Cancer Risk Assessment (eBook, PDF)
Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification
Redaktion: Hsu, Ching-Hung; Stedeford, Todd
Cancer Risk Assessment (eBook, PDF)
Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification
Redaktion: Hsu, Ching-Hung; Stedeford, Todd
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With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.…mehr
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- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 856
- Erscheinungstermin: 21. Juni 2010
- Englisch
- ISBN-13: 9780470622711
- Artikelnr.: 37298053
- Verlag: John Wiley & Sons
- Seitenzahl: 856
- Erscheinungstermin: 21. Juni 2010
- Englisch
- ISBN-13: 9780470622711
- Artikelnr.: 37298053
ASSESSMENT, SCIENCE POLICY, AND REGULATORY FRAMEWORKS. CHAPTER 1 CANCER
RISK ASSESSMENT(Elizabeth L. Anderson, Kimberly Lowe, and Paul Turnham).
References. CHAPTER 2 SCIENCE POLICY AND CANCER RISK ASSESSMENT (Gary E.
Marchant). References. CHAPTER 3 HAZARD AND RISK ASSESSMENT OF CHEMICAL
CARCINOGENICITY WITHIN A REGULATORY CONTEXT (Henk Tennekes, Virginia A.
Gretton, and Todd Stedeford). References. CHAPTER 4 USE OF CANCER RISK
ASSESSMENTS IN DETERMINATION OF REGULATORY STANDARDS (Robert A. Howd and
Anna M. Fan). References. PART II CANCER BIOLOGY AND TOXICOLOGY. CHAPTER 5
THE INTERPLAY OF CANCER AND BIOLOGY (James W. Holder). References. CHAPTER
6 CHEMICAL CARCINOGENESIS: A BRIEF HISTORY OF ITS CONCEPTS WITH A FOCUS ON
POLYCYCLIC AROMATIC HYDROCARBONS (Stephen Nesnow). References. CHAPTER 7
HORMESIS AND CANCER RISKS: ISSUES AND RESOLUTION (Paolo F. Ricci and Edward
J. Calabrese). References. CHAPTER 8 THRESHOLDS FOR GENOTOXIC CARCINOGENS:
EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES (Shoji Fukushima, Min
Wei, Anna Kakehashi, and Hideki Wanibuchi). References. PART III GENETIC
TOXICOLOGY, TESTING GUIDELINES AND REGULATIONS, AND NOVEL ASSAYS. CHAPTER 9
DEVELOPMENT OF GENETIC TOXICOLOGY TESTING AND ITS INCORPORATION INTO
REGULATORY HEALTH EFFECTS TEST REQUIREMENTS (Errol Zeiger). References.
CHAPTER 10 GENETIC TOXICOLOGY TESTING GUIDELINES AND REGULATIONS (Lutz
Müller and Hans-Jörg Martus). References. CHAPTER 11 IN VITRO GENOTOX
ASSAYS (David Kirkland and David Gatehouse). References. CHAPTER 12 IN VIVO
GENOTOXICITY ASSAYS (Véronique Thybaud). References. PART IV ASSESSING THE
HUMAN RELEVANCE OF CHEMICAL-INDUCED TUMORS. CHAPTER 13 FRAMEWORK ANALYSIS
FOR DETERMINING MODE OF ACTION AND HUMAN RELEVANCE (R. Julian Preston).
References. CHAPTER 14 EXPERIMENTAL ANIMAL STUDIES AND CARCINOGENICITY
(Mary Elizabeth (Bette) Meek). References. CHAPTER 15 CANCER EPIDEMIOLOGY
(Herman J. Gibb and Jessie P. Buckley). References. CHAPTER 16 RODENT
HEPATOCARCINOGENESIS (James E. Klaunig). References. CHAPTER 17 MODE OF
ACTION ANALYSIS AND HUMAN RELEVANCE OF LIVER TUMORS INDUCED BY PPARa
ACTIVATION (J. Christopher Corton). References. CHAPTER 18 ALPHA2U-GLOBULIN
NEPHROPATHY AND CHRONIC PROGRESSIVE NEPHROPATHY AS MODES OF ACTION FOR
RENAL TUBULE TUMOR INDUCTION IN RATS, AND THEIR POSSIBLE INTERACTION
(Edward A. Lock and Gordon C. Hard). References. CHAPTER 19 URINARY TRACT
CALCULI AND BLADDER TUMORS (Samuel M. Cohen, Lora L. Arnold, and Shugo
Suzuki). References. PART V METHODS FOR INFORMING CANCER RISK
QUANTIFICATION. CHAPTER 20 (Q)SAR ANALYSIS OF GENOTOXIC AND NONGENOTOXIC
CARCINOGENS: A STATE-OF-THE-ART OVERVIEW (Yin-tak Woo and David Y. Lai).
