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Dr. Jacqueline N. Crawley, author of the First and Second Editionsof What's Wrong with My Mouse? Behavioral Phenotyping ofTransgenic and Knockout Mice,continues to field calls ande-mails from molecular geneticists who ask: how do I runbehavioral assays to find out what's wrong with my mouse? Turn to What's Wrong with My Mouse? to discover thewealth of mouse behavioral tasks and to get the guidance you needto select the best methods and necessary controls. Chapters areorganized by behavioral domain, including measurements of generalhealth, motor functions, sensory abilities, learning and…mehr
Dr. Jacqueline N. Crawley, author of the First and Second Editionsof What's Wrong with My Mouse? Behavioral Phenotyping ofTransgenic and Knockout Mice,continues to field calls ande-mails from molecular geneticists who ask: how do I runbehavioral assays to find out what's wrong with my mouse? Turn to What's Wrong with My Mouse? to discover thewealth of mouse behavioral tasks and to get the guidance you needto select the best methods and necessary controls. Chapters areorganized by behavioral domain, including measurements of generalhealth, motor functions, sensory abilities, learning and memory,feeding and drinking, reproductive, social, emotional, and rewardbehaviors in mutant mice. Throughout the chapters, new behavioraltasks and new research discoveries have been added, bringing theSecond Edition up to date with the latest science. In addition, theSecond Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mousebehavioral tasks relevant to neurodevelopmental diseases, such asmental retardation and autism, and to neurodegenerative diseases,such as Alzheimers, Parkinsons, Huntingtons, and amyotrophiclateral sclerosis. "Putting It All Together" recommends strategies for optimizing abattery of behavioral phenotyping tests to address your specifichypotheses about gene functions. The final chapter, "The Next Generation," examines new andemerging technologies. Throughout the book, the use of behavioral testing equipment isillustrated with photographs, diagrams, and representative data.Examples of behavioral tasks successfully applied to transgenic andknockout mouse models are provided, as well as references to theprimary literature and step-by-step methods protocols. Thesefeatures, along with a comprehensive index, listings of databaseand vendor websites, and an extensive list of references, make thisbook a valuable and practical resource for students andresearchers.
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Jacqueline N. Crawley, PhD, is Chief of the Laboratory ofBehavioral Neuroscience at the National Institute of Mental Health;Adjunct Professor of Psychiatry and Psychology at the University ofNorth Carolina at Chapel Hill; and Adjunct Professor ofPharmacology at Georgetown University. Dr. Crawley has publishedmore than 200 peer-reviewed papers and 60 review articles. Herresearch has included rodent behavioral analyses of noradrenergicpathways; benzodiazepine receptor ligands; neuropeptidetransmitters, including galanin and cholecystokinin; mouse geneticmodels of autism; and behavioral phenotyping of more than 30 linesof transgenic and knockout mice. Recent awards include theInternational Behavioral Neuroscience Society Myers LifetimeAchievement Award (2005), the Fleur Strand Summer NeuropeptideConference Award (2005), the Howard Hughes Medical InstitutePreceptor Award (2004), and the National Institute of Mental HealthDirector's Award (2002). What's Wrong With My Mouse?: Behavioral Phenotyping ofTransgenic and Knockout Mice, Second Edition has been written inDr. Crawley's private capacity, outside of her professionalposition at the National Institutes of Health. The views expressedin this book do not necessarily represent the views of the NationalInstitutes of Health or of the United States government.
Preface to the First Edition.
Chapter 1. Designer Mice.
Chapter 2. Of Unicorns and Chimeras.
Chapter 3. General Health.
Chapter 4. Motor Functions.
Chapter 5. Sensory Abilities.
Chapter 6. Learning and Memory.
Chapter 7. Feeding and Drinking.
Chapter 8. Reproductive Behaviors.
Chapter 9. Social Behaviors.
Chapter 10. Emotional Behaviors: Animal Models of Psychiatric Diseases.
Chapter 11. Reward.
Chapter 12. Neurodevelopment and Neurodegeneration
Chapter 13. Putting It All Together.
Chapter 14. The Next Generation.
First Edition Reviews:
"The book successfully brings together the field of behavioral neuroscience and the rewards and insights that can be gained using this approach. I would recommend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent load to their students, post-doctoral students and colleagues in molecular biology." (Trends in Pharmaceutical Sciences)
"the overall impression is of a helpful guide taking the reader step by step through the complexities of animal behavioral research." (Nature Neuroscience)
"succeeds as a useful introduction to the realm of behavioral phenotyping for those interested in creating or using the large and increasing number of promising targeted mutant mice." (Trends in Neurosciences)
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