Schizophrenia

Current Science and Clinical Practice
Herausgegeben von Gaebel, Wolfgang

• Gebundenes Buch

Produktbeschreibung

The first book in a new series from the World Psychiatric Association, Schizophrenia: current science and clinical practice presents recent information on the diagnosis, neurobiological foundations, and management of schizophrenia. It evaluates the findings obtained with modern techniques like magnetic resonance imaging, genetics and network analyses. The book reviews the importance of neurocognitive functioning in schizophrenia and its predictive value for functional capacity. It covers the key areas of early recognition, prevention, rehabilitation and stigma. There is also a critical discussion of diagnostic classification and the revision of the two major international systems.

Written by experts in the field who have a track record of being engaging authors, this book provides a rapid overview of the current state of the art in schizophrenia research and clinical management. It will be invaluable to all psychiatrists, psychologists, neuropharmacologists, researchers in psychiatry and psychopharmacology in academia and in industry, and clinical and behavioural neuroscientists.

Produktdetails

• World Psychiatric Association
• Verlag: Wiley & Sons
• Artikelnr. des Verlages: 14571054000
• 1. Auflage
• Seitenzahl: 272
• Erscheinungstermin: 18. April 2011
• Englisch
• Abmessung: 251mm x 177mm x 22mm
• Gewicht: 620g
• ISBN-13: 9780470710548
• ISBN-10: 0470710543
• Artikelnr.: 32908901

Autorenporträt

Prof. Dr. med. Wolfgang Gaebel is Professor of Psychiatry at the Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. He was Chairman of the German Society for Biological Psychiatry and of the German Society for Psychiatry, Psychotherapy and Neurology. He is a Member of the scientific Advisory Board of the German Medical Association. He is active in various roles within the World Psychiatric Association, including as Chairman of the German Anti-Stigma Association and of the Section on Schizophrenia.

Inhaltsangabe

List of Contributors. Preface. 1 Diagnosis and revision of the
classification systems (Assen Jablensky). Introduction. Origin and
evolution of the concept of schizophrenia. Kraepelin's 'clinical forms'.
Bleuler's 'group of schizophrenias'. Leonhard's 'endogenous psychoses'.
Classification of psychoses in French psychiatry. Other post-Kraepelinian
and post-Bleulerian subtypes and dichotomies. The schizophrenia spectrum
concept. Statistically derived clusters and symptom dimensions.
Schizophrenia in ICD-10 and DSM-IV. Origins of the two classifications.
Both DSM-IV and ICD-10 are descendants of the Kraepelinian nosology.
Criteria for assessing the diagnostic classification of schizophrenia.
Positive impact and unintended adverse effects. Clinical relevance and
cognitive ease of use. Utility in research. Reliability. Concepts of
validity. Predictive validity: course and outcome. Criterion validity:
genetics. Aspects of culture. Reducing stigma. Revision of the
classifications: prospects for schizophrenia. One classification or many?
Critical issues in the revision process. Disease or a broad syndrome?
'Deconstructing' schizophrenia: categories or dimensions? Endophenotypes.
The concept of utility. Conclusion. References. 2 Pathophysiology of
schizophrenia (Peter Falkai, Andrea Schmitt and Tyrone D. Cannon).
Introduction. Major findings and related pathophysiological hypotheses.
Symptom domains and neurotransmitter hypotheses. From domains to disturbed
neuronal networks. From networks to the cellular level. Hypothesis of
disturbed synaptogenesis and neurogenesis. Effects of antipsychotics.
Summary and conclusions. References. 3 Neurocognition, social cognition and
functional outcome in schizophrenia (William P. Horan, Philippe-Olivier
Harvey, Robert S. Kern and Michael F. Green). Introduction. Neurocognition
in schizophrenia. Domains, measurement and magnitude of impairment.
Neurocognition as a core deficit of schizophrenia. Associations with
functional outcome. The NIMH-MATRICS initiative and current research
directions. Social cognition. Domains, measurement and magnitude of
impairment. Social cognition as a core feature of schizophrenia.
Association with functional outcome. Current research directions.
Relationships among neurocognition, social cognition and functional
outcome. Distinctiveness of neurocognition and social cognition. Social
cognition as a mediator. Future directions. References. 4 The genetics of
schizophrenia (James T.R. Walters, Michael O'Donovan and Michael J. Owen).
Introduction. Genetic epidemiology of schizophrenia. Family, twin and
adoption studies of schizophrenia. Genetic epidemiology - informing
diagnosis? Molecular genetics of schizophrenia. Linkage. Positional
candidate studies. Functional candidate studies. Chromosomal abnormalities.
Genome wide association studies. GWAS in schizophrenia. Copy number
variation. The future of schizophrenia genetics. Schizophrenia genetics in
the clinic? Conclusions. Acknowledgements. References. 5 Early recognition
and prevention of schizophrenia (Patrick D. McGorry and Sherilyn
Goldstone). The context for early recognition and prevention. The prodromal
stage: definition and assessment. Treatment during the prodromal stage. The
psychosis risk syndrome: a novel diagnostic entity? Ethical issues. Summary
and conclusions. References. 6 Pharmacological treatment (Jonathan E.
Sherin and Stephen R. Marder). Introduction. Current state of
pharmacological treatment. Phases of schizophrenia. Acute phase treatment.
Stabilization phase treatment. Maintenance phase treatment. Treatment
resistant patients. Managing first episodes. Newer antipsychotics.
Personalising drug treatment in schizophrenia. Cognition and negative
symptoms as therapeutic targets. Glutamatergic targets. Dopamine targets.
Cholinergic targets. Histamine targets. Summary. References. 7
Cognitive-behavioural interventions (Suzanne Jolley and Philippa Garety).
Introduction. The development of cognitive behavioural approaches to
schizophrenia-spectrum psychosis. Cognitive behavioural models of
psychosis. Biopsychosocial vulnerability. Life events and schematic
beliefs. The role of affect. The central role of appraisal. Reasoning
biases. Anomalous experiences. The role of behaviour. Insight and illness
appraisals. Cognitive behavioural therapy in schizophrenia. Psychotherapy
in schizophrenia: more than unspecific learning? Combining psychotherapy
and pharmacotherapy. Efficacy of cognitive behavioural therapy for
psychosis (CBTp). Future developments. Conclusions. Acknowledgements.
References. 8 Management, rehabilitation, stigma (Wulf Rossler).
Introduction. Managing schizophrenia: integrative approaches. Burden for
patients, families and communities. Gender issues. Mortality. Legal
problems. Health care settings for schizophrenia patients: which setting is
optimal? Psychiatric rehabilitation. The international classification of
functioning, disability and health. Target population. Conceptual
framework. Current approaches. Individual-centred rehabilitation. Cognitive
behavioural therapy. Social skills training. Ecological approach to
rehabilitation. Housing. Work. Participation in community life with full
rights. The contribution of mental health professionals to stigma and
discrimination. The role of the psychiatrist in the management and
rehabilitation of schizophrenia patients. Outlook. References. Index.