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Recent advances in molecular and biophysical techniques,particularly fluorescence and live cell imaging, arerevolutionizing the study of cell motility. New bioprobes not onlyreveal simple intracellular localization, but also contain detailsof post-translational modifications, conformational state andprotein-protein interactions. Coupling these insights withcomplementary advances in genetic and biochemical methods isenabling scientists to understand the processes involved in cellmotility - from molecular motors to cell movements in vivo in arange of organisms and cell types. This book features…mehr

Produktbeschreibung
Recent advances in molecular and biophysical techniques,particularly fluorescence and live cell imaging, arerevolutionizing the study of cell motility. New bioprobes not onlyreveal simple intracellular localization, but also contain detailsof post-translational modifications, conformational state andprotein-protein interactions. Coupling these insights withcomplementary advances in genetic and biochemical methods isenabling scientists to understand the processes involved in cellmotility - from molecular motors to cell movements in vivo in arange of organisms and cell types. This book features landmark essays that provide an up to date andfascinating account of current research and concepts in cellmotility.These cover the roles of molecular motors that drivemovement and their interactions with the cytoskeleton as well asmembrane dynamics that allow cells to change shape and tomove. Cell motility plays a key role in development - there are chapterson the genetics of cell migration, the regulation of contactrepulsion in growth cones, and the progression from cell migrationto cell-cell adhesion. Cell motility is directional - expertsdescribe the molecules that regulate chemotaxis, allowing cells tomigrate along pathways specified by chemical gradients. Finally,cell motility can be perturbed by mutation--metastasis occurs whencells lose their normal intercellular interactions and invade othertissue types. All these processes are regulated by signals from theenvironment, including other tissues in the body, and the variousmolecules that transmit and transduce these signals arediscussed. This book is a 'must read' for cell biologists working in a varietyof fields, from development to wound healing, at all levels -post-doctoral fellows, post-graduate students and lab technicians.It is also stimulating reading for molecular and developmentalbiologists, biophysicists and biochemists.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 364
  • Erscheinungstermin: 11.04.2005
  • Englisch
  • ISBN-13: 9780470094099
  • Artikelnr.: 37290372
Rezensionen
"...very well written and referenced, and many chapters contain excellent figures...this excellent volume will be a very useful reference for several years to come." ( The Quarterly Review of Biology , December 2004)
"...remarkably up to date...should prove an invaluable resource..." (Nature Cell Biology , August 2004)