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Until recently innate immunity was viewed as the poorer relative of the sophisticated adaptive immune response. We now know, however, that these 'higher' immune responses are actually underpinned by an elegantly hewn system of innate immune surveillance. Discovered first by developmental biologists, again by immunologists, and even by sociologists, Toll receptors have revolutionized our understanding of innate immunology. Although a small part of a complex system, Toll receptor biology compels us to revisit existing models of self - non-self recognition. TOC:Introduction.- Toll Receptors and…mehr

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Produktbeschreibung
Until recently innate immunity was viewed as the poorer relative of the sophisticated adaptive immune response. We now know, however, that these 'higher' immune responses are actually underpinned by an elegantly hewn system of innate immune surveillance. Discovered first by developmental biologists, again by immunologists, and even by sociologists, Toll receptors have revolutionized our understanding of innate immunology. Although a small part of a complex system, Toll receptor biology compels us to revisit existing models of self - non-self recognition. TOC:Introduction.- Toll Receptors and the Renaissance of Innate Immunity.- The Function of Toll-Like Receptors.- Structures and Motifs Involved in Toll Signaling.- "Supramolecular" Activation Custers in Innate Immunity.- Interleukin-1 Receptor/Toll-Like Receptor Signaling.- Virus Induced Signaling to Initiate the Interferon Mediated Anti Viral Host Response.- The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling.- Pathogen Avoidance Using Toll Signaling in C. Elegans.- Forward Genetic Analysis of TLR Pathways: A Shared System for the Detection of Endotoxin and Viral Infection.- Agonists of Toll-Like Receptor 9: Modulation of Host Immune Responses with Synthetic Oligodeoxynucleotides.- Index.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 11.03.2007
  • Englisch
  • ISBN-13: 9780387274454
  • Artikelnr.: 37287250
Autorenporträt
Tina Rich, University of Cambridge, UK
Inhaltsangabe
Introduction Toll Receptors and the Renaissance of Innate Immunity ....................... 1 Beginnings ............................................................................................ 2 The Innate and Adaptive Immune Systems ........................................... 2 Saturation Screening of the Drosophila Genome .................................... 3 The Toll Receptor in Development ....................................................... 4 The Implication of Toll in Fly Immunity .............................................. 5 A Problem with Vaccination.................................................................. 6 The Question of Escape Mutants .......................................................... 7 The Evolution of Toll Receptors ........................................................... 8 To the Clinic ....................................................................................... 14 1. The Function of Toll-Like Receptors ................................................... 18 Developmental Functions .................................................................... 19 The Role in Defense ............................................................................ 22 Divisions of Immunity ........................................................................ 27 Expression and Function of TLRs in Cells of Autonomous Immunity ............................................................... 30 Expression and Function of TLRs in Cells of Central Immunity ......... 33 The Roles of TLRs in APC-T Cell Interactions ................................ 39 TLRs and Theories about the Function of the Immune System ........... 44 TLRs in Health and Disease ................................................................ 51 2. Structures andMotifs Involved in Toll Signaling ................................. 56 Components of the Extracellular Pathway: The Extracellular Leucine-Rich Repeat Domain of TLRs ................ 56 Structural Diversity of TLR Ligands .................................................... 61 Mechanism of Ligand Binding and Signal Transduction ..................... 70 Pathogen Recognition by TLRs ........................................................... 70 Mechanism of Signal Transduction ..................................................... 74 Components of the Intracellular Pathway ............................................ 75 3. 'Supramolecular' Activation Custers in Innate Immunity ................... 94 Lipopolysaccharide Recognition .......................................................... 95 Structure of LPS .................................................................................. 95 The Search for the LPS 'Signal Transducer' ....................................... 96 Microdomains ................................................................................... 101 4. Interleukin-1 Receptor/Toll-Like Receptor Signaling ......................... 110 The 'Hardware' of IL-1R/TLR Signaling ......................................... 110 The NF-êB Family of Transcription Factors ..................................... 115 IL-1R Signaling ................................................................................. 115 Mechanisms of TLR Signaling .......................................................... 118 Termination of IL-1R/TLR Signaling ............................................... 120 The Toll Pathway in Drosophila Melanogaster .................................... 122 TLR-Mediated Apoptosis .................................................................. 124 5. Virus