Chronic viral hepatitis is discussed here in a multidisciplinary approach. The editors' goal was to assemble contributions from clinicians, laboratory physicians, epidemiologists, pathologists, and molecular biologists to provide a synopsis of all the important aspects of this disease. A key element in the chronic evolution of viral hepatitis is the persistent coexistence of a cytotoxic immune response and viral gene expression which is discussed in eleven articles on immune pathogenesis. The oncogenicity of hepatitis B virus at the molecular level and of hepatitis C virus at the…mehr
Chronic viral hepatitis is discussed here in a multidisciplinary approach. The editors' goal was to assemble contributions from clinicians, laboratory physicians, epidemiologists, pathologists, and molecular biologists to provide a synopsis of all the important aspects of this disease. A key element in the chronic evolution of viral hepatitis is the persistent coexistence of a cytotoxic immune response and viral gene expression which is discussed in eleven articles on immune pathogenesis. The oncogenicity of hepatitis B virus at the molecular level and of hepatitis C virus at the epidemiological level is discussed in two chapters. The application of PCR for the detection of hepatitis viruses and their variants is a major topic of both practical and theoretical interest. The clinical significance of newly developed serological assays for diagnosis and prevention is discussed in depth by specialists from clinics, transfusion centers and virological laboratories. The therapy of chronic viral hepatitis is still unsatisfactory, but some slow progress is described in several articles. Furthermore, the volume has a special chapter on the often neglected topic of chronic hepatitis in childhood.
Immune pathogenesis of viral hepatitis.- Immune pathogenesis of hepatitis A.- Relapsing hepatitis A in Saimiri monkeys experimentally reinfected with a wild type hepatitis A virus (HAV).- Immune pathogenesis of hepatitis B.- T cell recognition of hepatitis B envelope proteins.- Fine specificity of the human T cell response to hepatitis B virus core antigen.- HBcAg induced T-cell independent anti-HBc production in chronic HBsAg carriers.- Divergent anti-HBc reactivities in HB-immune and chronic HBsAg carriers.- Absence of free core antigen in anti-HBc negative viremic hepatitis B carriers.- Homing of T-lymphocytes in acute and chronic HBV positive inflammatory liver disease.- Hepatitis B virus specific transcripts in peripheral blood mononuclear cells.- Detection of transcriptionally active hepatitis B virus DNA in peripheral mononuclear blood cells after infection during immunosuppressive chemotherapy using the polymerase chain reaction.- Oncogenic properties of hepatitis viruses.- The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors.- Trans-Activation by hepatitis B virus X protein is mediated via a tumour promotor pathway.- Truncated pre-S/S proteins transactivate multiple target sequences.- Hepatitis C virus and hepatocellular carcinoma.- Prevalence of antibodies to hepatitis C virus in patients with hepatocellular carcinoma in Austria.- Hepatitis B virus variants.- Variants of hepatitis B virus.- Hepatitis B virus genomic variations in chronic hepatitis.- Replication of a molecularly cloned HBeAg negative hepatitis B virus variant in transfected HepG2 cells.- Lack of pre-C region mutation in woodchuck hepatitis virus from seroconverted woodchucks.- Clinical significance of polymerase chain reaction (PCR) assay in chronic HBV carriers.- Serodiagnosis of hepatitis B.- PreS antigen expression and anti-preS response in hepatitis B virus infections: relationship to serum HBV-DNA, intrahepatic HBcAg, liver damage and specific T-cell response.- PCR analysis of HBV infected sera: relationship between preS antigens expression and viral replication.- Detection of HBV DNA by PCR in serum from an HBsAg negative blood donor implicated in cases of post-transfusion hepatitis B.- HBc and HBe specificity of monoclonal antibodies against complete and truncated HBc proteins from E. coli.- Measurement of anti-HBc IgM levels using the Amerlite anti-HBc IgM assay.- Evaluation of a new enhanced luminescence immunoassay for confirming the presence of HBsAg in human serum or plasma.- Hepatitis B surface proteins and vaccination.- Functions of hepatitis B surface proteins.- Deletion and insertion mutants of HBsAg particles.- Properties of a recombinant yeast-derived hepatitis B surface antigen containing S, preS2 and preSl antigenic domains.- Diverging policies for vaccination against hepatitis B.- Immunogenicity and safety of a recombinant hepatitis B vaccine produced in mammalian cells and containing the S and the preS2 sequences.- Kinetics of anti-HBs after hepatitis B vaccination: a comparison of two recombinant and one plasma-derived vaccines.- Enhanced luminescent assays for hepatitis markers: Assessment of post vaccine responses.- Characterization of hepatitis C virus.- Comparative molecular biology of flaviviruses and hepatitis C virus.- Hepatitis C viral RNA in serum of patients with chronic non-A, non-B hepatitis: Detection by the polymerase chain reaction using multiple primer sets.- Detection and characterization of hepatitis C virus sequence in the serum of a patient with chronic HCV infection.- Sequence analysis of PCR amplified hepatitis C virus cDNA from French non-A, non-B hepatitis patients.- Antigenicity of synthetic peptides derived from C100 protein of hepatitis C virus.- Localization of hepatitis C virus antigen(s) by immunohistochemistry on fixed-embedded liver tissue.- Identification of HCV-associated antigen(s) in hepatocytes.- Hepatitis C virus
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