Bone Morphogenetic Proteins: From Local to Systemic Therapeutics - Vukicevic, Slobodan / Sampath, Kuber T. (eds.)
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Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. The authors are all recognized experts in the field of tissue engineering and regeneration. …mehr

Produktbeschreibung
Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. The authors are all recognized experts in the field of tissue engineering and regeneration.
  • Produktdetails
  • Progress in Inflammation Research
  • Verlag: Birkhäuser Basel / Springer, Basel
  • Artikelnr. des Verlages: 12085415
  • Erscheinungstermin: 15. Mai 2008
  • Englisch
  • Abmessung: 241mm x 170mm x 24mm
  • Gewicht: 786g
  • ISBN-13: 9783764385514
  • ISBN-10: 3764385510
  • Artikelnr.: 22926893
Autorenporträt
Slobodan Vukicevic, University of Zagreb, Zagreb, Croatia / Kuber T. Sampath, Genzyme Corporation, Framingham, USA
Inhaltsangabe
Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results.- Use of recombinant human BMP-2 in orthopedic trauma.- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects.- Clinical outcomes using rhBMP-2 in spinal fusion applications.- Bone morphogenetic protein signaling is fine-tuned on multiple levels.- Dissection of bone morphogenetic protein signaling using genome-engineering tools.- Alterations of BMP signaling pathway(s) in skeletal diseases.- Signaling cross-talk by bone morphogenetic proteins.- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development.- The role of bone morphogenetic protein 4 (BMP-4) in tooth development.- Bone morphogenetic protein antagonists and kidney.- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins.- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation.- Bone morphogenetic proteins in cartilage biology.- Systemic administration of bone morphogenetic proteins.