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Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on…mehr

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Produktbeschreibung
Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing. TOC:History and Morphology of the Lysosome.- Transport of Lysosomal Enzymes.- Adaptor Proteins in Lysosomal Biogenesis.- Lysosomal Storage Disorders.- Lysosomal Proteases: Revival of the Sleeping Beauty.- Lysosomal Membrane Proteins.- Lysosomal Transporters.- Neuronal Ceroid Lipofuscinosis (NCL).- Cholesterol Transport in Lysosomes.- Therapy of Lysosomal Storage Diseases.- Lysosomal Proteome and Transcriptome.- External Lysosomes.- Repair of Plasma Membrane by Lysosome Fusion.- Macroautophagy.- Chaperone-Mediated Autophagy.

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 20.03.2007
  • Englisch
  • ISBN-13: 9780387289571
  • Artikelnr.: 37287468
Autorenporträt
Paul Saftig, Biochemisches Institut, Kiel, Germany
Inhaltsangabe
History and Morphology of the Lysosome.- Transport of Lysosomal Enzymes.- Adaptor Proteins in Lysosomal Biogenesis.- Lysosomal Membrane Proteins.- Lysosomal Proteases.- Lysosomal Storage Disorders.- Lysosomal Transporters and Associated Diseases.- Neuronal Ceroid-Lipofuscinoses.- Cholesterol Transport in Lysosomes.- Therapy of Lysosomal Storage Diseases.- Lysosomal Proteome and Transcriptome.- External Lysosomes.- Membrane Resealing Mediated by Lysosomal Exocytosis.- Macroautophagy in Mammalian Cells.- Chaperone-Mediated Autophagy.