References. CHAPTER 21 PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS
IN CANCER RISK ASSESSMENT (Mathieu Valcke and Kannan Krishnan). References.
CHAPTER 22 GENOMICS AND ITS ROLE IN CANCER RISK ASSESSMENT (Banalata Sen,
Douglas C. Wolf, and Vicki Dellarco). References. CHAPTER 23 COMPUTATIONAL
TOXICOLOGY IN CANCER RISK ASSESSMENT (Jerry N. Blancato). References. PART
VI GENERAL APPROACHES FOR QUANTIFYING CANCER RISKS. CHAPTER 24 LINEAR
LOW-DOSE EXTRAPOLATIONS (Michael Dourson and Lynne Haber). References.
CHAPTER 25 QUANTITATIVE CANCER RISK ASSESSMENT OF NONGENOTOXIC CARCINOGENS
(Rafael Meza, Jihyoun Jeon, and Suresh H. Moolgavkar). References. CHAPTER
26 NONLINEAR LOW-DOSE EXTRAPOLATIONS (Ari S. Lewis and Barbara D. Beck).
References. CHAPTER 27 CANCER RISK ASSESSMENT: MORE UNCERTAIN THAN WE
THOUGHT (Edmund A. C. Crouch). References. CHAPTER 28 COMBINING NEOPLASMS
FOR EVALUATION OF RODENT CARCINOGENESIS STUDIES (Amy E. Brix, Jerry F.
Hardisty, and Ernest E. McConnell). References. CHAPTER 29 CANCER RISK
BASED ON AN INDIVIDUAL TUMOR TYPE OR SUMMING OF TUMORS (Andrew G. Salmon
and Lindsey A. Roth). References. CHAPTER 30 EXPOSURE RECONSTRUCTION AND
CANCER RISK ESTIMATE DERIVATION (Shannon Gaffney, Jennifer Sahmel, Kathryn
D. Devlin, and Dennis J. Paustenbach). References. INDEX.
ASSESSMENT, SCIENCE POLICY, AND REGULATORY FRAMEWORKS. CHAPTER 1 CANCER
RISK ASSESSMENT(Elizabeth L. Anderson, Kimberly Lowe, and Paul Turnham).
References. CHAPTER 2 SCIENCE POLICY AND CANCER RISK ASSESSMENT (Gary E.
Marchant). References. CHAPTER 3 HAZARD AND RISK ASSESSMENT OF CHEMICAL
CARCINOGENICITY WITHIN A REGULATORY CONTEXT (Henk Tennekes, Virginia A.
Gretton, and Todd Stedeford). References. CHAPTER 4 USE OF CANCER RISK
ASSESSMENTS IN DETERMINATION OF REGULATORY STANDARDS (Robert A. Howd and
Anna M. Fan). References. PART II CANCER BIOLOGY AND TOXICOLOGY. CHAPTER 5
THE INTERPLAY OF CANCER AND BIOLOGY (James W. Holder). References. CHAPTER
6 CHEMICAL CARCINOGENESIS: A BRIEF HISTORY OF ITS CONCEPTS WITH A FOCUS ON
POLYCYCLIC AROMATIC HYDROCARBONS (Stephen Nesnow). References. CHAPTER 7
HORMESIS AND CANCER RISKS: ISSUES AND RESOLUTION (Paolo F. Ricci and Edward
J. Calabrese). References. CHAPTER 8 THRESHOLDS FOR GENOTOXIC CARCINOGENS:
EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES (Shoji Fukushima, Min
Wei, Anna Kakehashi, and Hideki Wanibuchi). References. PART III GENETIC
TOXICOLOGY, TESTING GUIDELINES AND REGULATIONS, AND NOVEL ASSAYS. CHAPTER 9
DEVELOPMENT OF GENETIC TOXICOLOGY TESTING AND ITS INCORPORATION INTO
REGULATORY HEALTH EFFECTS TEST REQUIREMENTS (Errol Zeiger). References.
