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The genetic code is dynamic - it, or its readout, can be specifically changed by mRNA signals that modify the behavior of on-board ribosomes. Many viruses use recoding to maximize utilization of information in small genomes, and probably all organisms use recoding in at least some genes for expanding the regulatory repertoire. The volume will detail specific recoding examples to understand the mechanisms and the mRNA signals. It will continue to detail the biochemical and genetic approaches to identify and study the cellular factors involved in recoding. The signals in mRNA that dictate…mehr

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Produktbeschreibung
The genetic code is dynamic - it, or its readout, can be specifically changed by mRNA signals that modify the behavior of on-board ribosomes. Many viruses use recoding to maximize utilization of information in small genomes, and probably all organisms use recoding in at least some genes for expanding the regulatory repertoire. The volume will detail specific recoding examples to understand the mechanisms and the mRNA signals. It will continue to detail the biochemical and genetic approaches to identify and study the cellular factors involved in recoding. The signals in mRNA that dictate recoding often include complex folded structures of the RNA, which we are studying by a combination of microbiology, genetics, biochemical and NMR approaches.

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 10.03.2010
  • Englisch
  • ISBN-13: 9780387893822
  • Artikelnr.: 37289143
Inhaltsangabe
Table of Contents Foreword Marshall Nirenberg Preface John F. Atkins, Raymond F. Gesteland Selenocysteine Biosynthesis, Selenoproteins and Selenoproteomes Vadim N. Gladyshev, Dolph L. Hatfield Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factors Marla J. Berry, Michael T. Howard Translation of UAG as pyrrolysine Joseph A. Krzycki Specification of standard amino acids by stop codons Olivier Namy, Jean-Pierre Rousset Ribosome 'Skipping': 'Stop-Carry On' or 'StopGo' Translation Jeremy D. Brown, Martin D. Ryan Recoding Therapies for Genetic Diseases Kim M. Keeling, David M. Bedwell Pseudoknot-dependent Programmed -1 Ribosomal Frameshifting: Structures, Mechanisms and Models Ian Brierley, Robert J. C. Gilbert, Simon Pennell Programmed -1 ribosomal frameshift in the human immunodeficiency virus of type 1 Léa Brakier-Gingras, Dominic Dulude Ribosomal frameshifting in decoding plant viral RNAs W. Allen Miller, David P. Giedroc Programmed frameshifting in budding yeast Philip J. Farabaugh Recoding in bacteriophages Roger W. Hendrix Programmed Ribosomal -1 Frameshifting as a Tradition: the Bacterial Transposable Elements of the IS3 Family Olivier Fayet, Marie-Françoise Prère Autoregulatory frameshifting in antizyme gene expression governs polyamine levels from yeast to mammals Ivaylo P. Ivanov, Senya Matsufuji Sequences promoting Recoding are Singular Genomic Elements Pavel V.Baranov, Olga Gurvich Mutants that affect recoding Jonathon D. Dinman, Michael O'Connor The E site and its importance for improving accuracy and preventing frameshifts Markus Pech, Oliver Vesper, Hiroshi Yamamoto, Daniel N. Wilson, Knud H. Nierhaus Translational Bypassing - peptidyl-tRNA re-paring at non-overlapping sites Norma M. Wills trans-Translation Kenneth Keiler, Dennis M. Lee Transcript slippage and recoding Michael Anikin, Vadim Molodtsov, Dmitry Temiakov, William T. McAllister Computational resources for studying recoding Andrew E. Firth, Michaël Bekaert, Pavel V. Baranov Appendix