-16%
202,99 €
Bisher 241,99 €**
202,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Gebundenes Buch)
Sofort per Download lieferbar
Bisher 241,99 €**
202,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Gebundenes Buch)
Sofort per Download lieferbar

Alle Infos zum eBook verschenken
Als Download kaufen
Bisher 241,99 €**
-16%
202,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Gebundenes Buch)
Sofort per Download lieferbar
Abo Download
9,90 € / Monat*
*Abopreis beinhaltet vier eBooks, die aus der tolino select Titelauswahl im Abo geladen werden können.

inkl. MwSt.
Sofort per Download lieferbar

Einmalig pro Kunde einen Monat kostenlos testen (danach 9,90 € pro Monat), jeden Monat 4 aus 40 Titeln wählen, monatlich kündbar.

Mehr zum tolino select eBook-Abo
Jetzt verschenken
Bisher 241,99 €**
-16%
202,99 €
inkl. MwSt.
**Preis der gedruckten Ausgabe (Gebundenes Buch)
Sofort per Download lieferbar

Alle Infos zum eBook verschenken
0 °P sammeln

  • Format: PDF


Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications critically evaluates thebasic concepts and methodologies of conventional biomarkers as wellas current state-of-the-art assays for measuring antioxidantactivity/oxidative stress and their practical applications. .Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications will be of a greatinterest to scientists who are involved in basic research onoxidation, applied scientists evaluating the effects ofnutraceuticals or pharmaceutical compounds on…mehr

Produktbeschreibung
Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications critically evaluates thebasic concepts and methodologies of conventional biomarkers as wellas current state-of-the-art assays for measuring antioxidantactivity/oxidative stress and their practical applications. .Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications will be of a greatinterest to scientists who are involved in basic research onoxidation, applied scientists evaluating the effects ofnutraceuticals or pharmaceutical compounds on antioxidantactivity/oxidative stress, and physicians who want to understandthe degree of oxidative damage in patients with certain chronicdiseases. Discovering sensitive and specific biomarkers for systemicoxidative damage is essential to understand the role of oxidativestress in human disease. Once these roles are clearly understood,we are able to identify novel drug and nutraceutical targets. Thisvolume goes beyond conventional analytical methods of measuringoverall antioxidant activity and provides insight to the discoveryof biomarkers that reveal information on specific areas ofoxidative stress. Contributed by an international list of experts,Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications describes bothconventional biomarkers and recent developments in this area. Special Features: * Discusses conventional biomarkers as well as recent advancesfor measuring antioxidants and oxidative stress * Biomarkers for lipid peroxidation: isoprostane,hydroxyloctadecaenoic acid, oxysterols, and reactive carbonylspecies from lipid peroxidation * Biomarkers for protein oxidation: carbonylation, tyrosineoxidation, ubiquitin-conjugation * Biomarkers for DNA oxidative damage: comet assay, hydroxylatednucleotides, and exocylcic DNA adducts * Recently developed biomarkers from cutting-edge technology

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, D ausgeliefert werden.

  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 380
  • Erscheinungstermin: 10.08.2010
  • Englisch
  • ISBN-13: 9780813814315
  • Artikelnr.: 37354086
Autorenporträt
Giancarlo Aldini, Ph.D., Department of Pharmaceutical Sciences "Pietro Pratesi", Università degli Studi di Milano, Milan, Italy Kyung-Jin Yeum, Ph.D., Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. Etsuo Niki, Ph.D., , Health Research Institute, National Institute of Advanced Industrial Science & Technology, Osaka, Japan. Robert M. Russell, M.D., Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, MD 20892-7517, USA
Inhaltsangabe
PART I. Biomarkers for Antioxidant Activity. 1. Antioxidant activity and oxidative stress : An Overview. 2. Hydrophilic approach to analyze antioxidant activity. 3. Lipophilic approach to analyze antioxidant activity. 1. LDL Oxidation. PART II. Biomarkers for Oxidative Stress Using Lipid Peroxidation Breakdown. Products & Metabolites. 1. Arachidnoic acid peroxidation products
Isoprostanes. 2. Docosahexaenoic acid peroxidation products
neuroprostanes
and neurofurans. 3. Linoleic acid oxidation products
Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins. 4. Cholesterol oxidation products
oxysterols. 5. GSH dependent metabolism of nucleophilic lipid peroxidation byproducts. PART III. Biomarkers for Oxidative Stress Using Protein carbonyls. 1. Reactive carbonyl species and protein carbonylation: an overview. 2. Immunochemical detection of cabonylated proteins. 3. Mass spectrometric strategies for identification of peptides and proteins modified by reactive carbonyl species. 4. Redox proteomics identification of carbonylated proteins. 5. Ubiquitin conjugates. PART IV. Biomarkers for Oxidative Stress Using DNA damage. 1. Single Cell Gel Electrophoresis
COMET assay. 2. Hydroxyltaed DNA bases. 3. Exocylic DNA adducts. 4. Micro DNA array. PART V. Biomarkers for Oxidative Stress Using Oxidative Modifications of Protein. Thiols. 1.Oxidative modifications of protein thiols and their measurements: an overview. 2. Albumin cys34 oxidation and cytseinliation. 3. Protein S-glutathionilation and S-cysteinilation.
Rezensionen
"Chemists, pharmacologists, and other researchers describe the principles behind current methods for measuring antioxidant activity and oxidative stress and their practical applications in specific health situations." (SciTech Book News, December 2010)