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A unique overview that melds the concepts of conditionalprobability and stochastic processes into real-lifeapplications The role of randomization techniques in clinical trials has becomeincreasingly important. This comprehensive guide combines both theapplied aspects of randomization in clinical trials with aprobabilistic treatment of properties of randomization. Taking anunabashedly non-Bayesian and nonparametric approach to inference,the book focuses on the linear rank test under a randomizationmodel, with added discussion on likelihood-based inference as itrelates to sufficiency and…mehr

Produktbeschreibung
A unique overview that melds the concepts of conditionalprobability and stochastic processes into real-lifeapplications The role of randomization techniques in clinical trials has becomeincreasingly important. This comprehensive guide combines both theapplied aspects of randomization in clinical trials with aprobabilistic treatment of properties of randomization. Taking anunabashedly non-Bayesian and nonparametric approach to inference,the book focuses on the linear rank test under a randomizationmodel, with added discussion on likelihood-based inference as itrelates to sufficiency and ancillarity. Developments in stochasticprocesses and applied probability are also given where appropriate.Intuition is stressed over mathematics, but not without a cleardevelopment of the latter in the context of the former. Providing a consolidated review of the field, the book includesrelevant and practical discussions of: * The benefits of randomization in terms of reduction of bias * Randomization as a basis for inference * Covariate-adaptive and response-adaptive randomization * Current philosophies, controversies, and new developments With ample problem sets, theoretical exercises, and short computersimulations using SAS, Randomization in Clinical Trials: Theory andPractice is equally useful as a standard textbook in biostatisticsgraduate programs as well as a reliable reference forbiostatisticians in practice.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 288
  • Erscheinungstermin: 24. März 2004
  • Englisch
  • ISBN-13: 9780471654070
  • Artikelnr.: 37302082
Autorenporträt
WILLIAM F. ROSENBERGER is an associate professor (with tenure) ofmathematics and statistics at The University of Maryland, BaltimoreCounty. He is also an adjunct associate professor of epidemiologyand preventive medicine at the University of Maryland School ofMedicine. He serves as a biostatistical consultant on severalclinical trials data and safety monitoring boards for the NIH, VA,and industry. He received his PhD in mathematical statistics fromThe George Washington University. JOHN M. LACHIN III is presently Professor of Biostatistics andEpidemiology, and of Statistics, at The George WashingtonUniversity. He holds a ScD in biostatistics from the University ofPittsburgh. He also serves as Director of the Graduate Program inBiostatistics and as Director of the Coordinating Center for twonationwide studies in diabetes.