, Rory J. Piper and Fraser Aitken.
1. Overview Rod Scott and Matt Mahoney; 2. Systems biological approaches to the genetic complexity of the epilepsies Jeffrey L. Brabec, Montana Kay Lara, Anna L. Tyler and J. Matthew Mahoney; 3. Transcriptomic and epigenomic approaches for epilepsy Anika Bongaarts, Jagoda Glowacka, Konrad Wojdan, Angelika Mühlebner, Eleonora Aronica and James D. Mills; 4. Phenomenological mesoscopic models for seizure activity Maria Luisa Saggio and Viktor K. Jirsa; 5. Computational modeling approaches to epilepsy Yujiang Wang, Gabrielle Marie Schroeder, Nishant Sinha and Peter Taylor; 6. The baseline and epileptiform EEG: a complex systems approach Giridhar P. Kalamangalam and Mircea Chelaru; 7. Neuronal approaches to epilepsy Rod Scott and Matt Mahoney; 8. Mapping epileptic networks with scalp and invasive EEG: applications to epileptogenic zone localization and seizure prediction Manel Vila-Vidal and Adria Tauste Campos; 9. A neuroimaging network-level approach to drug-resistant epilepsy Niels A. Foit, Fatemeh Fadaie, Andrea Bernasconi and Neda Bernasconi; 10. Epilepsy as a complex network disorder: insights from functional MRI David Carmichael, Rory J. Piper and Fraser Aitken.
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