CHAPTER 10 GENETIC TOXICOLOGY TESTING GUIDELINES AND REGULATIONS (Lutz
Müller and Hans-Jörg Martus). References. CHAPTER 11 IN VITRO GENOTOX
ASSAYS (David Kirkland and David Gatehouse). References. CHAPTER 12 IN VIVO
GENOTOXICITY ASSAYS (Véronique Thybaud). References. PART IV ASSESSING THE
HUMAN RELEVANCE OF CHEMICAL-INDUCED TUMORS. CHAPTER 13 FRAMEWORK ANALYSIS
FOR DETERMINING MODE OF ACTION AND HUMAN RELEVANCE (R. Julian Preston).
References. CHAPTER 14 EXPERIMENTAL ANIMAL STUDIES AND CARCINOGENICITY
(Mary Elizabeth (Bette) Meek). References. CHAPTER 15 CANCER EPIDEMIOLOGY
(Herman J. Gibb and Jessie P. Buckley). References. CHAPTER 16 RODENT
HEPATOCARCINOGENESIS (James E. Klaunig). References. CHAPTER 17 MODE OF
ACTION ANALYSIS AND HUMAN RELEVANCE OF LIVER TUMORS INDUCED BY PPARa
ACTIVATION (J. Christopher Corton). References. CHAPTER 18 ALPHA2U-GLOBULIN
NEPHROPATHY AND CHRONIC PROGRESSIVE NEPHROPATHY AS MODES OF ACTION FOR
RENAL TUBULE TUMOR INDUCTION IN RATS, AND THEIR POSSIBLE INTERACTION
(Edward A. Lock and Gordon C. Hard). References. CHAPTER 19 URINARY TRACT
CALCULI AND BLADDER TUMORS (Samuel M. Cohen, Lora L. Arnold, and Shugo
Suzuki). References. PART V METHODS FOR INFORMING CANCER RISK
QUANTIFICATION. CHAPTER 20 (Q)SAR ANALYSIS OF GENOTOXIC AND NONGENOTOXIC
CARCINOGENS: A STATE-OF-THE-ART OVERVIEW (Yin-tak Woo and David Y. Lai).
References. CHAPTER 21 PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS
IN CANCER RISK ASSESSMENT (Mathieu Valcke and Kannan Krishnan). References.
CHAPTER 22 GENOMICS AND ITS ROLE IN CANCER RISK ASSESSMENT (Banalata Sen,
Douglas C. Wolf, and Vicki Dellarco). References. CHAPTER 23 COMPUTATIONAL
TOXICOLOGY IN CANCER RISK ASSESSMENT (Jerry N. Blancato). References. PART
VI GENERAL APPROACHES FOR QUANTIFYING CANCER RISKS. CHAPTER 24 LINEAR
LOW-DOSE EXTRAPOLATIONS (Michael Dourson and Lynne Haber). References.
CHAPTER 25 QUANTITATIVE CANCER RISK ASSESSMENT OF NONGENOTOXIC CARCINOGENS
(Rafael Meza, Jihyoun Jeon, and Suresh H. Moolgavkar). References. CHAPTER
26 NONLINEAR LOW-DOSE EXTRAPOLATIONS (Ari S. Lewis and Barbara D. Beck).
References. CHAPTER 27 CANCER RISK ASSESSMENT: MORE UNCERTAIN THAN WE
THOUGHT (Edmund A. C. Crouch). References. CHAPTER 28 COMBINING NEOPLASMS
FOR EVALUATION OF RODENT CARCINOGENESIS STUDIES (Amy E. Brix, Jerry F.
Hardisty, and Ernest E. McConnell). References. CHAPTER 29 CANCER RISK
BASED ON AN INDIVIDUAL TUMOR TYPE OR SUMMING OF TUMORS (Andrew G. Salmon
and Lindsey A. Roth). References. CHAPTER 30 EXPOSURE RECONSTRUCTION AND
CANCER RISK ESTIMATE DERIVATION (Shannon Gaffney, Jennifer Sahmel, Kathryn
D. Devlin, and Dennis J. Paustenbach). References. INDEX.