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On May 24-26, 2023, the Nobel Prize Summit entitled Truth, Trust, and Hope was convened as a hybrid event to examine misinformation and disinformation in the context of the broader information ecosystem, looking at the global impact of information technologies in nature and society. The summit brought together Nobel laureates, leading scientists, business leaders, writers, artists, and young innovators to share insights, challenges, and solutions relating to trust and information. With a positive narrative and the accelerating prevalence of artificial intelligence, big data, and other emerging information technologies, the summit explored the challenges and opportunities of democratization of knowledge and information and the erosion of trust. Held in Washington, DC and virtually, the 3-day summit attracted more than 700 in-person attendees and more than 10,000 online participants from more than 70 countries. Eleven Nobel laureates were actively engaged in the summit, and 32 partner organizations were involved, including breakout sessions and solution sessions. This publication summarizes the presentations, activities, and discussion of the summit.